Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313359635> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4313359635 endingPage "118.2" @default.
- W4313359635 startingPage "118.2" @default.
- W4313359635 abstract "Abstract Mucosa-associated lymphoid tissues contain roughly 80% of all immune cells and produce virtually all of the body’s IgA. Although the majority of IgA-secreting cells educated within a mucosal site home back to the same anatomic region, some cells are also found in distant mucosal tissues. These observations underlie the notion of a common mucosal immune system, which holds that anatomically unrelated mucosal sites are functionally connected by a shared immune system. However, the ontological basis of this separation between site of immune education and functionality has remained elusive. Here we show that mice lacking Peyer’s patches (PPs)—small-intestinal lymphoid tissue covered by antigen-sampling M cells—have no immunologic defect in the small-intestinal lamina propria. Surprisingly, the primary immunological abnormality in PP-deficient mice was a reduction in colonic B cells, including plasmablasts but not plasma cells. Adoptive transfer experiments conclusively demonstrated that PP-derived cells preferentially give rise to colonic—but not small-intestinal—B cells and plasmablasts. Finally, these PP-derived colonic B cells were critical for restraining colonic inflammation. Thus, PPs bridge the small-intestinal and colonic immune systems and provide a clear example of immune education being required in an anatomic compartment distinct from the effector site. Our findings, which highlight that the majority of fecal IgA is produced by colonic plasmablasts that originate from PPs, will help inform design of mucosal vaccines." @default.
- W4313359635 created "2023-01-06" @default.
- W4313359635 creator A5008137729 @default.
- W4313359635 creator A5013370492 @default.
- W4313359635 date "2018-05-01" @default.
- W4313359635 modified "2023-09-27" @default.
- W4313359635 title "Anatomically remote education of B cells is required for colonic health" @default.
- W4313359635 doi "https://doi.org/10.4049/jimmunol.200.supp.118.2" @default.
- W4313359635 hasPublicationYear "2018" @default.
- W4313359635 type Work @default.
- W4313359635 citedByCount "0" @default.
- W4313359635 crossrefType "journal-article" @default.
- W4313359635 hasAuthorship W4313359635A5008137729 @default.
- W4313359635 hasAuthorship W4313359635A5013370492 @default.
- W4313359635 hasBestOaLocation W43133596352 @default.
- W4313359635 hasConcept C111368507 @default.
- W4313359635 hasConcept C127313418 @default.
- W4313359635 hasConcept C147483822 @default.
- W4313359635 hasConcept C181152851 @default.
- W4313359635 hasConcept C203014093 @default.
- W4313359635 hasConcept C203635412 @default.
- W4313359635 hasConcept C2776090121 @default.
- W4313359635 hasConcept C2776914184 @default.
- W4313359635 hasConcept C2777310793 @default.
- W4313359635 hasConcept C43667030 @default.
- W4313359635 hasConcept C529295009 @default.
- W4313359635 hasConcept C54355233 @default.
- W4313359635 hasConcept C86803240 @default.
- W4313359635 hasConcept C8891405 @default.
- W4313359635 hasConcept C90375314 @default.
- W4313359635 hasConceptScore W4313359635C111368507 @default.
- W4313359635 hasConceptScore W4313359635C127313418 @default.
- W4313359635 hasConceptScore W4313359635C147483822 @default.
- W4313359635 hasConceptScore W4313359635C181152851 @default.
- W4313359635 hasConceptScore W4313359635C203014093 @default.
- W4313359635 hasConceptScore W4313359635C203635412 @default.
- W4313359635 hasConceptScore W4313359635C2776090121 @default.
- W4313359635 hasConceptScore W4313359635C2776914184 @default.
- W4313359635 hasConceptScore W4313359635C2777310793 @default.
- W4313359635 hasConceptScore W4313359635C43667030 @default.
- W4313359635 hasConceptScore W4313359635C529295009 @default.
- W4313359635 hasConceptScore W4313359635C54355233 @default.
- W4313359635 hasConceptScore W4313359635C86803240 @default.
- W4313359635 hasConceptScore W4313359635C8891405 @default.
- W4313359635 hasConceptScore W4313359635C90375314 @default.
- W4313359635 hasIssue "1_Supplement" @default.
- W4313359635 hasLocation W43133596351 @default.
- W4313359635 hasLocation W43133596352 @default.
- W4313359635 hasOpenAccess W4313359635 @default.
- W4313359635 hasPrimaryLocation W43133596351 @default.
- W4313359635 hasRelatedWork W1557621914 @default.
- W4313359635 hasRelatedWork W1978730674 @default.
- W4313359635 hasRelatedWork W2036001773 @default.
- W4313359635 hasRelatedWork W2091358697 @default.
- W4313359635 hasRelatedWork W2163938746 @default.
- W4313359635 hasRelatedWork W2220102944 @default.
- W4313359635 hasRelatedWork W27204544 @default.
- W4313359635 hasRelatedWork W2895048412 @default.
- W4313359635 hasRelatedWork W2980981525 @default.
- W4313359635 hasRelatedWork W4313359635 @default.
- W4313359635 hasVolume "200" @default.
- W4313359635 isParatext "false" @default.
- W4313359635 isRetracted "false" @default.
- W4313359635 workType "article" @default.