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- W4313359617 abstract "Abstract Cytosolic RNA receptors, RLRs, play an essential role in antiviral infections that specifically detect the invaded viral RNAs leading to IFN and ISG expression and antiviral reactions through RNA sensing signaling pathways. This viral RNA sensing mechanism tolerate cellular “self” RNA in normal cells. However, how RLRs distinguish viral and self RNA molecules remains ambiguous. Our recent study showed that insufficient RNA editing by editing enzyme ADAR1 enables the cellular endogenous RNAs to stimulate the RLRs and activate the innate immune signaling pathway that lead to type I IFN and ISGs expression. Specific deletion of ADAR1 in the hepatocytes in a mouse model causes profound inflammation in the liver. As a result, the mortality rate is dramatically increased in the young animals. However, deletion of MDA-5 in these ADAR1 KO mice completely rescues the mice, and all the inflammatory phenotype was reversed. This finding indicated that RNA editing is necessary for the innate immune homeostasis, and MDA-5 plays a critical role in sensing endogenous self RNAs. Studies on this endogenous RNA sensing signaling pathway, its regulation and potential involvement in autoimmune and inflammatory diseases is warranted." @default.
- W4313359617 created "2023-01-06" @default.
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- W4313359617 date "2018-05-01" @default.
- W4313359617 modified "2023-10-16" @default.
- W4313359617 title "RNA editing is required for innate immune homeostasis through inhibiting cytosolic RNA receptor MDA-5 activated by cellular endogenous RNAs" @default.
- W4313359617 doi "https://doi.org/10.4049/jimmunol.200.supp.169.3" @default.
- W4313359617 hasPublicationYear "2018" @default.
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