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- W4313360029 abstract "Abstract Immune response to microbial disturbance in the gut involves coordinated activity of gut epithelial cells, motile immune cells and other cells throughout the organism. Many of these functions are ancient among bilaterians, although it is not yet clear how they relate among animal phyla. As morphologically simple organisms that share an important genetic heritage with vertebrates, sea urchin larvae offer a novel, experimentally tractable system in which to characterize the gut-associated immune response. We have developed a model to characterize gene regulatory control of this response using the marine bacterium Vibrio diazotrophicus. When exposed to Vibrio in the surrounding seawater, bacteria accumulate in the gut and later invade the body cavity. Bacteria that enter the blastocoel are rapidly cleared by a coordinated response of phagocytic and granular immune cells. Peripheral immune cells migrate through the body cavity and accumulate at the gut. RNA-Seq data indicate that the most acutely upregulated gene in the early phase of response are two types of IL17 genes. Whole mount in situ hybridization and BAC-based fluorescent protein reporters indicate that these genes are expressed within gut epithelial cells. Notably, perturbation of IL17 receptor signaling results in reduced levels of tnfaip3 (a negative feedback inhibitor of IL17), nfkbiz (an IL17 target gene in vertebrates), the transcription factors cebpα and cebpγ and soul1 (SOUL domains are evolutionarily widespread and involved in immune responses). These results indicate that the highly regulated IL17 expression in the gut epithelium and signaling through IL17R1 form a central axis of larval gut-associated immunity." @default.
- W4313360029 created "2023-01-06" @default.
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- W4313360029 date "2017-05-01" @default.
- W4313360029 modified "2023-09-23" @default.
- W4313360029 title "Epithelial expression of IL-17 mediates a gut-associated inflammatory response in the purple sea urchin larva." @default.
- W4313360029 doi "https://doi.org/10.4049/jimmunol.198.supp.226.24" @default.
- W4313360029 hasPublicationYear "2017" @default.
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