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- W4313360306 abstract "Abstract In an acute infection, such as those caused by attenuated vaccines, we should expect the immune response to depend in some manner upon the precursor frequency as well as the magnitude of the viral load within the patient. However, we do not have a quantitative understanding of this process. In a recent study, 80 patients received the yellow fever vaccine and their viral titer and T-cell responses were tracked for several days. It was found that there were substantial differences between individuals in peak viral load, but that the difference in CTL response was relatively small. Moreover, although the CTL response was positively correlated with viral load, the response saturated for high viral loads. Using mathematical models, we investigated which rules of T-cell proliferation could give rise to this pattern. We considered three models: antigen-dependent proliferation in which the T-cells must receive continuous antigen stimulation to continue to divide, programmed proliferation in which T-cells commit to a fixed number of division upon recruitment and a hybrid model in which T-cells commit to a variable number of division based on viral load. We find that this latter model is the most plausible description of the data. We also considered whether negative feedback in the form of T-cell competition may play a role in determining CTL response, however we found no evidence for any such mechanism." @default.
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- W4313360306 date "2016-05-01" @default.
- W4313360306 modified "2023-09-23" @default.
- W4313360306 title "Understanding heterogeneous CTL responses to the yellow fever vaccine using mathematical models." @default.
- W4313360306 doi "https://doi.org/10.4049/jimmunol.196.supp.80.4" @default.
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