Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313359560> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W4313359560 endingPage "44.24" @default.
- W4313359560 startingPage "44.24" @default.
- W4313359560 abstract "Abstract Asthma impacts over 24 million people and costs about $56 billion annually in the United States. Airway neutrophil accumulation and high levels of IL-17 are characteristic of severe asthma. However, mechanisms underlying IL-17/neutrophilic inflammation in severe asthma remain poorly defined. Scavenger receptor class B type I (SR-BI) is a multi-recognition receptor that regulates cholesterol trafficking. We previously reported SR-BI dampens pulmonary innate immune responses during bacterial pneumonia, but the role of SR-BI in asthma is unknown. We hypothesize pulmonary SR-BI expression is protective against house dust mite (HDM)-induced IL-17-dependent neutrophilic asthma. SR-BI+/+ and SR-BI−/− mice were sensitized with 10 μg HDM by oropharyngeal aspiration on day 0 and 7, and challenged with 2 μg HDM on day 14, 15, 16. Airway inflammation and cytokine production were quantified on day 17. SR-BI−/− mice had increased neutrophils but decreased eosinophils in bronchoalveolar lavage (BAL) after HDM challenge compared to SR-BI+/+ mice. BAL levels of neutrophil chemoattractants CXCL1, CXCL2 and CXCL5 were not significantly different between SR-BI+/+ and SR-BI−/− mice. SR-BI−/− mice had increased pulmonary IL-17A and GM-CSF production and decreased IL-5 production. To identify cellular sources of airspace IL-17, single cells isolated from lung were labeled with antibodies for flow cytometry. IL-17A increased in neutrophils (CD45+Ly6G+) and macrophages (CD45+CD64+CD11b−CD11c+) but not T cells (CD45+CD4+) of asthmatic SR-BI−/− mice suggesting myeloid cells rather than Th17 cells as sources of IL-17. Overall, SR-BI expression in the lung suppresses neutrophilic inflammation and IL-17 production in HDM-induced asthma model." @default.
- W4313359560 created "2023-01-06" @default.
- W4313359560 creator A5006672267 @default.
- W4313359560 creator A5024276896 @default.
- W4313359560 creator A5039614579 @default.
- W4313359560 creator A5041209504 @default.
- W4313359560 creator A5047235136 @default.
- W4313359560 creator A5047545861 @default.
- W4313359560 creator A5047668620 @default.
- W4313359560 creator A5055586787 @default.
- W4313359560 creator A5075455244 @default.
- W4313359560 date "2018-05-01" @default.
- W4313359560 modified "2023-09-27" @default.
- W4313359560 title "Scavenger receptor BI attenuates IL-17-dependent neutrophilic inflammation in asthma." @default.
- W4313359560 doi "https://doi.org/10.4049/jimmunol.200.supp.44.24" @default.
- W4313359560 hasPublicationYear "2018" @default.
- W4313359560 type Work @default.
- W4313359560 citedByCount "0" @default.
- W4313359560 crossrefType "journal-article" @default.
- W4313359560 hasAuthorship W4313359560A5006672267 @default.
- W4313359560 hasAuthorship W4313359560A5024276896 @default.
- W4313359560 hasAuthorship W4313359560A5039614579 @default.
- W4313359560 hasAuthorship W4313359560A5041209504 @default.
- W4313359560 hasAuthorship W4313359560A5047235136 @default.
- W4313359560 hasAuthorship W4313359560A5047545861 @default.
- W4313359560 hasAuthorship W4313359560A5047668620 @default.
- W4313359560 hasAuthorship W4313359560A5055586787 @default.
- W4313359560 hasAuthorship W4313359560A5075455244 @default.
- W4313359560 hasConcept C104317684 @default.
- W4313359560 hasConcept C126322002 @default.
- W4313359560 hasConcept C127716648 @default.
- W4313359560 hasConcept C12823836 @default.
- W4313359560 hasConcept C13373296 @default.
- W4313359560 hasConcept C179661763 @default.
- W4313359560 hasConcept C203014093 @default.
- W4313359560 hasConcept C2776914184 @default.
- W4313359560 hasConcept C2777714996 @default.
- W4313359560 hasConcept C2777802486 @default.
- W4313359560 hasConcept C2777961210 @default.
- W4313359560 hasConcept C2778163477 @default.
- W4313359560 hasConcept C2779919695 @default.
- W4313359560 hasConcept C2780072125 @default.
- W4313359560 hasConcept C41443022 @default.
- W4313359560 hasConcept C55493867 @default.
- W4313359560 hasConcept C71924100 @default.
- W4313359560 hasConcept C86803240 @default.
- W4313359560 hasConcept C96525457 @default.
- W4313359560 hasConceptScore W4313359560C104317684 @default.
- W4313359560 hasConceptScore W4313359560C126322002 @default.
- W4313359560 hasConceptScore W4313359560C127716648 @default.
- W4313359560 hasConceptScore W4313359560C12823836 @default.
- W4313359560 hasConceptScore W4313359560C13373296 @default.
- W4313359560 hasConceptScore W4313359560C179661763 @default.
- W4313359560 hasConceptScore W4313359560C203014093 @default.
- W4313359560 hasConceptScore W4313359560C2776914184 @default.
- W4313359560 hasConceptScore W4313359560C2777714996 @default.
- W4313359560 hasConceptScore W4313359560C2777802486 @default.
- W4313359560 hasConceptScore W4313359560C2777961210 @default.
- W4313359560 hasConceptScore W4313359560C2778163477 @default.
- W4313359560 hasConceptScore W4313359560C2779919695 @default.
- W4313359560 hasConceptScore W4313359560C2780072125 @default.
- W4313359560 hasConceptScore W4313359560C41443022 @default.
- W4313359560 hasConceptScore W4313359560C55493867 @default.
- W4313359560 hasConceptScore W4313359560C71924100 @default.
- W4313359560 hasConceptScore W4313359560C86803240 @default.
- W4313359560 hasConceptScore W4313359560C96525457 @default.
- W4313359560 hasIssue "1_Supplement" @default.
- W4313359560 hasLocation W43133595601 @default.
- W4313359560 hasOpenAccess W4313359560 @default.
- W4313359560 hasPrimaryLocation W43133595601 @default.
- W4313359560 hasRelatedWork W2015332575 @default.
- W4313359560 hasRelatedWork W2087401044 @default.
- W4313359560 hasRelatedWork W2117759677 @default.
- W4313359560 hasRelatedWork W2167083761 @default.
- W4313359560 hasRelatedWork W2907471984 @default.
- W4313359560 hasRelatedWork W3035440422 @default.
- W4313359560 hasRelatedWork W3047489422 @default.
- W4313359560 hasRelatedWork W4292865376 @default.
- W4313359560 hasRelatedWork W4312223455 @default.
- W4313359560 hasRelatedWork W4313359560 @default.
- W4313359560 hasVolume "200" @default.
- W4313359560 isParatext "false" @default.
- W4313359560 isRetracted "false" @default.
- W4313359560 workType "article" @default.