Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313362072> ?p ?o ?g. }
- W4313362072 endingPage "215" @default.
- W4313362072 startingPage "215" @default.
- W4313362072 abstract "The three-dimensional architecture of genomes is complex. It is organized as fibers, loops, and domains that form high-order structures. By using different chromosome conformation techniques, the complex relationship between transcription and genome organization in the three-dimensional organization of genomes has been deciphered. Epigenetic changes, such as DNA methylation and histone modification, are the hallmark of cancers. Tumor initiation, progression, and metastasis are linked to these epigenetic modifications. Epigenetic inhibitors can reverse these altered modifications. A number of epigenetic inhibitors have been approved by FDA that target DNA methylation and histone modification. This review discusses the techniques involved in studying the three-dimensional organization of genomes, DNA methylation and histone modification, epigenetic deregulation in cancer, and epigenetic therapies targeting the tumor." @default.
- W4313362072 created "2023-01-06" @default.
- W4313362072 creator A5009877131 @default.
- W4313362072 creator A5054598528 @default.
- W4313362072 date "2022-12-29" @default.
- W4313362072 modified "2023-10-14" @default.
- W4313362072 title "Epimutations and Their Effect on Chromatin Organization: Exciting Avenues for Cancer Treatment" @default.
- W4313362072 cites W1506343731 @default.
- W4313362072 cites W1511815964 @default.
- W4313362072 cites W1605145036 @default.
- W4313362072 cites W1660678623 @default.
- W4313362072 cites W1917736788 @default.
- W4313362072 cites W1921071413 @default.
- W4313362072 cites W1963995106 @default.
- W4313362072 cites W1969691479 @default.
- W4313362072 cites W1974223852 @default.
- W4313362072 cites W1976033223 @default.
- W4313362072 cites W1977304678 @default.
- W4313362072 cites W1981452104 @default.
- W4313362072 cites W1982356313 @default.
- W4313362072 cites W1989476631 @default.
- W4313362072 cites W1990756176 @default.
- W4313362072 cites W1991149014 @default.
- W4313362072 cites W1993627126 @default.
- W4313362072 cites W1996567457 @default.
- W4313362072 cites W1997029250 @default.
- W4313362072 cites W1997981312 @default.
- W4313362072 cites W2004380688 @default.
- W4313362072 cites W2005629927 @default.
- W4313362072 cites W2005829971 @default.
- W4313362072 cites W2009576540 @default.
- W4313362072 cites W2009858080 @default.
- W4313362072 cites W2010297690 @default.
- W4313362072 cites W2010429928 @default.
- W4313362072 cites W2010437331 @default.
- W4313362072 cites W2011317343 @default.
- W4313362072 cites W2013799496 @default.
- W4313362072 cites W2017492512 @default.
- W4313362072 cites W2018508414 @default.
- W4313362072 cites W2020031294 @default.
- W4313362072 cites W2020459598 @default.
- W4313362072 cites W2020500691 @default.
- W4313362072 cites W2020977773 @default.
- W4313362072 cites W2021710587 @default.
- W4313362072 cites W2029457245 @default.
- W4313362072 cites W2031197086 @default.
- W4313362072 cites W2032271983 @default.
- W4313362072 cites W2033027341 @default.
- W4313362072 cites W2033247628 @default.
- W4313362072 cites W2034340491 @default.
- W4313362072 cites W2036777838 @default.
- W4313362072 cites W2039068825 @default.
- W4313362072 cites W2041686632 @default.
- W4313362072 cites W2041844803 @default.
- W4313362072 cites W2041993671 @default.
- W4313362072 cites W2042080470 @default.
- W4313362072 cites W2042233932 @default.
- W4313362072 cites W2043794217 @default.
- W4313362072 cites W2045450732 @default.
- W4313362072 cites W2048002474 @default.
- W4313362072 cites W2048523500 @default.
- W4313362072 cites W2049216034 @default.
- W4313362072 cites W2054085969 @default.
- W4313362072 cites W2054301876 @default.
- W4313362072 cites W2060446375 @default.
- W4313362072 cites W2063296278 @default.
- W4313362072 cites W2064442490 @default.
- W4313362072 cites W2068289512 @default.
- W4313362072 cites W2068473772 @default.
- W4313362072 cites W2070991372 @default.
- W4313362072 cites W2073026107 @default.
- W4313362072 cites W2075463378 @default.
- W4313362072 cites W2078211225 @default.
- W4313362072 cites W2080029028 @default.
- W4313362072 cites W2081279521 @default.
- W4313362072 cites W2083959000 @default.
- W4313362072 cites W2084295010 @default.
- W4313362072 cites W2084885369 @default.
- W4313362072 cites W2084908485 @default.
- W4313362072 cites W2087507084 @default.
- W4313362072 cites W2089894746 @default.
- W4313362072 cites W2090037139 @default.
- W4313362072 cites W2093664191 @default.
- W4313362072 cites W2095026025 @default.
- W4313362072 cites W2095773948 @default.
- W4313362072 cites W2097589930 @default.
- W4313362072 cites W2099067892 @default.
- W4313362072 cites W2099129819 @default.
- W4313362072 cites W2100618837 @default.
- W4313362072 cites W2101012764 @default.
- W4313362072 cites W2101284441 @default.
- W4313362072 cites W2104425103 @default.
- W4313362072 cites W2104954848 @default.
- W4313362072 cites W2106584820 @default.
- W4313362072 cites W2107661677 @default.
- W4313362072 cites W2109895173 @default.
- W4313362072 cites W2110957729 @default.
- W4313362072 cites W2111390374 @default.