Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313359809> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W4313359809 endingPage "182.18" @default.
- W4313359809 startingPage "182.18" @default.
- W4313359809 abstract "Abstract Vitamin A is an essential nutritional constituent that governs a broad spectrum of cell biology through the activation of its nuclear receptor complexes. The active metabolite of vitamin A, all-trans retinoic acid (ATRA), binds to the chaperone molecule, cytoplasmic retinoic acid binding protein (CRABP) 1 or 2 to regulate its signaling pathways. Given the extremely high homology, CRABP1 and 2 have been predicted to play a redundant role. However, a few studies by others suggested that CRABP1 and 2 might differentially regulate the cellular response to ATRA. Although the antiviral effect of ATRA is well recognized, the roles of CRABPs in the regulation of viral pathogens have never been studied. In this study, we employed hepatitis C virus (HCV) as a study model to assess the importance of CRABPs. Of great interest, CRABP1 expression enhanced HCV infection while CRABP2 expression resulted in the suppression of HCV lifecycle. Our follow up studies collectively indicated that CRABPs regulate the efficiency of HCV infection through the modulation of lipid droplet (LD) abundance wherein HCV establishes the replicase complex. The transcriptome analysis revealed that CRABP1 expression downregulated the genes regulated by ATRA and is associated with the expression of genes involved in the steatosis of the liver. In contrast, CRABP2 expression augmented ATRA response, resulting in the inhibition of LD accumulation. Moreover, the chemical inhibition of the CRABP1 and 2 pathways resulted in the abrogation of their pro- and antiviral effect, respectively. In conclusion, our study revealed a novel link between the cellular response to the micronutrients and its influence on the viral infectious disease." @default.
- W4313359809 created "2023-01-06" @default.
- W4313359809 creator A5041495820 @default.
- W4313359809 creator A5063037219 @default.
- W4313359809 creator A5065387885 @default.
- W4313359809 creator A5070288633 @default.
- W4313359809 creator A5072887923 @default.
- W4313359809 creator A5087592842 @default.
- W4313359809 creator A5090536973 @default.
- W4313359809 creator A5091172311 @default.
- W4313359809 date "2018-05-01" @default.
- W4313359809 modified "2023-09-26" @default.
- W4313359809 title "CRABP1 and 2 differentially regulate HCV infection via modulation of lipid droplet abundance." @default.
- W4313359809 doi "https://doi.org/10.4049/jimmunol.200.supp.182.18" @default.
- W4313359809 hasPublicationYear "2018" @default.
- W4313359809 type Work @default.
- W4313359809 citedByCount "0" @default.
- W4313359809 crossrefType "journal-article" @default.
- W4313359809 hasAuthorship W4313359809A5041495820 @default.
- W4313359809 hasAuthorship W4313359809A5063037219 @default.
- W4313359809 hasAuthorship W4313359809A5065387885 @default.
- W4313359809 hasAuthorship W4313359809A5070288633 @default.
- W4313359809 hasAuthorship W4313359809A5072887923 @default.
- W4313359809 hasAuthorship W4313359809A5087592842 @default.
- W4313359809 hasAuthorship W4313359809A5090536973 @default.
- W4313359809 hasAuthorship W4313359809A5091172311 @default.
- W4313359809 hasConcept C104317684 @default.
- W4313359809 hasConcept C150194340 @default.
- W4313359809 hasConcept C159047783 @default.
- W4313359809 hasConcept C162317418 @default.
- W4313359809 hasConcept C170493617 @default.
- W4313359809 hasConcept C173396325 @default.
- W4313359809 hasConcept C179639408 @default.
- W4313359809 hasConcept C190283241 @default.
- W4313359809 hasConcept C2522874641 @default.
- W4313359809 hasConcept C2776408679 @default.
- W4313359809 hasConcept C2781121885 @default.
- W4313359809 hasConcept C502942594 @default.
- W4313359809 hasConcept C54355233 @default.
- W4313359809 hasConcept C62478195 @default.
- W4313359809 hasConcept C63932345 @default.
- W4313359809 hasConcept C86339819 @default.
- W4313359809 hasConcept C86803240 @default.
- W4313359809 hasConcept C95444343 @default.
- W4313359809 hasConceptScore W4313359809C104317684 @default.
- W4313359809 hasConceptScore W4313359809C150194340 @default.
- W4313359809 hasConceptScore W4313359809C159047783 @default.
- W4313359809 hasConceptScore W4313359809C162317418 @default.
- W4313359809 hasConceptScore W4313359809C170493617 @default.
- W4313359809 hasConceptScore W4313359809C173396325 @default.
- W4313359809 hasConceptScore W4313359809C179639408 @default.
- W4313359809 hasConceptScore W4313359809C190283241 @default.
- W4313359809 hasConceptScore W4313359809C2522874641 @default.
- W4313359809 hasConceptScore W4313359809C2776408679 @default.
- W4313359809 hasConceptScore W4313359809C2781121885 @default.
- W4313359809 hasConceptScore W4313359809C502942594 @default.
- W4313359809 hasConceptScore W4313359809C54355233 @default.
- W4313359809 hasConceptScore W4313359809C62478195 @default.
- W4313359809 hasConceptScore W4313359809C63932345 @default.
- W4313359809 hasConceptScore W4313359809C86339819 @default.
- W4313359809 hasConceptScore W4313359809C86803240 @default.
- W4313359809 hasConceptScore W4313359809C95444343 @default.
- W4313359809 hasIssue "1_Supplement" @default.
- W4313359809 hasLocation W43133598091 @default.
- W4313359809 hasOpenAccess W4313359809 @default.
- W4313359809 hasPrimaryLocation W43133598091 @default.
- W4313359809 hasRelatedWork W1973087247 @default.
- W4313359809 hasRelatedWork W2000763329 @default.
- W4313359809 hasRelatedWork W2128064186 @default.
- W4313359809 hasRelatedWork W2185875796 @default.
- W4313359809 hasRelatedWork W2404112627 @default.
- W4313359809 hasRelatedWork W2411657021 @default.
- W4313359809 hasRelatedWork W2564412933 @default.
- W4313359809 hasRelatedWork W2605325727 @default.
- W4313359809 hasRelatedWork W2704607352 @default.
- W4313359809 hasRelatedWork W4296794035 @default.
- W4313359809 hasVolume "200" @default.
- W4313359809 isParatext "false" @default.
- W4313359809 isRetracted "false" @default.
- W4313359809 workType "article" @default.