Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313361247> ?p ?o ?g. }
- W4313361247 endingPage "598" @default.
- W4313361247 startingPage "598" @default.
- W4313361247 abstract "Potassium-dependent sodium-calcium exchangers (NCKX) have emerged as key determinants of calcium (Ca2+) signaling and homeostasis, especially in environments where ion concentrations undergo large changes, such as excitatory cells and transport epithelia. The regulation of NCKX transporters enables them to respond to the changing cellular environment thereby helping to shape the extent and kinetics of Ca2+ signals. This review examines the current knowledge of the different ways in which NCKX activity can be modulated. These include (i) cellular and dynamic subcellular location (ii); changes in protein expression mediated at the gene, transcript, or protein level (iii); genetic changes resulting in altered protein structure or expression (iv); regulation via changes in substrate concentration (v); and post-translational modification, partner protein interactions, and allosteric regulation. Detailed mechanistic understanding of NCKX regulation is an emerging area of research with the potential to provide important new insights into transporter function, the control of Ca2+ signals, and possible interventions for dysregulated Ca2+ homeostasis." @default.
- W4313361247 created "2023-01-06" @default.
- W4313361247 creator A5000940482 @default.
- W4313361247 creator A5062560228 @default.
- W4313361247 date "2022-12-29" @default.
- W4313361247 modified "2023-10-14" @default.
- W4313361247 title "Regulation of K+-Dependent Na+/Ca2+-Exchangers (NCKX)" @default.
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