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• W4313360788 startingPage "643" @default.
• W4313360788 abstract "Renal cell carcinoma is one of the common cancers whose incidence and mortality are continuously growing worldwide. Initially, this type of tumour is usually asymptomatic. Due to the lack of reliable diagnostic markers, one-third of ccRCC patients already have distant metastases at the time of diagnosis. This underlines the importance of establishing biomarkers that would enable the prediction of the disease’s course and the risk of metastasis. LncRNA, which modulates genes at the epigenetic, transcriptional, and post-transcriptional levels, appears promising. The actions of lncRNA involve sponging and sequestering target miRNAs, thus affecting numerous biological processes. Studies have confirmed the involvement of RNAs in various diseases, including RCC. In this review, we focused on MALAT1 (a marker of serious pathological changes and a factor in the promotion of tumorigenesis), RCAT1 (tumour promoter in RCC), DUXAP9 (a plausible marker of localized ccRCC), TCL6 (exerting tumour-suppressive effects in renal cancer), LINC00342 (acting as an oncogene), AGAP2 Antisense1 (plausible predictor of RCC progression), DLEU2 (factor promoting tumours growth via the regulation of epithelial-mesenchymal transition), NNT-AS1 (sponge of miR-22 contributing to tumour progression), LINC00460 (favouring ccRCC development and progression) and Lnc-LSG1 (a factor that may stimulate ccRCC metastasis)." @default.
• W4313360788 created "2023-01-06" @default.
• W4313360788 creator A5037767798 @default.
• W4313360788 creator A5044324027 @default.
• W4313360788 creator A5055736019 @default.
• W4313360788 creator A5080925704 @default.
• W4313360788 creator A5083390325 @default.
• W4313360788 date "2022-12-30" @default.
• W4313360788 modified "2023-09-26" @default.
• W4313360788 title "The Role of Long Noncoding RNA (lncRNAs) Biomarkers in Renal Cell Carcinoma" @default.
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