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- W4313360893 abstract "Overall, results from this study support an important role for Runx3 in the regulation of the immune 74 response to IAV with, intriguingly, very limited effects in protection. One explanation, as speculated 75 by the authors, is that there might be compensating effects from different arms of the immune system, 76i.e. changes in the numbers of lung myeloid cells might compensate for loss of antigen-specific CD8+ 77 T cells. An open question is how the loss of CD8+ T cells by Runx3 depletion would affect protection 78 against a secondary IAV infection, which might provide evidence for a role for Runx3 in protection 79 through adaptive immunity. 80 81The manuscripts in this Research Topic present exciting findings and insights to expand our 83 understanding of the molecular basis of immune responses induced upon IAV infection. This 84 information helps us clarify key aspects related with viral-host interactions and the mechanism of 85 action of host effector molecules and cells involved in defense machineries. 86" @default.
- W4313360893 created "2023-01-06" @default.
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- W4313360893 date "2022-12-30" @default.
- W4313360893 modified "2023-09-26" @default.
- W4313360893 title "Editorial: Updates on immunity to influenza A virus in humans and animals" @default.
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- W4313360893 doi "https://doi.org/10.3389/fimmu.2022.1115406" @default.
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