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- W4313359526 abstract "Abstract Influenza’s propensity for antigenic drift and shift, and to elicit predominantly strain specific antibodies (Abs) leaves humanity susceptible to waves of new strains with pandemic potential for which limited or no immunity may exist. Subsequently new clinical interventions are needed, particularly those with broad activity against diverse strains. Although hemagglutinin (HA) specificity dominates the humoral response to seasonal inactivated influenza vaccines and infection, Abs targeting neuraminidase (NA) are also generated. NA-specific Abs are suggested to act primarily through inhibiting its enzymatic activity and preventing release of virus from infected cells. Relative to HA, there is substantially less diversity among NA from different influenza types and subtypes, suggesting it is a valuable target for inducing broad protective immunity. To determine if humans generate NA-specific Abs with protective activity we examined plasmablasts from subjects that were immunized with the seasonal influenza inactivated vaccine, and isolated several NA-specific human monoclonal Abs (hmAbs), including those with potent in vitro viral neutralizing activity. One of the NA B–specific hmAbs, KPF2 recognized NA from both the Yamagata and Victoria lineages, and when administered prophylactically to mice resulted in sterilizing immunity. These results suggest seasonal influenza vaccine induces protective NA-specific mAbs in humans. Analysis of other NA-specific hmAbs is ongoing." @default.
- W4313359526 created "2023-01-06" @default.
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- W4313359526 date "2018-05-01" @default.
- W4313359526 modified "2023-10-12" @default.
- W4313359526 title "Induction and isolation of protective influenza neuraminidase specific antibodies in humans following seasonal vaccination." @default.
- W4313359526 doi "https://doi.org/10.4049/jimmunol.200.supp.60.17" @default.
- W4313359526 hasPublicationYear "2018" @default.
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