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- W4313359997 abstract "Abstract Innate lymphoid cells (ILCs) play important roles in host defense, tissue repair, metabolic homeostasis and inflammatory diseases. While ILCs are generally considered to mediate these functions in a tissue-resident manner, whether ILCs can move between sites when infection demands has not been carefully explored. We have reported the existence of an ILC population, inflammatory ILC2 (iILC2) cells, which are not present in the steady state but appear in high numbers in lung, liver, mesenteric lymph nodes and spleen upon IL-25 or Nippostongylus brasiliensis infection. iILC2 cells develop into natural ILC2-like cells and contribute to the expulsion of N. brasiliensis worms. They can also acquire IL-17-producing ability and provide protection against Candida albicans, indicating their multipotentiality or plasticity. Our recent data reveals that iILC2 cells are circulating cells, exchanging to a much greater extent between parabiotic mice than other ILC populations. iILC2 cells that appear after IL-25 administration or helminthic infection in peripheral, non-gut tissues such as the lung arise from distant resting ILC2 cells residing in the intestinal lamina propria. IL-25 induces rapid proliferation of these intestinal ILC2 cells and a change in their sensitivity to S1P-mediated chemotaxis, leading to lymphatic entry, blood circulation, and accumulation in many non-gut sites. These gut-derived cells are critical for anti-helminth immunity and tissue repair in the bowel and lung. Thus, inflammatory ILC2 cells are a circulating ILC population that is derived from the intestine but plays important roles in peripheral tissue host defense. This work was supported by the Intramural Research Program of NIAID, NIH and by the USDA." @default.
- W4313359997 created "2023-01-06" @default.
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- W4313359997 date "2017-05-01" @default.
- W4313359997 modified "2023-10-15" @default.
- W4313359997 title "Inflammatory ILC2: An IL-25-activated circulating ILC population with a protective role during helminthic infection" @default.
- W4313359997 doi "https://doi.org/10.4049/jimmunol.198.supp.68.13" @default.
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