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- W4313360094 abstract "Abstract Chemokines mediate the important roles in organ-specific homing of various cancer cells, including ovarian cancer (OvCa) to distant organs that may favor or inhibit cancer progression and metastasis. Hypoxia, a common phenomenon in solid tumors, is associated with a malignant cancer phenotype. Here, we provided the evidence that hypoxia up-regulate CX3CR1 expression and lead to an increased chemotactic response to CX3CL1 in OvCa cells. Hypoxia- induced genes are widely involved in metastasis-associated functions; and also undergo epithelial-to-mesenchymal transition (EMT). In the present study, we found that CX3CR1 expression was significantly increased in OvCa cells (OVCAR-3, SW626 and TOV-112D) following exposure to hypoxia. Flow cytometry, RT-PCR, western blot, Immunohistochemistry and immunofluorescence techniques were used to quantify the expression of chemokine CX3CR1and CX3CL1 in OvCa. Moreover, a significant higher expression of CX3CR1 under hypoxia compared to the normoxic condition in OvCa. Furthermore, we demonstrated that OvCa cells display a marked increase in hypoxia-induced CX3CR1-dependent PI3K/Akt/mTOR and MAPK signaling molecules as well as EMT markers and matrix metalloproteinase (MMPs) which are involved in cancer progression and metastasis of OvCa cells in hypoxic condition. These data demonstrate hypoxia pathway regulate the expression of CX3CR1 that may contribute to progression and metastasis of OvCa." @default.
- W4313360094 created "2023-01-06" @default.
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- W4313360094 date "2017-05-01" @default.
- W4313360094 modified "2023-09-27" @default.
- W4313360094 title "Hypoxia-inducible factor-1 mediated CX3CR1 expression correlates with progression and metastasis in ovarian cancer" @default.
- W4313360094 doi "https://doi.org/10.4049/jimmunol.198.supp.63.5" @default.
- W4313360094 hasPublicationYear "2017" @default.
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