Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313360314> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W4313360314 endingPage "80.11" @default.
- W4313360314 startingPage "80.11" @default.
- W4313360314 abstract "Abstract The 5′ non-translated region (NTR) is an important molecular determinant that controls replication and virulence of coxsackievirus B (CVB)3. In our studies of CVB3-induced myocarditis, we sought to generate an infectious clone of the virus for routine in vivo experimentation. By determining the viral nucleotide sequence, we identified three new nucleotide substitutions in the clone that differed from the parental virus strain: C97U in the 5′ NTR; a silent mutation, A4327G, in non-structural protein 2C; and C5088U (resulting in P1449L amino acid change) in non-structural protein 3A of the virus leading us to evaluate the role of these changes in the virulence properties of the virus. We noted that the disease-inducing ability of the infectious clone-derived virus in three mouse strains was restricted to pancreatitis alone, and the incidence and severity of myocarditis were significantly reduced. We then reversed the mutations by creating three new clones, representing 1) U97C; 2) G4327A and U5088C; and 3) their combination together in the third clone. The viral titers obtained from all the clones were comparable, but the virions derived from the third clone induced myocarditis comparable to that induced by wild type virus; however, the pancreatitis-inducing ability remained unaltered, suggesting that the mutations described above selectively influence myocarditogenicity. Our data point to a possibility that, CVB3 viruses containing such altered nucleotides may evolve naturally leading to their survival." @default.
- W4313360314 created "2023-01-06" @default.
- W4313360314 creator A5001803460 @default.
- W4313360314 creator A5042986773 @default.
- W4313360314 creator A5047895999 @default.
- W4313360314 creator A5069866852 @default.
- W4313360314 creator A5071995530 @default.
- W4313360314 creator A5082677888 @default.
- W4313360314 creator A5089390018 @default.
- W4313360314 date "2016-05-01" @default.
- W4313360314 modified "2023-09-27" @default.
- W4313360314 title "Mutations in the 5′ NTR and the non-structural protein 3A of the coxsackievirus B3 selectively attenuate myocarditogenicity" @default.
- W4313360314 doi "https://doi.org/10.4049/jimmunol.196.supp.80.11" @default.
- W4313360314 hasPublicationYear "2016" @default.
- W4313360314 type Work @default.
- W4313360314 citedByCount "0" @default.
- W4313360314 crossrefType "journal-article" @default.
- W4313360314 hasAuthorship W4313360314A5001803460 @default.
- W4313360314 hasAuthorship W4313360314A5042986773 @default.
- W4313360314 hasAuthorship W4313360314A5047895999 @default.
- W4313360314 hasAuthorship W4313360314A5069866852 @default.
- W4313360314 hasAuthorship W4313360314A5071995530 @default.
- W4313360314 hasAuthorship W4313360314A5082677888 @default.
- W4313360314 hasAuthorship W4313360314A5089390018 @default.
- W4313360314 hasBestOaLocation W43133603142 @default.
- W4313360314 hasConcept C104317684 @default.
- W4313360314 hasConcept C140704245 @default.
- W4313360314 hasConcept C159047783 @default.
- W4313360314 hasConcept C164705383 @default.
- W4313360314 hasConcept C176944494 @default.
- W4313360314 hasConcept C2522874641 @default.
- W4313360314 hasConcept C2777888124 @default.
- W4313360314 hasConcept C2779120600 @default.
- W4313360314 hasConcept C2780875844 @default.
- W4313360314 hasConcept C501734568 @default.
- W4313360314 hasConcept C54355233 @default.
- W4313360314 hasConcept C60987743 @default.
- W4313360314 hasConcept C71924100 @default.
- W4313360314 hasConcept C81089528 @default.
- W4313360314 hasConcept C84148353 @default.
- W4313360314 hasConcept C86803240 @default.
- W4313360314 hasConceptScore W4313360314C104317684 @default.
- W4313360314 hasConceptScore W4313360314C140704245 @default.
- W4313360314 hasConceptScore W4313360314C159047783 @default.
- W4313360314 hasConceptScore W4313360314C164705383 @default.
- W4313360314 hasConceptScore W4313360314C176944494 @default.
- W4313360314 hasConceptScore W4313360314C2522874641 @default.
- W4313360314 hasConceptScore W4313360314C2777888124 @default.
- W4313360314 hasConceptScore W4313360314C2779120600 @default.
- W4313360314 hasConceptScore W4313360314C2780875844 @default.
- W4313360314 hasConceptScore W4313360314C501734568 @default.
- W4313360314 hasConceptScore W4313360314C54355233 @default.
- W4313360314 hasConceptScore W4313360314C60987743 @default.
- W4313360314 hasConceptScore W4313360314C71924100 @default.
- W4313360314 hasConceptScore W4313360314C81089528 @default.
- W4313360314 hasConceptScore W4313360314C84148353 @default.
- W4313360314 hasConceptScore W4313360314C86803240 @default.
- W4313360314 hasIssue "1_Supplement" @default.
- W4313360314 hasLocation W43133603141 @default.
- W4313360314 hasLocation W43133603142 @default.
- W4313360314 hasOpenAccess W4313360314 @default.
- W4313360314 hasPrimaryLocation W43133603141 @default.
- W4313360314 hasRelatedWork W1487857142 @default.
- W4313360314 hasRelatedWork W1881662972 @default.
- W4313360314 hasRelatedWork W1961203099 @default.
- W4313360314 hasRelatedWork W1972658748 @default.
- W4313360314 hasRelatedWork W2024956434 @default.
- W4313360314 hasRelatedWork W2086778880 @default.
- W4313360314 hasRelatedWork W2159527899 @default.
- W4313360314 hasRelatedWork W2349061742 @default.
- W4313360314 hasRelatedWork W2613621187 @default.
- W4313360314 hasRelatedWork W2998426862 @default.
- W4313360314 hasVolume "196" @default.
- W4313360314 isParatext "false" @default.
- W4313360314 isRetracted "false" @default.
- W4313360314 workType "article" @default.