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- W4313360110 abstract "Abstract Cancer cells express vacuolar ATPase (V-ATPase), a multi-subunit proton pump on the plasma membrane and intracellularly on vesicular membranes. The V-ATPases are responsible for acidification of intracellular vesicles and in certain activated cells are expressed on the surface where they appear to acidify the extracellular environment. The N-terminal domain of the a2 isoform of V-ATPase (a2NTD) is cleaved and secreted in exosomes. a2NTD has immunomodulatory effects on monocytes, macrophages and neutrophils. The changes elicited by a2NTD play an important role during pregnancy and cancer/tumor progression. To further investigate whether a2NTD has an effect on recruitment or stimulation of MDSCs in vivo, we injected a2NTD into the peritoneum of mice and analyzed CD11b+ myeloid cell populations. Here we observed that, intra-peritoneal (i.p.) administration of recombinant a2NTD protein results in recruitment of significantly higher number of CD11b+Ly6G+Ly6C+ MDSC like cells to the peritoneal cavity. We show that these cells are different from neutrophils by their expression of Ly6C on their surface. However, the total percent of CD11b+ cells or CD11b+F4/80+ macrophages remained unchanged. In vitro results demonstrate that addition of recombinant a2NTD protein to primary bone marrow derived macrophages (BMMs) from C57BL/6 mice leads to secretion of anti-inflammatory cytokine IL-10. Collectively, these results demonstrate that a2NTD administration leads to an immunosuppressive environment that might facilitate tumor progression. Further study is needed to understand the mechanism by which a2NTD modulates the MDSC like cells and creates an immunosuppressive pro-tumorigenic environment." @default.
- W4313360110 created "2023-01-06" @default.
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- W4313360110 date "2017-05-01" @default.
- W4313360110 modified "2023-09-23" @default.
- W4313360110 title "Cancer derived peptide of vacuolar ATPase ‘a2’ isoform plays immunosuppressive role by recruiting myeloid derived suppressor like cells" @default.
- W4313360110 doi "https://doi.org/10.4049/jimmunol.198.supp.76.18" @default.
- W4313360110 hasPublicationYear "2017" @default.
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