Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313360065> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4313360065 endingPage "78.1" @default.
- W4313360065 startingPage "78.1" @default.
- W4313360065 abstract "Abstract There is a growing interest in the role of MHC class Ib-restricted CD8+ T cells, referred to as non-classical T cells, such as MAIT cells and NKT cells. Non-classical CD8+ T cells have been shown to participate during the immune response towards a number of bacterial and viral pathogens. However, the overall role of these cells remains largely undetermined. We sought to investigate their contribution during murine cytomegalovirus (MCMV) infection, a well-established model for human cytomegalovirus. To circumvent the known role of conventional CD8+ T cells we utilize KbDb−/− mice, which lack MHC class Ia molecules. Following MCMV challenge, a subset of non-classical CD8+ T cells undergoes robust expansion, gains effector functions, and subsequently contracts. Interestingly, there is a prolonged inflammatory phenotype not observed in B6 or β2m−/− control animals. Non-classical CD8+ T cells from long-term infected KbDb−/− mice are also capable of robust proliferation in response to secondary MCMV infection, indicating that these T cells exhibit a memory phenotype. Using RAGKbDb−/− animals, we determined that adoptively transferred non-classical CD8+ T cells are sufficient to protect against MCMV-induced lethality. The population we describe is more phenotypically similar to conventional CD8+ T cells than innate non-classical T cells. Altogether, our data indicate that MHC class Ib-restricted CD8+ T cells may substitute for conventional CD8+ T cells when their functions are compromised during CMV immunoevasion." @default.
- W4313360065 created "2023-01-06" @default.
- W4313360065 creator A5049998698 @default.
- W4313360065 creator A5061473047 @default.
- W4313360065 creator A5066315967 @default.
- W4313360065 creator A5071161157 @default.
- W4313360065 creator A5080591704 @default.
- W4313360065 date "2017-05-01" @default.
- W4313360065 modified "2023-10-14" @default.
- W4313360065 title "The non-classical CD8+ T cell response to murine cytomegalovirus" @default.
- W4313360065 doi "https://doi.org/10.4049/jimmunol.198.supp.78.1" @default.
- W4313360065 hasPublicationYear "2017" @default.
- W4313360065 type Work @default.
- W4313360065 citedByCount "0" @default.
- W4313360065 crossrefType "journal-article" @default.
- W4313360065 hasAuthorship W4313360065A5049998698 @default.
- W4313360065 hasAuthorship W4313360065A5061473047 @default.
- W4313360065 hasAuthorship W4313360065A5066315967 @default.
- W4313360065 hasAuthorship W4313360065A5071161157 @default.
- W4313360065 hasAuthorship W4313360065A5080591704 @default.
- W4313360065 hasConcept C129374314 @default.
- W4313360065 hasConcept C139563560 @default.
- W4313360065 hasConcept C148125776 @default.
- W4313360065 hasConcept C154317977 @default.
- W4313360065 hasConcept C159047783 @default.
- W4313360065 hasConcept C167672396 @default.
- W4313360065 hasConcept C170627219 @default.
- W4313360065 hasConcept C202751555 @default.
- W4313360065 hasConcept C203014093 @default.
- W4313360065 hasConcept C207936829 @default.
- W4313360065 hasConcept C2776090121 @default.
- W4313360065 hasConcept C2908647359 @default.
- W4313360065 hasConcept C54355233 @default.
- W4313360065 hasConcept C71924100 @default.
- W4313360065 hasConcept C86803240 @default.
- W4313360065 hasConcept C8891405 @default.
- W4313360065 hasConcept C95444343 @default.
- W4313360065 hasConcept C99454951 @default.
- W4313360065 hasConceptScore W4313360065C129374314 @default.
- W4313360065 hasConceptScore W4313360065C139563560 @default.
- W4313360065 hasConceptScore W4313360065C148125776 @default.
- W4313360065 hasConceptScore W4313360065C154317977 @default.
- W4313360065 hasConceptScore W4313360065C159047783 @default.
- W4313360065 hasConceptScore W4313360065C167672396 @default.
- W4313360065 hasConceptScore W4313360065C170627219 @default.
- W4313360065 hasConceptScore W4313360065C202751555 @default.
- W4313360065 hasConceptScore W4313360065C203014093 @default.
- W4313360065 hasConceptScore W4313360065C207936829 @default.
- W4313360065 hasConceptScore W4313360065C2776090121 @default.
- W4313360065 hasConceptScore W4313360065C2908647359 @default.
- W4313360065 hasConceptScore W4313360065C54355233 @default.
- W4313360065 hasConceptScore W4313360065C71924100 @default.
- W4313360065 hasConceptScore W4313360065C86803240 @default.
- W4313360065 hasConceptScore W4313360065C8891405 @default.
- W4313360065 hasConceptScore W4313360065C95444343 @default.
- W4313360065 hasConceptScore W4313360065C99454951 @default.
- W4313360065 hasIssue "1_Supplement" @default.
- W4313360065 hasLocation W43133600651 @default.
- W4313360065 hasOpenAccess W4313360065 @default.
- W4313360065 hasPrimaryLocation W43133600651 @default.
- W4313360065 hasRelatedWork W117153048 @default.
- W4313360065 hasRelatedWork W1953155836 @default.
- W4313360065 hasRelatedWork W1982121321 @default.
- W4313360065 hasRelatedWork W2009442797 @default.
- W4313360065 hasRelatedWork W2093116728 @default.
- W4313360065 hasRelatedWork W2140041178 @default.
- W4313360065 hasRelatedWork W2366412323 @default.
- W4313360065 hasRelatedWork W2821255169 @default.
- W4313360065 hasRelatedWork W4313360065 @default.
- W4313360065 hasRelatedWork W2783849630 @default.
- W4313360065 hasVolume "198" @default.
- W4313360065 isParatext "false" @default.
- W4313360065 isRetracted "false" @default.
- W4313360065 workType "article" @default.