Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313360203> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W4313360203 endingPage "123.13" @default.
- W4313360203 startingPage "123.13" @default.
- W4313360203 abstract "Abstract Malaria is still one of leading infectious diseases in the world being a great global health burden. Pathological anemia is one of the most common malaria-associated complications, which accounts to both great morbidity and mortality of the infection. Our lab has recently identified autoantibodies that target the membrane lipid phosphatidylserine (PS) on uninfected erythrocytes as a major promoter of malarial anemia both in a rodent model and correlating with P. falciparum malarial anemia in patients. The aim of this work was to identify the population of B-cells that are responsible for the production of these autoantibodies as well as characterizing the mechanism by which they arise during malarial infection. Our results have identified an atypical population of B-cells expressing the transcription factor T-bet as being major producers of anti-PS antibodies during malarial anemia. Additionally we have identified parasite DNA along with inflammatory cytokine IFNγ as essential signals that synergize to promote the development and appearance of these autoreactive T-bet+ B-cells. Similarly, the lack of any of these signals ameliorated severe anemia during a rodent malarial infection model. We have also identified both expansion of T-bet+ B-cells and production of anti-PS antibodies in ex-vivo cultures of naïve human PBMCs exposed to P. falciprum infected erythrocyte lysates. Lastly, we have also observed the expansion of T-bet+ B-cells correlating with both anti-PS antibodies and anemia during rodent trypanosoma (T. brucei) infection. These results provide mechanistic insights about the appearance of autoimmunity during infection and attribute a role for autoimmunity in contributing to pathology during parasitic infections." @default.
- W4313360203 created "2023-01-06" @default.
- W4313360203 creator A5012424947 @default.
- W4313360203 creator A5015192058 @default.
- W4313360203 creator A5048023731 @default.
- W4313360203 creator A5069573534 @default.
- W4313360203 date "2017-05-01" @default.
- W4313360203 modified "2023-09-25" @default.
- W4313360203 title "Autoreactive T-bet+ B-cells promote pathological anemia during infection" @default.
- W4313360203 doi "https://doi.org/10.4049/jimmunol.198.supp.123.13" @default.
- W4313360203 hasPublicationYear "2017" @default.
- W4313360203 type Work @default.
- W4313360203 citedByCount "0" @default.
- W4313360203 crossrefType "journal-article" @default.
- W4313360203 hasAuthorship W4313360203A5012424947 @default.
- W4313360203 hasAuthorship W4313360203A5015192058 @default.
- W4313360203 hasAuthorship W4313360203A5048023731 @default.
- W4313360203 hasAuthorship W4313360203A5069573534 @default.
- W4313360203 hasConcept C126322002 @default.
- W4313360203 hasConcept C159047783 @default.
- W4313360203 hasConcept C159654299 @default.
- W4313360203 hasConcept C163764329 @default.
- W4313360203 hasConcept C203014093 @default.
- W4313360203 hasConcept C2778048844 @default.
- W4313360203 hasConcept C2778248108 @default.
- W4313360203 hasConcept C2778371730 @default.
- W4313360203 hasConcept C2908647359 @default.
- W4313360203 hasConcept C71924100 @default.
- W4313360203 hasConcept C86803240 @default.
- W4313360203 hasConcept C99454951 @default.
- W4313360203 hasConceptScore W4313360203C126322002 @default.
- W4313360203 hasConceptScore W4313360203C159047783 @default.
- W4313360203 hasConceptScore W4313360203C159654299 @default.
- W4313360203 hasConceptScore W4313360203C163764329 @default.
- W4313360203 hasConceptScore W4313360203C203014093 @default.
- W4313360203 hasConceptScore W4313360203C2778048844 @default.
- W4313360203 hasConceptScore W4313360203C2778248108 @default.
- W4313360203 hasConceptScore W4313360203C2778371730 @default.
- W4313360203 hasConceptScore W4313360203C2908647359 @default.
- W4313360203 hasConceptScore W4313360203C71924100 @default.
- W4313360203 hasConceptScore W4313360203C86803240 @default.
- W4313360203 hasConceptScore W4313360203C99454951 @default.
- W4313360203 hasIssue "1_Supplement" @default.
- W4313360203 hasLocation W43133602031 @default.
- W4313360203 hasOpenAccess W4313360203 @default.
- W4313360203 hasPrimaryLocation W43133602031 @default.
- W4313360203 hasRelatedWork W2060046542 @default.
- W4313360203 hasRelatedWork W2101875571 @default.
- W4313360203 hasRelatedWork W2107457020 @default.
- W4313360203 hasRelatedWork W2109858985 @default.
- W4313360203 hasRelatedWork W2165065921 @default.
- W4313360203 hasRelatedWork W2463079054 @default.
- W4313360203 hasRelatedWork W4200302535 @default.
- W4313360203 hasRelatedWork W69335772 @default.
- W4313360203 hasRelatedWork W76260333 @default.
- W4313360203 hasRelatedWork W2181217732 @default.
- W4313360203 hasVolume "198" @default.
- W4313360203 isParatext "false" @default.
- W4313360203 isRetracted "false" @default.
- W4313360203 workType "article" @default.