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- W4313360374 abstract "Summary By various methods, some of which have been previously described, it is possible to extract from meningococci of the four agglutination groups a substance or substances highly toxic for mice and rabbits. Evidence is presented which seems to prove that the toxin is an endotoxin. A method is described for preparing uniform and stable lots of meningococcus endotoxin, upon which definite m.l.d. determinations can be made. The precipitation and removal of cellular protein by means of acetic acid from sodium hydroxide extracts of meningococci appears to be an important step in the method. This toxin is a tissue poison, has a dilating effect on the blood vessels and produces hemorrhage in the brain. The Shwartzman phenomenon may be reproduced by the endotoxin. Some rabbits may be made tolerant or possibly immune to the local and systemic effects of the toxin. The endotoxin may be neutralized by some lots of specific immune horse and rabbit serum. The study is being continued." @default.
- W4313360374 created "2023-01-06" @default.
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- W4313360374 date "1932-10-01" @default.
- W4313360374 modified "2023-09-27" @default.
- W4313360374 title "Studies on Meningococcus" @default.
- W4313360374 doi "https://doi.org/10.4049/jimmunol.23.4.291" @default.
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