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- W4313360241 abstract "Abstract Neonates respond poorly to influenza infection and have trouble clearing the virus. In contrast to adult mice, pups display reduced cytokine production and poor migration of cells into the alveolar space during infection, resulting in an interstitial pneumonia and delayed clearance of virus. Pups also have a large population of regulatory T cells (Tregs) in their lungs compared to adults. Tregs suppress immune reactions and their abundance in pups could explain the poor response to infection. However, we found that pups that lacked Tregs failed to clear influenza infection, suggesting that pups require Tregs to clear the virus. We hypothesize that there is a functional difference between adult and pup Tregs that may explain this finding. Tregs express the transcription factor Foxp3, and it is essential for their function, but they may also express T helper subset transcription factors such as Tbet, Gata3 or RORγt. The function of this co-expression is incompletely understood, but they may play a role in establishing functional subsets of Tregs. We investigated whether Tregs from adult mice expressed different transcription factors than Tregs from pups during infection. We performed flow cytometry on cells from the lungs of neonatal and adult mice infected with influenza virus to examine the prevalence of Tregs that co-expressed Foxp3 with Tbet, Gata3 or RORγt. We found that Tregs in pups tended to express Gata3 more frequently than Tregs from adults. In contrast, adult Tregs were more likely to express Tbet or RORγt than pups. We are investigating whether this differential expression of transcription factors has functional consequences in modulating the response to influenza virus." @default.
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- W4313360241 date "2016-05-01" @default.
- W4313360241 modified "2023-09-27" @default.
- W4313360241 title "Differential Tbet, Gata3 and RORγt expression in mature and neonatal regulatory T cells during influenza virus infection" @default.
- W4313360241 doi "https://doi.org/10.4049/jimmunol.196.supp.78.21" @default.
- W4313360241 hasPublicationYear "2016" @default.
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