Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313360307> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W4313360307 endingPage "80.7" @default.
- W4313360307 startingPage "80.7" @default.
- W4313360307 abstract "Abstract Chikungunya virus (CHIKV) is a positive-sense RNA, arthropod-borne Alphavirus. In recent years the largest recorded outbreak of CHIKV occurred in the Islands of the Indian Ocean and India. CHIKV has continued to spread causing millions of cases across more than 40 countries. Acute symptoms of infection include the abrupt onset of fever, rash, fatigue, headache, backache, and arthralgia, with arthralgia lasting up to several years in some individuals. Ongoing studies analyzing cohorts of CHIKV infected humans have led to a well-developed understanding of the clinical manifestations of CHIKV disease. What is unknown is the role different components of the immune response play in controlling CHIKV dissemination and disease development. In our current study we utilized a non-human primate (NHP) model of CHIKV infection to characterize the early stage of CHIKV infection. Adult male and female rhesus macaques (RM) were infected subcutaneously with CHIKV-LR. Analysis of vRNA loads in joint tissues of infected RM revealed that the highest viral loads were detectable at 2 dpi with at least a log decrease in vRNA levels by 7 dpi. T cells, B cells, PMNs, macrophages, and mast cells were visible in the joints of CHIKV infected RMs at 2 and 7 dpi. To our knowledge this is the first time mast cells have been identified in the tissue of CHIKV infected NHPs. Levels of key proinflammatory cytokines/chemokines were also increased from 3–7 dpi. The gene expression profile in joint tissues reveled an increase in the expression of genes involved in recruitment, activation, and maintenance of mast cells. These findings suggest that infiltration of immune cells including the newly identified mast cells from 2 to 7 dpi assist in controlling CHIKV infection." @default.
- W4313360307 created "2023-01-06" @default.
- W4313360307 creator A5000499524 @default.
- W4313360307 creator A5009204503 @default.
- W4313360307 creator A5012696027 @default.
- W4313360307 creator A5018924367 @default.
- W4313360307 creator A5031015644 @default.
- W4313360307 creator A5036384666 @default.
- W4313360307 creator A5052711186 @default.
- W4313360307 date "2016-05-01" @default.
- W4313360307 modified "2023-09-27" @default.
- W4313360307 title "Mast cells are present during the early stages of Chikungunya virus infection" @default.
- W4313360307 doi "https://doi.org/10.4049/jimmunol.196.supp.80.7" @default.
- W4313360307 hasPublicationYear "2016" @default.
- W4313360307 type Work @default.
- W4313360307 citedByCount "0" @default.
- W4313360307 crossrefType "journal-article" @default.
- W4313360307 hasAuthorship W4313360307A5000499524 @default.
- W4313360307 hasAuthorship W4313360307A5009204503 @default.
- W4313360307 hasAuthorship W4313360307A5012696027 @default.
- W4313360307 hasAuthorship W4313360307A5018924367 @default.
- W4313360307 hasAuthorship W4313360307A5031015644 @default.
- W4313360307 hasAuthorship W4313360307A5036384666 @default.
- W4313360307 hasAuthorship W4313360307A5052711186 @default.
- W4313360307 hasConcept C116675565 @default.
- W4313360307 hasConcept C13373296 @default.
- W4313360307 hasConcept C159047783 @default.
- W4313360307 hasConcept C164027704 @default.
- W4313360307 hasConcept C203014093 @default.
- W4313360307 hasConcept C2522874641 @default.
- W4313360307 hasConcept C2776914184 @default.
- W4313360307 hasConcept C2777474056 @default.
- W4313360307 hasConcept C2781273456 @default.
- W4313360307 hasConcept C2781313946 @default.
- W4313360307 hasConcept C86803240 @default.
- W4313360307 hasConcept C8891405 @default.
- W4313360307 hasConceptScore W4313360307C116675565 @default.
- W4313360307 hasConceptScore W4313360307C13373296 @default.
- W4313360307 hasConceptScore W4313360307C159047783 @default.
- W4313360307 hasConceptScore W4313360307C164027704 @default.
- W4313360307 hasConceptScore W4313360307C203014093 @default.
- W4313360307 hasConceptScore W4313360307C2522874641 @default.
- W4313360307 hasConceptScore W4313360307C2776914184 @default.
- W4313360307 hasConceptScore W4313360307C2777474056 @default.
- W4313360307 hasConceptScore W4313360307C2781273456 @default.
- W4313360307 hasConceptScore W4313360307C2781313946 @default.
- W4313360307 hasConceptScore W4313360307C86803240 @default.
- W4313360307 hasConceptScore W4313360307C8891405 @default.
- W4313360307 hasIssue "1_Supplement" @default.
- W4313360307 hasLocation W43133603071 @default.
- W4313360307 hasOpenAccess W4313360307 @default.
- W4313360307 hasPrimaryLocation W43133603071 @default.
- W4313360307 hasRelatedWork W2002028705 @default.
- W4313360307 hasRelatedWork W2003195502 @default.
- W4313360307 hasRelatedWork W2070324879 @default.
- W4313360307 hasRelatedWork W2356690075 @default.
- W4313360307 hasRelatedWork W2379476474 @default.
- W4313360307 hasRelatedWork W2504702569 @default.
- W4313360307 hasRelatedWork W2739390904 @default.
- W4313360307 hasRelatedWork W2792481890 @default.
- W4313360307 hasRelatedWork W2888598562 @default.
- W4313360307 hasRelatedWork W2181430829 @default.
- W4313360307 hasVolume "196" @default.
- W4313360307 isParatext "false" @default.
- W4313360307 isRetracted "false" @default.
- W4313360307 workType "article" @default.