Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313360061> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W4313360061 endingPage "66.22" @default.
- W4313360061 startingPage "66.22" @default.
- W4313360061 abstract "Abstract Elevated levels of Interleukin 22 (IL-22) and its receptor (IL-22R) are associated with poor prognosis in pancreatic ductal adenocarcinoma (PDAC) and the underlying mechanism is currently unknown. Our aim is to investigate the role of the IL-22 axis in PDAC initiation and progression. Impact of IL-22 on tumor initiation was assayed by subcutaneous and intravenous inoculation of PDAC cells into wild-type and IL-22−/− mice. The PKCY (Pdx1-Cre; KrasG12D; p53fl/+; RosaYFP) model of pancreas cancer was used to study the in-vivo presence and significance of IL-22 in spontaneous tumors. Results were confirmed in human specimens of surgically resected pancreas cancer. IL-22R was present in all tested PDAC lines and IL-22 treatment led to STAT3 phosphorylation and subsequent increased expression of EMT (Epithelial to Mesenchymal Transition) transcription factors. Cells transitioned to a mesenchymal phenotype and robust tumor sphere formation was observed. While tumors readily formed in wild-type mice, initiation, establishment and growth were impaired in IL-22−/− mice and PKCY-IL-22−/− mice. Increased levels of IL-22 were found in both spontaneous murine tumors and surgical specimens compared to control tissue. IHC of tumors showed diffuse IL-22R staining with increasing intensity of pSTAT3 and EMT markers as tumors progressed to invasive cancer. FACS analysis identified type 3 innate lymphoid cells and TH22 cells as the source of IL-22 in both human and murine PDAC. Our data suggests that IL-22 is integral in the initiation, progression and establishment of pancreatic cancer, positioning it as an attractive target for cancer therapy." @default.
- W4313360061 created "2023-01-06" @default.
- W4313360061 creator A5005093063 @default.
- W4313360061 creator A5017507018 @default.
- W4313360061 creator A5028420557 @default.
- W4313360061 creator A5041384981 @default.
- W4313360061 creator A5070137893 @default.
- W4313360061 creator A5072368632 @default.
- W4313360061 creator A5088147590 @default.
- W4313360061 creator A5089427330 @default.
- W4313360061 date "2017-05-01" @default.
- W4313360061 modified "2023-09-27" @default.
- W4313360061 title "IL-22 Promotes Pancreatic Cancer Tumorigenesis through Induction of Stemness and Epithelial to Mesenchymal Transition" @default.
- W4313360061 doi "https://doi.org/10.4049/jimmunol.198.supp.66.22" @default.
- W4313360061 hasPublicationYear "2017" @default.
- W4313360061 type Work @default.
- W4313360061 citedByCount "0" @default.
- W4313360061 crossrefType "journal-article" @default.
- W4313360061 hasAuthorship W4313360061A5005093063 @default.
- W4313360061 hasAuthorship W4313360061A5017507018 @default.
- W4313360061 hasAuthorship W4313360061A5028420557 @default.
- W4313360061 hasAuthorship W4313360061A5041384981 @default.
- W4313360061 hasAuthorship W4313360061A5070137893 @default.
- W4313360061 hasAuthorship W4313360061A5072368632 @default.
- W4313360061 hasAuthorship W4313360061A5088147590 @default.
- W4313360061 hasAuthorship W4313360061A5089427330 @default.
- W4313360061 hasConcept C11960822 @default.
- W4313360061 hasConcept C121608353 @default.
- W4313360061 hasConcept C134018914 @default.
- W4313360061 hasConcept C142724271 @default.
- W4313360061 hasConcept C198826908 @default.
- W4313360061 hasConcept C2778764654 @default.
- W4313360061 hasConcept C2778923194 @default.
- W4313360061 hasConcept C2779013556 @default.
- W4313360061 hasConcept C2779256057 @default.
- W4313360061 hasConcept C2780210213 @default.
- W4313360061 hasConcept C502942594 @default.
- W4313360061 hasConcept C54355233 @default.
- W4313360061 hasConcept C555283112 @default.
- W4313360061 hasConcept C71924100 @default.
- W4313360061 hasConcept C76419328 @default.
- W4313360061 hasConcept C86803240 @default.
- W4313360061 hasConcept C95444343 @default.
- W4313360061 hasConcept C96232424 @default.
- W4313360061 hasConceptScore W4313360061C11960822 @default.
- W4313360061 hasConceptScore W4313360061C121608353 @default.
- W4313360061 hasConceptScore W4313360061C134018914 @default.
- W4313360061 hasConceptScore W4313360061C142724271 @default.
- W4313360061 hasConceptScore W4313360061C198826908 @default.
- W4313360061 hasConceptScore W4313360061C2778764654 @default.
- W4313360061 hasConceptScore W4313360061C2778923194 @default.
- W4313360061 hasConceptScore W4313360061C2779013556 @default.
- W4313360061 hasConceptScore W4313360061C2779256057 @default.
- W4313360061 hasConceptScore W4313360061C2780210213 @default.
- W4313360061 hasConceptScore W4313360061C502942594 @default.
- W4313360061 hasConceptScore W4313360061C54355233 @default.
- W4313360061 hasConceptScore W4313360061C555283112 @default.
- W4313360061 hasConceptScore W4313360061C71924100 @default.
- W4313360061 hasConceptScore W4313360061C76419328 @default.
- W4313360061 hasConceptScore W4313360061C86803240 @default.
- W4313360061 hasConceptScore W4313360061C95444343 @default.
- W4313360061 hasConceptScore W4313360061C96232424 @default.
- W4313360061 hasIssue "1_Supplement" @default.
- W4313360061 hasLocation W43133600611 @default.
- W4313360061 hasOpenAccess W4313360061 @default.
- W4313360061 hasPrimaryLocation W43133600611 @default.
- W4313360061 hasRelatedWork W1499339123 @default.
- W4313360061 hasRelatedWork W1912771734 @default.
- W4313360061 hasRelatedWork W2003068239 @default.
- W4313360061 hasRelatedWork W2154708791 @default.
- W4313360061 hasRelatedWork W2201282822 @default.
- W4313360061 hasRelatedWork W2337105312 @default.
- W4313360061 hasRelatedWork W2582912872 @default.
- W4313360061 hasRelatedWork W2587319667 @default.
- W4313360061 hasRelatedWork W2600717990 @default.
- W4313360061 hasRelatedWork W2806814376 @default.
- W4313360061 hasVolume "198" @default.
- W4313360061 isParatext "false" @default.
- W4313360061 isRetracted "false" @default.
- W4313360061 workType "article" @default.