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- W4313360066 abstract "Abstract Sjögren’s syndrome (SS) is the second most common rheumatic autoimmune disease with a broad spectrum of clinical and serological manifestations and no approved biologics. To better understand the pathogenesis of SS and explore potential soluble biomarkers and therapeutic targets, sera from 109 SS and 50 healthy controls (HC) were examined. Comprehensive profiling was performed using autoantigen and proteomic arrays (UTSW, 95 autoAb’s; RBM’s, 165 proteins; and SOMAscan, 1129 protein). Data showed that autoAb’s against U1sn-RNP-BB’, U1sn-RNP-C and Ribo phaspho protein P1 significantly increased in SS compared to HC (Fold change >1.5 and FDR <0.05) that positively correlate with FOCUS disease score (FDR<0.05). RBM and SOMAscan was highly consistent and detected 123 unique proteins up-or down-regulated in SS compared to HC. Strikingly, 71 were interferon-regulated proteins, with IP10 correlating best with FOCUS score (r=0.65). Pathway and network analysis also confirmed strong activation of type I interferon signaling. Type I interferon signature genes were also observed in salivary gland of the NOD.H-2h4 mice, a model that closely resembles human SS. Additional proteins dysregulated in SS patent sera include the TNF signaling, antimicrobial proteins A2M and B2M, and multiple SLAMF family members, which may shed light on disease mechanisms and novel therapeutic strategies." @default.
- W4313360066 created "2023-01-06" @default.
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- W4313360066 date "2017-05-01" @default.
- W4313360066 modified "2023-09-30" @default.
- W4313360066 title "Comprehensive proteomic profiling of Sjogren’s syndrome revealed dysregulation of interferon and other immunologic pathways" @default.
- W4313360066 doi "https://doi.org/10.4049/jimmunol.198.supp.55.17" @default.
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