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- W4313361650 endingPage "186" @default.
- W4313361650 startingPage "170" @default.
- W4313361650 abstract "Metabolic zonation in the liver carries out the maintenance of organ and body homeostasis. Hypoxia is an inherent physiological feature of the liver and contributes to the zonal properties of the hepatic parenchyma. As a master regulator of hypoxia, the transcription factor hypoxia-inducing factor (HIF) is stabilized primarily by oxygen availability, and it is thought to contribute to steatohepatitis due to alcohol-related (ASH) and non-alcohol-related liver disease (NASH). Cholesterol has emerged as an important player in both diseases, and hypoxia increases hepatic cholesterol levels. Steroidogenic acute regulatory protein 1 (STARD1) is a mitochondrial outer membrane protein that transfers cholesterol to mitochondrial inner membrane for metabolic processing and acts as the rate-limiting step in the alternative pathway of bile acid synthesis in hepatocytes. STARD1 expression increases in ASH and NASH and determines the accumulation of cholesterol in mitochondria, which impacts the physico-chemical mitochondrial membranes properties and as a consequence impairs the activity of specific mitochondrial solute carriers, such as the 2-oxoglutarate carrier (2-OGC), limiting the exchange between cytosolic glutathione and mitochondrial 2-oxoglutarate (2-OG). Although HIF-1 is stabilized in hypoxia largely due to the requirement of prolylhydroxylases (PHDs) for oxygen to signal HIF degradation, PHDs are also dependent on 2-OG, and therefore it is conceivable that impairment of 2-OGC by STARD1-mediated cholesterol accumulation may contribute to HIF-1 stabilization due in part to decreased availability of cytosolic 2-OG. In this perspective, this review explores the interplay between HIF-1 stabilization and STARD1 induction and the potential contribution of this functional relationship to ASH and NASH." @default.
- W4313361650 created "2023-01-06" @default.
- W4313361650 creator A5045735942 @default.
- W4313361650 creator A5058717462 @default.
- W4313361650 creator A5080875810 @default.
- W4313361650 date "2022-12-30" @default.
- W4313361650 modified "2023-10-18" @default.
- W4313361650 title "Hypoxia signaling and cholesterol/steroidogenic acute regulatory protein 1 axis: interplay and role in alcohol and non-alcohol-related liver diseases" @default.
- W4313361650 cites W1549576586 @default.
- W4313361650 cites W1592609177 @default.
- W4313361650 cites W1609496572 @default.
- W4313361650 cites W1616047414 @default.
- W4313361650 cites W1965827991 @default.
- W4313361650 cites W1969024223 @default.
- W4313361650 cites W1970541648 @default.
- W4313361650 cites W1977162268 @default.
- W4313361650 cites W1979087898 @default.
- W4313361650 cites W1981577099 @default.
- W4313361650 cites W1985434991 @default.
- W4313361650 cites W1990259136 @default.
- W4313361650 cites W1995445966 @default.
- W4313361650 cites W1995519633 @default.
- W4313361650 cites W1996228271 @default.
- W4313361650 cites W2010101404 @default.
- W4313361650 cites W2011810742 @default.
- W4313361650 cites W2013112669 @default.
- W4313361650 cites W2013818100 @default.
- W4313361650 cites W2016057875 @default.
- W4313361650 cites W2016496152 @default.
- W4313361650 cites W2018504915 @default.
- W4313361650 cites W2026189820 @default.
- W4313361650 cites W2032169621 @default.
- W4313361650 cites W2035855731 @default.
- W4313361650 cites W2037132483 @default.
- W4313361650 cites W2038449972 @default.
- W4313361650 cites W2039490460 @default.
- W4313361650 cites W2039559614 @default.
- W4313361650 cites W2039775393 @default.
- W4313361650 cites W2041570796 @default.
- W4313361650 cites W2050830271 @default.
- W4313361650 cites W2051215275 @default.
- W4313361650 cites W2052234975 @default.
- W4313361650 cites W2057227267 @default.
- W4313361650 cites W2059775894 @default.
- W4313361650 cites W2070053386 @default.
- W4313361650 cites W2071047616 @default.
- W4313361650 cites W2075880922 @default.
- W4313361650 cites W2076869762 @default.
- W4313361650 cites W2082011949 @default.
- W4313361650 cites W2083528019 @default.
- W4313361650 cites W2087214757 @default.
- W4313361650 cites W2087408461 @default.
- W4313361650 cites W2090786698 @default.
- W4313361650 cites W2092621535 @default.
- W4313361650 cites W2093602965 @default.
- W4313361650 cites W2094575179 @default.
- W4313361650 cites W2095296616 @default.
- W4313361650 cites W2095935706 @default.
- W4313361650 cites W2096388785 @default.
- W4313361650 cites W2102434679 @default.
- W4313361650 cites W2105913337 @default.
- W4313361650 cites W2114152651 @default.
- W4313361650 cites W2117568170 @default.
- W4313361650 cites W2120345534 @default.
- W4313361650 cites W2125415514 @default.
- W4313361650 cites W2126842666 @default.
- W4313361650 cites W2139387872 @default.
- W4313361650 cites W2141221893 @default.
- W4313361650 cites W2147322409 @default.
- W4313361650 cites W2153687754 @default.
- W4313361650 cites W2157369531 @default.
- W4313361650 cites W2163069245 @default.
- W4313361650 cites W2163293935 @default.
- W4313361650 cites W2164901739 @default.
- W4313361650 cites W2165623186 @default.
- W4313361650 cites W2165855078 @default.
- W4313361650 cites W2171230374 @default.
- W4313361650 cites W2232338922 @default.
- W4313361650 cites W2340727889 @default.
- W4313361650 cites W2416352929 @default.
- W4313361650 cites W2497208646 @default.
- W4313361650 cites W2510979152 @default.
- W4313361650 cites W2546328780 @default.
- W4313361650 cites W2555920391 @default.
- W4313361650 cites W2558943511 @default.
- W4313361650 cites W2564454911 @default.
- W4313361650 cites W2575236525 @default.
- W4313361650 cites W2580212801 @default.
- W4313361650 cites W2594059806 @default.
- W4313361650 cites W2629129934 @default.
- W4313361650 cites W2755156586 @default.
- W4313361650 cites W2755389887 @default.
- W4313361650 cites W2791626659 @default.
- W4313361650 cites W2805074542 @default.
- W4313361650 cites W2805890278 @default.
- W4313361650 cites W2890333539 @default.
- W4313361650 cites W2899457119 @default.
- W4313361650 cites W2909906311 @default.