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- W4313360139 abstract "Abstract Upon contact to antigen, B cells differentiate into memory B cells or antibody secreting short-lived or long-lived plasma cells (PC). The survival of long-lived PCs depends on interaction with survival niches in the spleen or in the bone marrow. However, the molecular mechanisms controlling PC generation, migration, homing and survival are poorly understood. We recently reported that Krueppel-like factor 2 (KLF2) is an important regulator of PC homeostasis. KLF2-deficient B cells express lower levels of homing factors, such as beta7-Integrin and L-Selectin. Numbers of antigen-specific PCs in the bone marrow of immunized KLF2-deficient mice are drastically reduced, indicating that KLF2 plays a crucial role in controlling PC homing and/or survival. Based on these findings we wanted to further characterize the functional impact of KLF2 on B cell activation and PC homeostasis. We observed that KLF2-deficient follicular B cells show a lower activation threshold and differentiate faster into plasma blasts in response to lower LPS concentrations in vitro compared to wildtype B cells. Furthermore, KLF2-deficient B cells proliferate faster as measured by CFSE. Target genes and signalling pathways modulated by KLF2 in B cells and PCs are currently analysed by gene expression profiling. We conclude that KLF2 acts as a quiescence factor in mature B cells by setting their activation threshold. In addition, KLF2 is crucial for PC homeostasis. KLF2-mediated signalling pathways and KLF2-regulated target genes which set the threshold for B cell activation, regulate plasma blast homing and mediate plasma cell survival will be identified by transcriptome analyses. This study was supported by DFG grants FOR832 and TRR130 to H.-M.J. and ELAN grant to W.S." @default.
- W4313360139 created "2023-01-06" @default.
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- W4313360139 date "2017-05-01" @default.
- W4313360139 modified "2023-09-27" @default.
- W4313360139 title "The role of Krueppel-like factor 2 in B cell activation and plasma cell homeostasis" @default.
- W4313360139 doi "https://doi.org/10.4049/jimmunol.198.supp.74.9" @default.
- W4313360139 hasPublicationYear "2017" @default.
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