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- W4313359722 abstract "Abstract Interleukin-27 receptor alpha (IL-27Rα) is a co-receptor of IL-27, which is an inflammatory cytokine and displays extensive immunological functions. It has been reported that IL-27Rα can exist in its soluble form (sIL-27Rα) in human serum and function as a natural IL-27 antagonist. In this study, we examined the serum sIL-27Rα levels and evaluated its predictive and prognosis value in aGVHD. Serum sIL-27Rα levels at the time of neutrophil engraftment were significantly decreased in grade II–IV aGVHD patients (P<0.001) as well as in patients with skin (P<0.01) or liver aGVHD (P<0.05). sIL-27Rα at neutrophil engraftment could be used to predict grade II–IV aGVHD (AUC=0.735, 95% CI 0.618–0.853, P=0.001). Cumulative incidences of grade II–IV aGVHD (P=0.004), recurrence rate (P=0.008), and non-recurrent mortality (P=0.008) in patients with high serum sIL-27Rα (≥59.40 ng/ml) were significantly lower than those in patients with low serum sIL-27Rα (<59.40 ng/ml). Multivariate analysis confirmed that low sIL-27Rα level at neutrophil engraftment (HR=2.83 95%CI 1.29–6.19, P<0.01) was an independent risk factor for predicting grade II–IV aGVHD. In addition, serum sIL-27Rα were positively associated with IL-27 (R=0.27, P=0.029), IL-10 (R=0.37, P=0.0015) and HGF (R=0.27, P=0.0208), whereas negatively associated with TNFR1 (R=−0.365, P=0.0022), Elafin (R=−0.29, P=0.0117), and REG3α (R=−0.417, P=0.0003). Taken together, our findings demonstrated that serum sIL-27Rα was upregulated after allo-HSCT, their levels at neutrophil engraftment maybe a valuable predictive biomarker in predicting the incidence of moderate-to-severe aGVHD after allo-HSCT." @default.
- W4313359722 created "2023-01-06" @default.
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- W4313359722 date "2018-05-01" @default.
- W4313359722 modified "2023-09-27" @default.
- W4313359722 title "Soluble interleukin-27 receptor alpha is a valuable predictive biomarker for acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation" @default.
- W4313359722 doi "https://doi.org/10.4049/jimmunol.200.supp.55.18" @default.
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