Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313359532> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W4313359532 endingPage "60.8" @default.
- W4313359532 startingPage "60.8" @default.
- W4313359532 abstract "Abstract Human metapneumovirus (HMPV) is a negative sense, single stranded RNA virus that belongs to the Pneumovirdae family, and represents an important pathogen that causes severe bronchiolitis and pneumonia worldwide. There is currently no vaccine against this virus, so it is important to study the aspects of the immune response induced by HMPV in order to understand its mechanism of infection. Because infiltration of mucus is a hallmark of HMPV infection, it is warranted to study the role of mucus in the disease process. Mucin proteins make up the major component of mucus and can be found within the airway and lungs. Using an in vitro model of HMPV infection and human bronchial epithelial cells, we found that HMPV induced predominantly a mucin 19 expression. Those data were confirmed in mice, where HMPV induced predominant levels of muc19 protein. Mucin 19 is a secreted gel-forming mucin, whose function is largely understudied, particularly in the respiratory tract. Our findings led us to hypothesize that mucin 19 plays a role in HMPV infection. To test that, we used a muc19 knockout mouse model. Lung samples were collected at different time points. Sample analysis showed that the absence of muc19 led to an increased pulmonary inflammation and body weight loss. Interestingly, flow cytometry data indicate that the lack of Muc19 resulted in a decreased CD4+ T cell count in the lung, and reduced numbers of CD4+ and CD8+ T cells in the lymph nodes after HMPV infection. These novel findings yield relevant information regarding the contribution of the mucins, specifically Muc19, on the immune response induced by respiratory viral infections in the lung." @default.
- W4313359532 created "2023-01-06" @default.
- W4313359532 creator A5051870329 @default.
- W4313359532 creator A5062507415 @default.
- W4313359532 creator A5081062983 @default.
- W4313359532 date "2018-05-01" @default.
- W4313359532 modified "2023-09-28" @default.
- W4313359532 title "Role of mucin 19 in the respiratory tract." @default.
- W4313359532 doi "https://doi.org/10.4049/jimmunol.200.supp.60.8" @default.
- W4313359532 hasPublicationYear "2018" @default.
- W4313359532 type Work @default.
- W4313359532 citedByCount "1" @default.
- W4313359532 countsByYear W43133595322022 @default.
- W4313359532 crossrefType "journal-article" @default.
- W4313359532 hasAuthorship W4313359532A5051870329 @default.
- W4313359532 hasAuthorship W4313359532A5062507415 @default.
- W4313359532 hasAuthorship W4313359532A5081062983 @default.
- W4313359532 hasBestOaLocation W43133595322 @default.
- W4313359532 hasConcept C105702510 @default.
- W4313359532 hasConcept C126322002 @default.
- W4313359532 hasConcept C159047783 @default.
- W4313359532 hasConcept C179264091 @default.
- W4313359532 hasConcept C18903297 @default.
- W4313359532 hasConcept C203014093 @default.
- W4313359532 hasConcept C2522874641 @default.
- W4313359532 hasConcept C2776012195 @default.
- W4313359532 hasConcept C2776460866 @default.
- W4313359532 hasConcept C2777312293 @default.
- W4313359532 hasConcept C2777714996 @default.
- W4313359532 hasConcept C2777914695 @default.
- W4313359532 hasConcept C2778821649 @default.
- W4313359532 hasConcept C2779644171 @default.
- W4313359532 hasConcept C2780475896 @default.
- W4313359532 hasConcept C534529494 @default.
- W4313359532 hasConcept C553184892 @default.
- W4313359532 hasConcept C55493867 @default.
- W4313359532 hasConcept C71924100 @default.
- W4313359532 hasConcept C86803240 @default.
- W4313359532 hasConcept C8891405 @default.
- W4313359532 hasConceptScore W4313359532C105702510 @default.
- W4313359532 hasConceptScore W4313359532C126322002 @default.
- W4313359532 hasConceptScore W4313359532C159047783 @default.
- W4313359532 hasConceptScore W4313359532C179264091 @default.
- W4313359532 hasConceptScore W4313359532C18903297 @default.
- W4313359532 hasConceptScore W4313359532C203014093 @default.
- W4313359532 hasConceptScore W4313359532C2522874641 @default.
- W4313359532 hasConceptScore W4313359532C2776012195 @default.
- W4313359532 hasConceptScore W4313359532C2776460866 @default.
- W4313359532 hasConceptScore W4313359532C2777312293 @default.
- W4313359532 hasConceptScore W4313359532C2777714996 @default.
- W4313359532 hasConceptScore W4313359532C2777914695 @default.
- W4313359532 hasConceptScore W4313359532C2778821649 @default.
- W4313359532 hasConceptScore W4313359532C2779644171 @default.
- W4313359532 hasConceptScore W4313359532C2780475896 @default.
- W4313359532 hasConceptScore W4313359532C534529494 @default.
- W4313359532 hasConceptScore W4313359532C553184892 @default.
- W4313359532 hasConceptScore W4313359532C55493867 @default.
- W4313359532 hasConceptScore W4313359532C71924100 @default.
- W4313359532 hasConceptScore W4313359532C86803240 @default.
- W4313359532 hasConceptScore W4313359532C8891405 @default.
- W4313359532 hasIssue "1_Supplement" @default.
- W4313359532 hasLocation W43133595321 @default.
- W4313359532 hasLocation W43133595322 @default.
- W4313359532 hasOpenAccess W4313359532 @default.
- W4313359532 hasPrimaryLocation W43133595321 @default.
- W4313359532 hasRelatedWork W2045605122 @default.
- W4313359532 hasRelatedWork W2065641364 @default.
- W4313359532 hasRelatedWork W2348392246 @default.
- W4313359532 hasRelatedWork W2373271253 @default.
- W4313359532 hasRelatedWork W2400491472 @default.
- W4313359532 hasRelatedWork W2418530387 @default.
- W4313359532 hasRelatedWork W2515080202 @default.
- W4313359532 hasRelatedWork W2619100308 @default.
- W4313359532 hasRelatedWork W4281710224 @default.
- W4313359532 hasRelatedWork W91214295 @default.
- W4313359532 hasVolume "200" @default.
- W4313359532 isParatext "false" @default.
- W4313359532 isRetracted "false" @default.
- W4313359532 workType "article" @default.