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- W4313360293 abstract "Abstract Streptococcus pneumoniae (pneumococcus) is frequently found in the human respiratory tract and can cause a wide range of diseases from mild otitis to fatal pneumonia or meningitis. It is estimated that pneumococcus kills 1.6 million people each year, approximately half of whom are children in developing nations. Given that vitamin A deficiency (VAD) occurs in both developed and developing countries, we sought to explore the relationship between VAD and pneumococcal disease. Previously, we have shown that mice with VAD fail to clear respiratory virus infections efficiently, resulting in a prolonged state of inflammation. Here we show that mice with VAD are more likely to develop a severe lung infection following intranasal infection with pneumococcus compared to vitamin A sufficient controls. We also found that VAD increases morbidity and mortality from secondary pneumococcal infections in influenza-infected mice. This increased sensitivity to pneumococcal infections led us to investigate the effectiveness of the human pneumococcal vaccine Prevnar-13 (PCV) in the context of VAD. Vaccinated mice with VAD mounted only minimal IgM and IgG antibody responses toward PCV compared to controls. Upon challenge with an invasive strain (TIGR4) of pneumococcus, vaccinated control animals were nearly 100% protected from disease with no detectable bacteremia at 24 hours post-infection, whereas nearly 1/3 of vaccinated VAD animals developed bacteremia within 24 hours and ultimately succumbed to the infection. Our results suggest that clinical analyses of children in both developed and developing countries should be conducted to ensure that PCV successfully protects against pneumococcal disease in individuals with VAD." @default.
- W4313360293 created "2023-01-06" @default.
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- W4313360293 date "2016-05-01" @default.
- W4313360293 modified "2023-09-23" @default.
- W4313360293 title "Vitamin A deficient mice are highly susceptible to <i>Streptococcus pneumoniae</i> and exhibit a poor response to vaccination with Prevnar-13" @default.
- W4313360293 doi "https://doi.org/10.4049/jimmunol.196.supp.76.4" @default.
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