Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313360323> ?p ?o ?g. }
Showing items 1 to 52 of
52
with 100 items per page.
- W4313360323 endingPage "62.14" @default.
- W4313360323 startingPage "62.14" @default.
- W4313360323 abstract "Abstract Foxp3+ regulatory T cells (Tregs) are critical to mantain intestinal homeostasis. Like all CD4+ T cells, Tregs require TCR-MHCII interactions for their development in thymus and differentiation in periphery. Past studies suggest that the TCR repertoire of intestinal lamina propria (siLP) Tregs is skewed towards food and commensal bacteria antigens. However, by using a transgenic mouse model that lacks peripheral MHCII expression and peripheral Tregs induction (K14 mice), we have demonstrated that thymically generated Tregs could enter to the siLP of weanlings and proliferate independently of MHCII to fill and maintain the compartment. Newly-generated Tregs egress from thymus as central Tregs and acquire an effector phenotype after TCR signals in periphery. However, despite the lack of MHCII in the siLP, K14 Tregs are activated and phenotypically similar to effector Tregs in WT siLP. Interestingly, transcriptional profiling reveals that many components of a TCR-dependent expression module are present in both K14 and WT siLP Tregs. Furthermore, differently to splenic Tregs, K14 siLP Tregs highly express Nur77 and IRF4, often regulated through TCR signaling. Tregs from K14 siLP localize mainly at isolated lymphoid follicles, where they are in proximity to B cells and dendritic cells; suggesting that siLP Tregs may still receive MHCII-independent signals from APCs, perhaps via costimulation molecules and/or paracrine cytokine stimulation. Indeed a short-term costimulation blockade with CTLA4-Ig reduces Nur77 expression on K14 siLP Tregs. Taken together, these results suggest that the intestinal microenvironment uniquely maintains the differentiation and homeostasis of effector Tregs independent of MHCII-TCR interactions." @default.
- W4313360323 created "2023-01-06" @default.
- W4313360323 creator A5042910738 @default.
- W4313360323 creator A5056599888 @default.
- W4313360323 date "2017-05-01" @default.
- W4313360323 modified "2023-09-23" @default.
- W4313360323 title "The intestinal lamina propria is a unique niche for regulatory T cells" @default.
- W4313360323 doi "https://doi.org/10.4049/jimmunol.198.supp.62.14" @default.
- W4313360323 hasPublicationYear "2017" @default.
- W4313360323 type Work @default.
- W4313360323 citedByCount "0" @default.
- W4313360323 crossrefType "journal-article" @default.
- W4313360323 hasAuthorship W4313360323A5042910738 @default.
- W4313360323 hasAuthorship W4313360323A5056599888 @default.
- W4313360323 hasConcept C185592680 @default.
- W4313360323 hasConcept C19317047 @default.
- W4313360323 hasConcept C203014093 @default.
- W4313360323 hasConcept C2776090121 @default.
- W4313360323 hasConcept C2779727006 @default.
- W4313360323 hasConcept C51785407 @default.
- W4313360323 hasConcept C86803240 @default.
- W4313360323 hasConcept C8891405 @default.
- W4313360323 hasConcept C95444343 @default.
- W4313360323 hasConceptScore W4313360323C185592680 @default.
- W4313360323 hasConceptScore W4313360323C19317047 @default.
- W4313360323 hasConceptScore W4313360323C203014093 @default.
- W4313360323 hasConceptScore W4313360323C2776090121 @default.
- W4313360323 hasConceptScore W4313360323C2779727006 @default.
- W4313360323 hasConceptScore W4313360323C51785407 @default.
- W4313360323 hasConceptScore W4313360323C86803240 @default.
- W4313360323 hasConceptScore W4313360323C8891405 @default.
- W4313360323 hasConceptScore W4313360323C95444343 @default.
- W4313360323 hasIssue "1_Supplement" @default.
- W4313360323 hasLocation W43133603231 @default.
- W4313360323 hasOpenAccess W4313360323 @default.
- W4313360323 hasPrimaryLocation W43133603231 @default.
- W4313360323 hasRelatedWork W1583700542 @default.
- W4313360323 hasRelatedWork W1973523687 @default.
- W4313360323 hasRelatedWork W2131745573 @default.
- W4313360323 hasRelatedWork W2519743187 @default.
- W4313360323 hasRelatedWork W2592570385 @default.
- W4313360323 hasRelatedWork W2593426839 @default.
- W4313360323 hasRelatedWork W2755256798 @default.
- W4313360323 hasRelatedWork W3108702947 @default.
- W4313360323 hasRelatedWork W3147849036 @default.
- W4313360323 hasRelatedWork W4290034612 @default.
- W4313360323 hasVolume "198" @default.
- W4313360323 isParatext "false" @default.
- W4313360323 isRetracted "false" @default.
- W4313360323 workType "article" @default.