Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313361430> ?p ?o ?g. }
- W4313361430 endingPage "155" @default.
- W4313361430 startingPage "155" @default.
- W4313361430 abstract "Posttraumatic headache (PTH) attributed to traumatic brain injury (TBI) is a secondary headache developed within 7 days after head injury, and in a substantial number of patients PTH becomes chronic and lasts for more than 3 months. Current medications are almost entirely relied on the treatment of primary headache such as migraine, due to its migraine-like phenotype and the limited understanding on the PTH pathogenic mechanisms. To this end, increasing preclinical studies have been conducted in the last decade. We focus in this review on the trigeminovascular system from the animal studies since it provides the primary nociceptive sensory afferents innervating the head and face region, and the pathological changes in the trigeminal pathway are thought to play a key role in the development of PTH. In addition to the pathologies, PTH-like behaviors induced by TBI and further exacerbated by nitroglycerin, a general headache inducer through vasodilation are reviewed. We will overview the current pharmacotherapies including calcitonin gene-related peptide (CGRP) monoclonal antibody and sumatriptan in the PTH animal models. Given that modulation of the endocannabinoid (eCB) system has been well-documented in the treatment of migraine and TBI, the therapeutic potential of eCB in PTH will also be discussed." @default.
- W4313361430 created "2023-01-06" @default.
- W4313361430 creator A5055529169 @default.
- W4313361430 creator A5065754575 @default.
- W4313361430 date "2022-12-30" @default.
- W4313361430 modified "2023-09-25" @default.
- W4313361430 title "Preclinical Studies of Posttraumatic Headache and the Potential Therapeutics" @default.
- W4313361430 cites W1506884824 @default.
- W4313361430 cites W1568755291 @default.
- W4313361430 cites W1645449597 @default.
- W4313361430 cites W1683401737 @default.
- W4313361430 cites W1691566859 @default.
- W4313361430 cites W1886084954 @default.
- W4313361430 cites W1963842138 @default.
- W4313361430 cites W1970860218 @default.
- W4313361430 cites W1972907910 @default.
- W4313361430 cites W1974360350 @default.
- W4313361430 cites W1974515050 @default.
- W4313361430 cites W1975016302 @default.
- W4313361430 cites W1976505981 @default.
- W4313361430 cites W1978186585 @default.
- W4313361430 cites W1979009614 @default.
- W4313361430 cites W1982946237 @default.
- W4313361430 cites W1986309326 @default.
- W4313361430 cites W1991879618 @default.
- W4313361430 cites W199598560 @default.
- W4313361430 cites W1996614758 @default.
- W4313361430 cites W1998472195 @default.
- W4313361430 cites W2001268685 @default.
- W4313361430 cites W2009864778 @default.
- W4313361430 cites W2010043377 @default.
- W4313361430 cites W2014359029 @default.
- W4313361430 cites W2016327412 @default.
- W4313361430 cites W2020844842 @default.
- W4313361430 cites W2026793904 @default.
- W4313361430 cites W2030864168 @default.
- W4313361430 cites W2032715817 @default.
- W4313361430 cites W2035348749 @default.
- W4313361430 cites W2037435313 @default.
- W4313361430 cites W2040792219 @default.
- W4313361430 cites W2041155782 @default.
- W4313361430 cites W2043115881 @default.
- W4313361430 cites W2046951924 @default.
- W4313361430 cites W2047408156 @default.
- W4313361430 cites W2051600991 @default.
- W4313361430 cites W2055797258 @default.
- W4313361430 cites W2056197197 @default.
- W4313361430 cites W2057126072 @default.
- W4313361430 cites W2057621671 @default.
- W4313361430 cites W2061476401 @default.
- W4313361430 cites W2062997220 @default.
- W4313361430 cites W2069693356 @default.
- W4313361430 cites W2072056062 @default.
- W4313361430 cites W2074601245 @default.
- W4313361430 cites W2078028780 @default.
- W4313361430 cites W2079972851 @default.
- W4313361430 cites W2082358684 @default.
- W4313361430 cites W2084872420 @default.
- W4313361430 cites W2086557733 @default.
- W4313361430 cites W2086696719 @default.
- W4313361430 cites W2089240440 @default.
- W4313361430 cites W2091025118 @default.
- W4313361430 cites W2093129801 @default.
- W4313361430 cites W2103044571 @default.
- W4313361430 cites W2103351070 @default.
- W4313361430 cites W2107296905 @default.
- W4313361430 cites W2109070839 @default.
- W4313361430 cites W2110352413 @default.
- W4313361430 cites W2115351521 @default.
- W4313361430 cites W2115558652 @default.
- W4313361430 cites W2116030730 @default.
- W4313361430 cites W2120905598 @default.
- W4313361430 cites W2121286559 @default.
- W4313361430 cites W2122818778 @default.
- W4313361430 cites W2123562126 @default.
- W4313361430 cites W2124814689 @default.
- W4313361430 cites W2128549678 @default.
- W4313361430 cites W2130435998 @default.
- W4313361430 cites W2131924308 @default.
- W4313361430 cites W2138814983 @default.
- W4313361430 cites W2143970752 @default.
- W4313361430 cites W2149931140 @default.
- W4313361430 cites W2153751480 @default.
- W4313361430 cites W2156503648 @default.
- W4313361430 cites W2157477398 @default.
- W4313361430 cites W2157647994 @default.
- W4313361430 cites W2158389474 @default.
- W4313361430 cites W2162660365 @default.
- W4313361430 cites W2163386604 @default.
- W4313361430 cites W2166206304 @default.
- W4313361430 cites W2168098463 @default.
- W4313361430 cites W2169980429 @default.
- W4313361430 cites W2172201406 @default.
- W4313361430 cites W2258161409 @default.
- W4313361430 cites W2299431741 @default.
- W4313361430 cites W2321316620 @default.
- W4313361430 cites W2336840495 @default.
- W4313361430 cites W2346282463 @default.