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- W4313362044 abstract "Periodontitis is a non-communicable chronic inflammatory disease characterized by the progressive and irreversible breakdown of the soft periodontal tissues and resorption of teeth-supporting alveolar bone. The etiology of periodontitis involves dysbiotic shifts in the diversity of microbial communities inhabiting the subgingival crevice, which is dominated by anaerobic Gram-negative bacteria, including Porphyromonas gingivalis. Indeed, P. gingivalis is a keystone pathogen with a repertoire of attributes that allow it to colonize periodontal tissues and influence the metabolism, growth rate, and virulence of other periodontal bacteria. The pathogenic potential of P. gingivalis has been traditionally analyzed using classical biochemical and molecular approaches. However, the arrival of new techniques, such as whole-genome sequencing, metagenomics, metatranscriptomics, proteomics, and metabolomics, allowed the generation of high-throughput data, offering a suitable option for bacterial analysis, allowing a deeper understanding of the pathogenic properties of P. gingivalis and its interaction with the host. In the present review, we revise the use of the different -omics technologies and techniques used to analyze bacteria and discuss their potential in studying the pathogenic potential of P. gingivalis." @default.
- W4313362044 created "2023-01-06" @default.
- W4313362044 creator A5030768974 @default.
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- W4313362044 date "2022-12-30" @default.
- W4313362044 modified "2023-10-10" @default.
- W4313362044 title "Contribution of −Omics Technologies in the Study of Porphyromonas gingivalis during Periodontitis Pathogenesis: A Minireview" @default.
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- W4313362044 doi "https://doi.org/10.3390/ijms24010620" @default.
- W4313362044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36614064" @default.
- W4313362044 hasPublicationYear "2022" @default.
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