FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313359966> ?p ?o ?g. }

• W4313359966 endingPage "54.1" @default.
• W4313359966 startingPage "54.1" @default.
• W4313359966 abstract "Abstract Autoantibodies that arise in autoimmunity can be present years to decades prior to the onset of disease manifestations. This suggests that the initial autoimmune trigger involves a peripheral lymphoid component, which ultimately drives disease pathology in local tissues later in life. Here we show Sjögren’s Syndrome manifestations that develop in aged NOD.H-2h4 mice were driven by and dependent on peripheral dysregulation that arose in early life. Specifically, elimination of spontaneous germinal centers that developed in spleens of young NOD.H-2h4 mice by transient blockade of CD40 ligand (CD40L) or splenectomy abolished Sjögren’s pathology of aged mice. Strikingly, a single injection of anti-CD40L at 4 weeks-of-age prevented tertiary follicle neogenesis and greatly blunted the formation of key autoantibodies implicated in glandular pathology. Microarray profiling of salivary gland characterized the expression pattern of genes that increased with disease progression and showed early anti-CD40L greatly repressed B cell function, while having a broader effect on multiple biological pathways including IL-12 and interferon signaling. Importantly, a single, prophylactic treatment with anti-CD40L also inhibited the development of autoimmune thyroiditis and diabetes in NOD.H-2h4 and NOD mice, respectively, supporting a key role for CD40L in the pathophysiology of several autoimmune models. These results suggest that early peripheral immune dysregulation gives rise to autoimmune manifestations later in life and for diseases pre-dated by autoantibodies, early prophylactic intervention with biologics may prove efficacious." @default.
• W4313359966 created "2023-01-06" @default.
• W4313359966 creator A5004692206 @default.
• W4313359966 creator A5005264713 @default.
• W4313359966 creator A5011894823 @default.
• W4313359966 creator A5019704254 @default.
• W4313359966 creator A5021993819 @default.
• W4313359966 creator A5026286781 @default.
• W4313359966 creator A5040898659 @default.
• W4313359966 creator A5048188574 @default.
• W4313359966 creator A5056194172 @default.
• W4313359966 creator A5060145442 @default.
• W4313359966 creator A5064970901 @default.
• W4313359966 creator A5068411928 @default.
• W4313359966 creator A5072529054 @default.
• W4313359966 creator A5072615508 @default.
• W4313359966 creator A5073755118 @default.
• W4313359966 creator A5081491801 @default.
• W4313359966 creator A5085976480 @default.
• W4313359966 creator A5086530111 @default.
• W4313359966 creator A5086534495 @default.
• W4313359966 date "2017-05-01" @default.
• W4313359966 modified "2023-10-18" @default.
• W4313359966 title "Autoimmune manifestations in aged mice arise from early-life immune dysregulation" @default.
• W4313359966 doi "https://doi.org/10.4049/jimmunol.198.supp.54.1" @default.
• W4313359966 hasPublicationYear "2017" @default.
• W4313359966 type Work @default.
• W4313359966 citedByCount "0" @default.
• W4313359966 crossrefType "journal-article" @default.
• W4313359966 hasAuthorship W4313359966A5004692206 @default.
• W4313359966 hasAuthorship W4313359966A5005264713 @default.
• W4313359966 hasAuthorship W4313359966A5011894823 @default.
• W4313359966 hasAuthorship W4313359966A5019704254 @default.
• W4313359966 hasAuthorship W4313359966A5021993819 @default.
• W4313359966 hasAuthorship W4313359966A5026286781 @default.
• W4313359966 hasAuthorship W4313359966A5040898659 @default.
• W4313359966 hasAuthorship W4313359966A5048188574 @default.
• W4313359966 hasAuthorship W4313359966A5056194172 @default.
• W4313359966 hasAuthorship W4313359966A5060145442 @default.
• W4313359966 hasAuthorship W4313359966A5064970901 @default.
• W4313359966 hasAuthorship W4313359966A5068411928 @default.
• W4313359966 hasAuthorship W4313359966A5072529054 @default.
• W4313359966 hasAuthorship W4313359966A5072615508 @default.
• W4313359966 hasAuthorship W4313359966A5073755118 @default.
• W4313359966 hasAuthorship W4313359966A5081491801 @default.
• W4313359966 hasAuthorship W4313359966A5085976480 @default.
• W4313359966 hasAuthorship W4313359966A5086530111 @default.
• W4313359966 hasAuthorship W4313359966A5086534495 @default.
• W4313359966 hasConcept C134018914 @default.
• W4313359966 hasConcept C154317977 @default.
• W4313359966 hasConcept C159654299 @default.
• W4313359966 hasConcept C163764329 @default.
• W4313359966 hasConcept C202751555 @default.
• W4313359966 hasConcept C203014093 @default.
• W4313359966 hasConcept C2777016536 @default.
• W4313359966 hasConcept C2778013207 @default.
• W4313359966 hasConcept C2778453870 @default.
• W4313359966 hasConcept C2779075594 @default.
• W4313359966 hasConcept C2780130043 @default.
• W4313359966 hasConcept C2780194698 @default.
• W4313359966 hasConcept C39347974 @default.
• W4313359966 hasConcept C55493867 @default.
• W4313359966 hasConcept C555293320 @default.
• W4313359966 hasConcept C55851684 @default.
• W4313359966 hasConcept C71924100 @default.
• W4313359966 hasConcept C86803240 @default.
• W4313359966 hasConcept C8891405 @default.
• W4313359966 hasConcept C96926380 @default.
• W4313359966 hasConceptScore W4313359966C134018914 @default.
• W4313359966 hasConceptScore W4313359966C154317977 @default.
• W4313359966 hasConceptScore W4313359966C159654299 @default.
• W4313359966 hasConceptScore W4313359966C163764329 @default.
• W4313359966 hasConceptScore W4313359966C202751555 @default.
• W4313359966 hasConceptScore W4313359966C203014093 @default.
• W4313359966 hasConceptScore W4313359966C2777016536 @default.
• W4313359966 hasConceptScore W4313359966C2778013207 @default.
• W4313359966 hasConceptScore W4313359966C2778453870 @default.
• W4313359966 hasConceptScore W4313359966C2779075594 @default.
• W4313359966 hasConceptScore W4313359966C2780130043 @default.
• W4313359966 hasConceptScore W4313359966C2780194698 @default.
• W4313359966 hasConceptScore W4313359966C39347974 @default.
• W4313359966 hasConceptScore W4313359966C55493867 @default.
• W4313359966 hasConceptScore W4313359966C555293320 @default.
• W4313359966 hasConceptScore W4313359966C55851684 @default.
• W4313359966 hasConceptScore W4313359966C71924100 @default.
• W4313359966 hasConceptScore W4313359966C86803240 @default.
• W4313359966 hasConceptScore W4313359966C8891405 @default.
• W4313359966 hasConceptScore W4313359966C96926380 @default.
• W4313359966 hasIssue "1_Supplement" @default.
• W4313359966 hasLocation W43133599661 @default.
• W4313359966 hasOpenAccess W4313359966 @default.
• W4313359966 hasPrimaryLocation W43133599661 @default.
• W4313359966 hasRelatedWork W1575228872 @default.
• W4313359966 hasRelatedWork W2058746720 @default.
• W4313359966 hasRelatedWork W2169556694 @default.
• W4313359966 hasRelatedWork W2213860064 @default.
• W4313359966 hasRelatedWork W2518196601 @default.
• W4313359966 hasRelatedWork W2536704990 @default.

• next