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- W4313360259 abstract "Abstract Marginal zone (MZ) B cells are an anatomically segregated population well-positioned to respond to blood borne pathogens and implicated in defense against encapsulated bacteria. MZ B cells are also an important source of the anti-inflammatory cytokine, IL-10. As such, these cells are poised to prevent secondary bacterial infection or immune pathology during chronic virus infection. Surprisingly, CD169+ MZ macrophages and CD21+CD23neg B cells were lost in mice during persistent clone 13 lymphocytic choriomeningitis virus (LCMV) infection in the absence of natural killer (NK) cells. Confocal staining revealed a near complete absence of the MZ by day 10 of infection in NKdeficient mice, which we previously found contain enhanced populations of antiviral T cells. Intriguingly, depletion of either CD4 or CD8 T cells did not restore the MZ compartment in NKdeficient mice, but combined depletion of both subsets of T cells prevented the loss. This phenomenon was independent of NKT cells. We hypothesize that NK cells play an important role in curtailing harmful inflammation and preventing pathogenic bacterial diseases during chronic viral infection by sustaining the MZ. This discovery has important implications for health, immune function, and viral clearance during persistent infection." @default.
- W4313360259 created "2023-01-06" @default.
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- W4313360259 date "2016-05-01" @default.
- W4313360259 modified "2023-09-25" @default.
- W4313360259 title "An innate helping hand for B cells on the margin during chronic viral infection" @default.
- W4313360259 doi "https://doi.org/10.4049/jimmunol.196.supp.147.1" @default.
- W4313360259 hasPublicationYear "2016" @default.
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