Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313361336> ?p ?o ?g. }
- W4313361336 endingPage "633" @default.
- W4313361336 startingPage "633" @default.
- W4313361336 abstract "DNA methylation represents a crucial mechanism of epigenetic regulation in hematologic malignancies. The methylation process is controlled by specific DNA methyl transferases and other regulators, which are often affected by genetic alterations. Global hypomethylation and hypermethylation of tumor suppressor genes are associated with hematologic cancer development and progression. Several epi-drugs have been successfully implicated in the treatment of hematologic malignancies, including the hypomethylating agents (HMAs) decitabine and azacytidine. However, combinations with other treatment modalities and the discovery of new molecules are still the subject of research to increase sensitivity to anti-cancer therapies and improve patient outcomes. In this review, we summarized the main functions of DNA methylation regulators and genetic events leading to changes in methylation landscapes. We provide current knowledge about target genes with aberrant methylation levels in leukemias, myelodysplastic syndromes, and malignant lymphomas. Moreover, we provide an overview of the clinical trials, focused mainly on the combined therapy of HMAs with other treatments and its impact on adverse events, treatment efficacy, and survival rates among hematologic cancer patients. In the era of precision medicine, a transition from genes to their regulation opens up the possibility of an epigenetic-based approach as a diagnostic, prognostic, and therapeutic tool." @default.
- W4313361336 created "2023-01-06" @default.
- W4313361336 creator A5017758626 @default.
- W4313361336 creator A5031309175 @default.
- W4313361336 creator A5052989773 @default.
- W4313361336 creator A5072708963 @default.
- W4313361336 creator A5085950307 @default.
- W4313361336 date "2022-12-30" @default.
- W4313361336 modified "2023-09-30" @default.
- W4313361336 title "Targeting DNA Methylation in Leukemia, Myelodysplastic Syndrome, and Lymphoma: A Potential Diagnostic, Prognostic, and Therapeutic Tool" @default.
- W4313361336 cites W1600365609 @default.
- W4313361336 cites W1620346911 @default.
- W4313361336 cites W1891612065 @default.
- W4313361336 cites W1960205255 @default.
- W4313361336 cites W1966324832 @default.
- W4313361336 cites W1968975746 @default.
- W4313361336 cites W1972647537 @default.
- W4313361336 cites W1978449568 @default.
- W4313361336 cites W1980947373 @default.
- W4313361336 cites W1981110830 @default.
- W4313361336 cites W1986228316 @default.
- W4313361336 cites W1992703511 @default.
- W4313361336 cites W1992952077 @default.
- W4313361336 cites W1995612816 @default.
- W4313361336 cites W1996834122 @default.
- W4313361336 cites W2002934318 @default.
- W4313361336 cites W2009543045 @default.
- W4313361336 cites W2010318973 @default.
- W4313361336 cites W2011843149 @default.
- W4313361336 cites W2012860082 @default.
- W4313361336 cites W2013398587 @default.
- W4313361336 cites W2016025537 @default.
- W4313361336 cites W2017735587 @default.
- W4313361336 cites W2022533018 @default.
- W4313361336 cites W2024384466 @default.
- W4313361336 cites W2025252700 @default.
- W4313361336 cites W2029459160 @default.
- W4313361336 cites W2030352564 @default.
- W4313361336 cites W2035634736 @default.
- W4313361336 cites W2041073422 @default.
- W4313361336 cites W2041191257 @default.
- W4313361336 cites W2041690843 @default.
- W4313361336 cites W2048034141 @default.
- W4313361336 cites W2052631853 @default.
- W4313361336 cites W2054111192 @default.
- W4313361336 cites W2058362059 @default.
- W4313361336 cites W2059981122 @default.
- W4313361336 cites W2062461447 @default.
- W4313361336 cites W2078972833 @default.
- W4313361336 cites W2094506273 @default.
- W4313361336 cites W2097459133 @default.
- W4313361336 cites W2100637470 @default.
- W4313361336 cites W2104537787 @default.
- W4313361336 cites W2105273554 @default.
- W4313361336 cites W2105528893 @default.
- W4313361336 cites W2115707319 @default.
- W4313361336 cites W2116496791 @default.
- W4313361336 cites W2116599482 @default.
- W4313361336 cites W2119117682 @default.
- W4313361336 cites W2130907138 @default.
- W4313361336 cites W2131072337 @default.
- W4313361336 cites W2131377078 @default.
- W4313361336 cites W2140929811 @default.
- W4313361336 cites W2142682046 @default.
- W4313361336 cites W2143505663 @default.
- W4313361336 cites W2145338511 @default.
- W4313361336 cites W2145993043 @default.
- W4313361336 cites W2150293957 @default.
- W4313361336 cites W2150958832 @default.
- W4313361336 cites W2159255547 @default.
- W4313361336 cites W2160254770 @default.
- W4313361336 cites W2171201670 @default.
- W4313361336 cites W2186118481 @default.
- W4313361336 cites W2237741020 @default.
- W4313361336 cites W2280983302 @default.
- W4313361336 cites W2285872418 @default.
- W4313361336 cites W2341894622 @default.
- W4313361336 cites W2394559893 @default.
- W4313361336 cites W2401586223 @default.
- W4313361336 cites W2410091884 @default.
- W4313361336 cites W2465579482 @default.
- W4313361336 cites W2514915762 @default.
- W4313361336 cites W2523422043 @default.
- W4313361336 cites W2549518011 @default.
- W4313361336 cites W2562022240 @default.
- W4313361336 cites W2570769902 @default.
- W4313361336 cites W2587989857 @default.
- W4313361336 cites W2591048449 @default.
- W4313361336 cites W2592035771 @default.
- W4313361336 cites W2601444497 @default.
- W4313361336 cites W2605700912 @default.
- W4313361336 cites W2618708490 @default.
- W4313361336 cites W2737544727 @default.
- W4313361336 cites W2743932745 @default.
- W4313361336 cites W2753775033 @default.
- W4313361336 cites W2754437410 @default.
- W4313361336 cites W2758263899 @default.
- W4313361336 cites W2769907060 @default.