Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313360295> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4313360295 endingPage "78.15" @default.
- W4313360295 startingPage "78.15" @default.
- W4313360295 abstract "Abstract The generation of strain-specific neutralizing antibodies against influenza A virus is known to confer potent protection against homologous infections. Recently, elicitation of broadly-neutralizing antibodies which target the conserved hemagglutinin stalk domain have emerged as a promising “universal” influenza virus vaccine strategy. The ability of these antibodies to elicit Fc-dependent effector functions, such as antibody-dependent cell-mediated cytotoxicity, has emerged as an important mechanism through which protection is achieved in vivo. However, the way in which Fc-dependent effector functions are regulated by polyclonal influenza-binding antibody idiotypes in vivo has never been defined. Here, we demonstrate that complex interactions among viral glycoprotein-binding antibody idiotypes regulate the magnitude of antibody-dependent cell-mediated cytotoxicity induction. We propose that antibody idiotype serves as a critical determinant in the activation of ADCC. This is the first demonstration that cross-talk among antibody idiotypes is important for the regulation of Fc-dependent effector functions. This phenomenon will have major implications for not only the development of universal influenza virus vaccines, but also in any scenario wherein Fc-dependent effector functions are engaged in the context of polyclonal responses containing multiple antibody idiotypes." @default.
- W4313360295 created "2023-01-06" @default.
- W4313360295 creator A5004404612 @default.
- W4313360295 creator A5007749514 @default.
- W4313360295 creator A5011193563 @default.
- W4313360295 creator A5051472423 @default.
- W4313360295 creator A5066625736 @default.
- W4313360295 creator A5071125492 @default.
- W4313360295 date "2016-05-01" @default.
- W4313360295 modified "2023-09-23" @default.
- W4313360295 title "Antibody idiotype plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity (ADCC) against influenza A virus" @default.
- W4313360295 doi "https://doi.org/10.4049/jimmunol.196.supp.78.15" @default.
- W4313360295 hasPublicationYear "2016" @default.
- W4313360295 type Work @default.
- W4313360295 citedByCount "0" @default.
- W4313360295 crossrefType "journal-article" @default.
- W4313360295 hasAuthorship W4313360295A5004404612 @default.
- W4313360295 hasAuthorship W4313360295A5007749514 @default.
- W4313360295 hasAuthorship W4313360295A5011193563 @default.
- W4313360295 hasAuthorship W4313360295A5051472423 @default.
- W4313360295 hasAuthorship W4313360295A5066625736 @default.
- W4313360295 hasAuthorship W4313360295A5071125492 @default.
- W4313360295 hasConcept C151730666 @default.
- W4313360295 hasConcept C159047783 @default.
- W4313360295 hasConcept C159654299 @default.
- W4313360295 hasConcept C203014093 @default.
- W4313360295 hasConcept C2522874641 @default.
- W4313360295 hasConcept C2777546802 @default.
- W4313360295 hasConcept C2778692840 @default.
- W4313360295 hasConcept C2779343474 @default.
- W4313360295 hasConcept C2910082366 @default.
- W4313360295 hasConcept C40677261 @default.
- W4313360295 hasConcept C51785407 @default.
- W4313360295 hasConcept C542903549 @default.
- W4313360295 hasConcept C74505204 @default.
- W4313360295 hasConcept C86803240 @default.
- W4313360295 hasConcept C956191 @default.
- W4313360295 hasConceptScore W4313360295C151730666 @default.
- W4313360295 hasConceptScore W4313360295C159047783 @default.
- W4313360295 hasConceptScore W4313360295C159654299 @default.
- W4313360295 hasConceptScore W4313360295C203014093 @default.
- W4313360295 hasConceptScore W4313360295C2522874641 @default.
- W4313360295 hasConceptScore W4313360295C2777546802 @default.
- W4313360295 hasConceptScore W4313360295C2778692840 @default.
- W4313360295 hasConceptScore W4313360295C2779343474 @default.
- W4313360295 hasConceptScore W4313360295C2910082366 @default.
- W4313360295 hasConceptScore W4313360295C40677261 @default.
- W4313360295 hasConceptScore W4313360295C51785407 @default.
- W4313360295 hasConceptScore W4313360295C542903549 @default.
- W4313360295 hasConceptScore W4313360295C74505204 @default.
- W4313360295 hasConceptScore W4313360295C86803240 @default.
- W4313360295 hasConceptScore W4313360295C956191 @default.
- W4313360295 hasIssue "1_Supplement" @default.
- W4313360295 hasLocation W43133602951 @default.
- W4313360295 hasOpenAccess W4313360295 @default.
- W4313360295 hasPrimaryLocation W43133602951 @default.
- W4313360295 hasRelatedWork W159415807 @default.
- W4313360295 hasRelatedWork W1988695352 @default.
- W4313360295 hasRelatedWork W2107100610 @default.
- W4313360295 hasRelatedWork W2119177466 @default.
- W4313360295 hasRelatedWork W2139427540 @default.
- W4313360295 hasRelatedWork W2161651891 @default.
- W4313360295 hasRelatedWork W2165045975 @default.
- W4313360295 hasRelatedWork W2204875792 @default.
- W4313360295 hasRelatedWork W2438269483 @default.
- W4313360295 hasRelatedWork W57491688 @default.
- W4313360295 hasVolume "196" @default.
- W4313360295 isParatext "false" @default.
- W4313360295 isRetracted "false" @default.
- W4313360295 workType "article" @default.