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- W4313362234 endingPage "52" @default.
- W4313362234 startingPage "52" @default.
- W4313362234 abstract "Acute lung injury (ALI) is one of the adverse effects of the antineoplastic agent cisplatin (CIS). Oxidative stress, inflammation, and necroptosis are linked to the emergence of lung injury in various disorders. This study evaluated the effect of the macrolide antibiotic azithromycin (AZM) on oxidative stress, inflammatory response, and necroptosis in the lungs of CIS-administered rats, pinpointing the involvement of PPARγ, SIRT1, and Nrf2/HO-1 signaling. The rats received AZM for 10 days and a single dose of CIS on the 7th day. CIS provoked bronchial and alveolar injury along with increased levels of ROS, MDA, NO, MPO, NF-κB p65, TNF-α, and IL-1β, and decreased levels of GSH, SOD, GST, and IL-10, denoting oxidative and inflammatory responses. The necroptosis-related proteins RIP1, RIP3, MLKL, and caspase-8 were upregulated in CIS-treated rats. AZM effectively prevented lung tissue injury, ameliorated oxidative stress and NF-κB p65 and pro-inflammatory markers levels, boosted antioxidants and IL-10, and downregulated necroptosis-related proteins in CIS-administered rats. AZM decreased the concentration of Ang II and increased those of Ang (1-7), cytoglobin, PPARγ, SIRT1, Nrf2, and HO-1 in the lungs of CIS-treated rats. In conclusion, AZM attenuated the lung injury provoked by CIS in rats through the suppression of inflammation, oxidative stress, and necroptosis. The protective effect of AZM was associated with the upregulation of Nrf2/HO-1 signaling, cytoglobin, PPARγ, and SIRT1." @default.
- W4313362234 created "2023-01-06" @default.
- W4313362234 creator A5010080772 @default.
- W4313362234 creator A5012342055 @default.
- W4313362234 creator A5012491600 @default.
- W4313362234 creator A5029640435 @default.
- W4313362234 creator A5034931653 @default.
- W4313362234 creator A5040016577 @default.
- W4313362234 creator A5043618782 @default.
- W4313362234 creator A5076172971 @default.
- W4313362234 creator A5077038823 @default.
- W4313362234 creator A5091894999 @default.
- W4313362234 date "2022-12-29" @default.
- W4313362234 modified "2023-10-06" @default.
- W4313362234 title "Azithromycin Mitigates Cisplatin-Induced Lung Oxidative Stress, Inflammation and Necroptosis by Upregulating SIRT1, PPARγ, and Nrf2/HO-1 Signaling" @default.
- W4313362234 cites W1521314285 @default.
- W4313362234 cites W1691027052 @default.
- W4313362234 cites W1784764677 @default.
- W4313362234 cites W1823862173 @default.
- W4313362234 cites W1869018609 @default.
- W4313362234 cites W1966908189 @default.
- W4313362234 cites W1970917972 @default.
- W4313362234 cites W1987604182 @default.
- W4313362234 cites W1997776953 @default.
- W4313362234 cites W1999048147 @default.
- W4313362234 cites W2000165600 @default.
- W4313362234 cites W2006370393 @default.
- W4313362234 cites W2018211784 @default.
- W4313362234 cites W2020987391 @default.
- W4313362234 cites W2041376642 @default.
- W4313362234 cites W2043446682 @default.
- W4313362234 cites W2053054955 @default.
- W4313362234 cites W2060727135 @default.
- W4313362234 cites W2061360993 @default.
- W4313362234 cites W2076296181 @default.
- W4313362234 cites W2085006338 @default.
- W4313362234 cites W2086681374 @default.
- W4313362234 cites W2087019732 @default.
- W4313362234 cites W2087232320 @default.
- W4313362234 cites W2088866343 @default.
- W4313362234 cites W2090676036 @default.
- W4313362234 cites W2111157705 @default.
- W4313362234 cites W2112252897 @default.
- W4313362234 cites W2115486033 @default.
- W4313362234 cites W2116583919 @default.
- W4313362234 cites W2119425860 @default.
- W4313362234 cites W2122386753 @default.
- W4313362234 cites W2123238662 @default.
- W4313362234 cites W2127475482 @default.
- W4313362234 cites W2128635872 @default.
- W4313362234 cites W2128888799 @default.
- W4313362234 cites W2129776726 @default.
- W4313362234 cites W2133584350 @default.
- W4313362234 cites W2136484116 @default.
- W4313362234 cites W2151179480 @default.
- W4313362234 cites W2152390443 @default.
- W4313362234 cites W2156953890 @default.
- W4313362234 cites W2474045208 @default.
- W4313362234 cites W2519786994 @default.
- W4313362234 cites W2557604044 @default.
- W4313362234 cites W2564778141 @default.
- W4313362234 cites W2574819148 @default.
- W4313362234 cites W2596265142 @default.
- W4313362234 cites W2607077450 @default.
- W4313362234 cites W2748572997 @default.
- W4313362234 cites W2755606774 @default.
- W4313362234 cites W2756462278 @default.
- W4313362234 cites W2780715796 @default.
- W4313362234 cites W2781867957 @default.
- W4313362234 cites W2802942194 @default.
- W4313362234 cites W2883032164 @default.
- W4313362234 cites W2884669571 @default.
- W4313362234 cites W2896860424 @default.
- W4313362234 cites W2902247952 @default.
- W4313362234 cites W2910546024 @default.
- W4313362234 cites W2921725014 @default.
- W4313362234 cites W2923172861 @default.
- W4313362234 cites W2937766145 @default.
- W4313362234 cites W2990400835 @default.
- W4313362234 cites W3010562153 @default.
- W4313362234 cites W3010930696 @default.
- W4313362234 cites W3012362055 @default.
- W4313362234 cites W3012413501 @default.
- W4313362234 cites W3060255527 @default.
- W4313362234 cites W3094112604 @default.
- W4313362234 cites W3100239803 @default.
- W4313362234 cites W3120776852 @default.
- W4313362234 cites W3129370137 @default.
- W4313362234 cites W3161723839 @default.
- W4313362234 cites W3162771447 @default.
- W4313362234 cites W3164579384 @default.
- W4313362234 cites W3167630409 @default.
- W4313362234 cites W3205903613 @default.
- W4313362234 cites W3208711133 @default.
- W4313362234 cites W4200313877 @default.
- W4313362234 cites W4214545804 @default.
- W4313362234 cites W4220798675 @default.
- W4313362234 cites W4226213074 @default.