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- W4313359949 abstract "Abstract TACI (transmembrane activator and calcium-modulator and cyclophilin ligand interactor) is one of receptors for the TNF superfamily cytokines BAFF (B cell activating factor) and APRIL (A Proliferation Inducing Ligand). In this study, we investigated the role of TACI in high fat diet induced obesity and metabolic disease. Compared to WT mice, TACI KO mice exhibited less weight gain, decreased body fat, enhanced glucose tolerance and insulin sensitivity. Improved metabolic changes in TACI KO mice were accompanied by significantly less accumulation of CD8+ T cells and F4/80+CD11c+ inflammatory macrophages in visceral fat pad. In addition, TACI KO mouse adipose tissue contained elevated numbers of ILC2, eosinophils and M2 macrophages. Underscoring the protective phenotype of M2-skewed macrophages, the transfer of TACI KO macrophages into obese WT mouse significantly improved insulin sensitivity and glucose tolerance in WT mouse. Interestingly, adoptively transferred TACI KO macrophages into WT mice also increased numbers of the host M2 macrophages and eosinophils in the adipose tissue. We identified IL-10 secreted by TACI KO macrophages was majorly responsible for the improved insulin sensitivity because not only TACI KO macrophage culture media contained high levels of IL-10 but also an IL-10 blocking antibody abolished the enhancement of insulin signaling provided by TACI KO macrophage culture media. These findings indicate that macrophage TACI mediated inflammatory signals promote obesity induced metabolic changes. Consequently, TACI blocking reagents may offer therapeutic benefits to obese patients suffering from metabolic complications." @default.
- W4313359949 created "2023-01-06" @default.
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- W4313359949 date "2017-05-01" @default.
- W4313359949 modified "2023-09-25" @default.
- W4313359949 title "TACI-deficient macrophages alleviate metabolic disease symptoms in obese mice" @default.
- W4313359949 doi "https://doi.org/10.4049/jimmunol.198.supp.207.6" @default.
- W4313359949 hasPublicationYear "2017" @default.
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