FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313361958> ?p ?o ?g. }

• W4313361958 endingPage "621" @default.
• W4313361958 startingPage "621" @default.
• W4313361958 abstract "Activating transcription factor 4 (ATF4) is involved in muscle atrophy through the overexpression of some atrogenes. However, it also controls the transcription of genes involved in muscle homeostasis maintenance. Here, we explored the effect of ATF4 activation by the pharmacological molecule halofuginone during hindlimb suspension (HS)-induced muscle atrophy. Firstly, we reported that periodic activation of ATF4-regulated atrogenes (Gadd45a, Cdkn1a, and Eif4ebp1) by halofuginone was not associated with muscle atrophy in healthy mice. Secondly, halofuginone-treated mice even showed reduced atrophy during HS, although the induction of the ATF4 pathway was identical to that in untreated HS mice. We further showed that halofuginone inhibited transforming growth factor-β (TGF-β) signalling, while promoting bone morphogenetic protein (BMP) signalling in healthy mice and slightly preserved protein synthesis during HS. Finally, ATF4-regulated atrogenes were also induced in the atrophy-resistant muscles of hibernating brown bears, in which we previously also reported concurrent TGF-β inhibition and BMP activation. Overall, we show that ATF4-induced atrogenes can be uncoupled from muscle atrophy. In addition, our data also indicate that halofuginone can control the TGF-β/BMP balance towards muscle mass maintenance. Whether halofuginone-induced BMP signalling can counteract the effect of ATF4-induced atrogenes needs to be further investigated and may open a new avenue to fight muscle atrophy. Finally, our study opens the way for further studies to identify well-tolerated chemical compounds in humans that are able to fine-tune the TGF-β/BMP balance and could be used to preserve muscle mass during catabolic situations." @default.
• W4313361958 created "2023-01-06" @default.
• W4313361958 creator A5005468664 @default.
• W4313361958 creator A5007982020 @default.
• W4313361958 creator A5008772167 @default.
• W4313361958 creator A5008947766 @default.
• W4313361958 creator A5029172736 @default.
• W4313361958 creator A5030713646 @default.
• W4313361958 creator A5042087350 @default.
• W4313361958 creator A5048111507 @default.
• W4313361958 creator A5058851443 @default.
• W4313361958 creator A5060648910 @default.
• W4313361958 creator A5062355338 @default.
• W4313361958 creator A5071744340 @default.
• W4313361958 creator A5075195429 @default.
• W4313361958 creator A5086308507 @default.
• W4313361958 creator A5088711188 @default.
• W4313361958 creator A5088819479 @default.
• W4313361958 creator A5089572478 @default.
• W4313361958 creator A5091364916 @default.
• W4313361958 creator A5091648691 @default.
• W4313361958 date "2022-12-30" @default.
• W4313361958 modified "2023-10-09" @default.
• W4313361958 title "Induction of ATF4-Regulated Atrogenes Is Uncoupled from Muscle Atrophy during Disuse in Halofuginone-Treated Mice and in Hibernating Brown Bears" @default.
• W4313361958 cites W1603706308 @default.
• W4313361958 cites W1813667843 @default.
• W4313361958 cites W1965629756 @default.
• W4313361958 cites W1995565902 @default.
• W4313361958 cites W1997014674 @default.
• W4313361958 cites W1997581921 @default.
• W4313361958 cites W2003162584 @default.
• W4313361958 cites W2005109257 @default.
• W4313361958 cites W2007598683 @default.
• W4313361958 cites W2008062030 @default.
• W4313361958 cites W2009641783 @default.
• W4313361958 cites W2014899456 @default.
• W4313361958 cites W2014905930 @default.
• W4313361958 cites W2016772121 @default.
• W4313361958 cites W2025139842 @default.
• W4313361958 cites W2026386550 @default.
• W4313361958 cites W2033924360 @default.
• W4313361958 cites W2035555824 @default.
• W4313361958 cites W2036787961 @default.
• W4313361958 cites W2047259732 @default.
• W4313361958 cites W2047284298 @default.
• W4313361958 cites W2048098925 @default.
• W4313361958 cites W2050906087 @default.
• W4313361958 cites W2052792097 @default.
• W4313361958 cites W2059083151 @default.
• W4313361958 cites W2067581129 @default.
• W4313361958 cites W2072152524 @default.
• W4313361958 cites W2073704223 @default.
• W4313361958 cites W2076031762 @default.
• W4313361958 cites W2091641544 @default.
• W4313361958 cites W2093021904 @default.
• W4313361958 cites W2107979620 @default.
• W4313361958 cites W2110508238 @default.
• W4313361958 cites W2120928128 @default.
• W4313361958 cites W2131632095 @default.
• W4313361958 cites W2141543467 @default.
• W4313361958 cites W2154083884 @default.
• W4313361958 cites W2154241781 @default.
• W4313361958 cites W2167512318 @default.
• W4313361958 cites W2171071516 @default.
• W4313361958 cites W2174949391 @default.
• W4313361958 cites W2319582286 @default.
• W4313361958 cites W2387883865 @default.
• W4313361958 cites W2400936627 @default.
• W4313361958 cites W2431575019 @default.
• W4313361958 cites W2481611869 @default.
• W4313361958 cites W2518959324 @default.
• W4313361958 cites W2594788856 @default.
• W4313361958 cites W2627003412 @default.
• W4313361958 cites W2761992725 @default.
• W4313361958 cites W2803868325 @default.
• W4313361958 cites W2889742267 @default.
• W4313361958 cites W2901573887 @default.
• W4313361958 cites W2913090449 @default.
• W4313361958 cites W2935622333 @default.
• W4313361958 cites W2961607565 @default.
• W4313361958 cites W2999803737 @default.
• W4313361958 cites W3006951656 @default.
• W4313361958 cites W3015626306 @default.
• W4313361958 cites W3030244042 @default.
• W4313361958 cites W3040242669 @default.
• W4313361958 cites W3083009715 @default.
• W4313361958 cites W3113128734 @default.
• W4313361958 cites W3120576545 @default.
• W4313361958 cites W3133761944 @default.
• W4313361958 cites W3163820360 @default.
• W4313361958 cites W3174165743 @default.
• W4313361958 cites W3174382057 @default.
• W4313361958 cites W3184013170 @default.
• W4313361958 cites W3185119031 @default.
• W4313361958 cites W3192947947 @default.
• W4313361958 cites W38128938 @default.
• W4313361958 cites W4200521246 @default.
• W4313361958 cites W4220872250 @default.

• next