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- W4313359801 abstract "Abstract Diarrheagenic Escherichia coli remain a significant health challenge, particularly in developing countries. Challenges in the use of small animal models for enteric infections highlight the need for development of alternative model systems. The social amoeba, Dictyostelium discoideum, which phagocytizes bacteria for nutritional purposes, serves as a host model for several pathogenic bacteria, including E. coli. Previous studies characterized interactions of D. discoideum with commensal and extraintestinal E. coli. In the current study, we extend this characterization to analyze the grazing interactions of D. discoideum with 35 representative diarrheagenic, extraintestinal and commensal E. coli strains. We found that E. coli strains sensitive and resistant to D. discoideum grazing are present in each pathotype. Whole genome phylogenomic analysis revealed that grazing resistance to D. discoideum is distributed among the phylotypes, although resistant strains are enriched in the B2 phylogenomic group. Comparative genomic analysis identified genes that were more prevalent among strains resistant to D. discoideum grazing. While not providing direct insight into conserved mechanisms of resistance, these identified genes do provide avenues for further investigation. Phenotypic analysis revealed that E. coli strains resistant to D. discoideum grazing also exhibited increased resistance to the reducing agent, β-ME. These data extend the characterization of interactions between D. discoideum and E. coli, and through comparative genomics identify candidate E. coli genes that may be associated with resistance to grazing by the model phagocyte D. discoideum, and by extension with resistance to phagocytic immune cells." @default.
- W4313359801 created "2023-01-06" @default.
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- W4313359801 date "2018-05-01" @default.
- W4313359801 modified "2023-10-16" @default.
- W4313359801 title "Comparative genomic analysis of <i>Escherichia coli</i> strains resistant to grazing by the social amoeba <i>Dictyostelium discoideum</i>" @default.
- W4313359801 doi "https://doi.org/10.4049/jimmunol.200.supp.117.23" @default.
- W4313359801 hasPublicationYear "2018" @default.
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