Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313362356> ?p ?o ?g. }
- W4313362356 endingPage "637" @default.
- W4313362356 startingPage "637" @default.
- W4313362356 abstract "Favism uniquely arises from a genetic defect of the Glucose-6 Phosphate Dehydrogenase (G6PD) enzyme and results in a severe reduction of erythrocytes' (RBCs) reducing power that impairs the cells' ability to respond to oxidative stresses. After exposure to fava beans or a few other drugs, the patients experience acute hemolytic anemia due to RBCs' lysis both intra and extra-vascularly. In the present paper, we compared selected biochemical, biophysical, and ultra-morphological properties of normal RBCs and cells from favism patients measured along cellular aging. Along the aging path, the cells' characteristics change, and their structural and functional properties degrade for both samples, but with different patterns and effectors that have been characterized in biophysical and biochemical terms. In particular, the analysis revealed distinct metabolic regulation in G6DP-deficient cells that determines important peculiarities in the cell properties during aging. Remarkably, the initial higher fragility and occurrence of structural/morphological alterations of favism cells develop, with longer aging times, into a stronger resistance to external stresses and higher general resilience. This surprisingly higher endurance against cell aging has been related to a special mechanism of metabolic regulation that permits lower energy consumption in environmental stress conditions. Our results provided a direct and coherent link between the RBCs' metabolic regulation and the cell properties that would not have been possible to establish without an investigation performed during aging. The consequences of this new knowledge, in particular, can be discussed in a more general context, such as understanding the role of the present findings in determining the characteristics of the favism pathology as a whole." @default.
- W4313362356 created "2023-01-06" @default.
- W4313362356 creator A5000720718 @default.
- W4313362356 creator A5020345404 @default.
- W4313362356 creator A5032212707 @default.
- W4313362356 creator A5035581611 @default.
- W4313362356 creator A5058036715 @default.
- W4313362356 creator A5091400923 @default.
- W4313362356 date "2022-12-30" @default.
- W4313362356 modified "2023-10-04" @default.
- W4313362356 title "Surprising Structural and Functional Properties of Favism Erythrocytes Are Linked to Special Metabolic Regulation: A Cell Aging Study" @default.
- W4313362356 cites W1524748918 @default.
- W4313362356 cites W1965615714 @default.
- W4313362356 cites W1967949532 @default.
- W4313362356 cites W1973828942 @default.
- W4313362356 cites W1983416050 @default.
- W4313362356 cites W1984380276 @default.
- W4313362356 cites W2000804108 @default.
- W4313362356 cites W2001078588 @default.
- W4313362356 cites W2002140570 @default.
- W4313362356 cites W2024200988 @default.
- W4313362356 cites W2031809080 @default.
- W4313362356 cites W2046151550 @default.
- W4313362356 cites W2048569126 @default.
- W4313362356 cites W2049438581 @default.
- W4313362356 cites W2071456460 @default.
- W4313362356 cites W2081393812 @default.
- W4313362356 cites W2083027212 @default.
- W4313362356 cites W2090860030 @default.
- W4313362356 cites W2092685467 @default.
- W4313362356 cites W2097098920 @default.
- W4313362356 cites W2118961896 @default.
- W4313362356 cites W2121231139 @default.
- W4313362356 cites W2144876956 @default.
- W4313362356 cites W2147480379 @default.
- W4313362356 cites W2166747981 @default.
- W4313362356 cites W2336431840 @default.
- W4313362356 cites W2781485586 @default.
- W4313362356 cites W2805113998 @default.
- W4313362356 cites W2805477722 @default.
- W4313362356 cites W2809831004 @default.
- W4313362356 cites W2884866789 @default.
- W4313362356 cites W2913863945 @default.
- W4313362356 cites W3036554943 @default.
- W4313362356 cites W3108523702 @default.
- W4313362356 cites W3196344700 @default.
- W4313362356 cites W4224273580 @default.
- W4313362356 cites W4241888432 @default.
- W4313362356 cites W4294733312 @default.
- W4313362356 doi "https://doi.org/10.3390/ijms24010637" @default.
- W4313362356 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36614084" @default.
- W4313362356 hasPublicationYear "2022" @default.
- W4313362356 type Work @default.
- W4313362356 citedByCount "5" @default.
- W4313362356 countsByYear W43133623562023 @default.
- W4313362356 crossrefType "journal-article" @default.
- W4313362356 hasAuthorship W4313362356A5000720718 @default.
- W4313362356 hasAuthorship W4313362356A5020345404 @default.
- W4313362356 hasAuthorship W4313362356A5032212707 @default.
- W4313362356 hasAuthorship W4313362356A5035581611 @default.
- W4313362356 hasAuthorship W4313362356A5058036715 @default.
- W4313362356 hasAuthorship W4313362356A5091400923 @default.
- W4313362356 hasBestOaLocation W43133623561 @default.
- W4313362356 hasConcept C147509754 @default.
- W4313362356 hasConcept C1491633281 @default.
- W4313362356 hasConcept C151730666 @default.
- W4313362356 hasConcept C203014093 @default.
- W4313362356 hasConcept C2776151105 @default.
- W4313362356 hasConcept C2776557347 @default.
- W4313362356 hasConcept C2779343474 @default.
- W4313362356 hasConcept C2779902561 @default.
- W4313362356 hasConcept C55493867 @default.
- W4313362356 hasConcept C57600042 @default.
- W4313362356 hasConcept C86803240 @default.
- W4313362356 hasConcept C95444343 @default.
- W4313362356 hasConceptScore W4313362356C147509754 @default.
- W4313362356 hasConceptScore W4313362356C1491633281 @default.
- W4313362356 hasConceptScore W4313362356C151730666 @default.
- W4313362356 hasConceptScore W4313362356C203014093 @default.
- W4313362356 hasConceptScore W4313362356C2776151105 @default.
- W4313362356 hasConceptScore W4313362356C2776557347 @default.
- W4313362356 hasConceptScore W4313362356C2779343474 @default.
- W4313362356 hasConceptScore W4313362356C2779902561 @default.
- W4313362356 hasConceptScore W4313362356C55493867 @default.
- W4313362356 hasConceptScore W4313362356C57600042 @default.
- W4313362356 hasConceptScore W4313362356C86803240 @default.
- W4313362356 hasConceptScore W4313362356C95444343 @default.
- W4313362356 hasIssue "1" @default.
- W4313362356 hasLocation W43133623561 @default.
- W4313362356 hasLocation W43133623562 @default.
- W4313362356 hasLocation W43133623563 @default.
- W4313362356 hasLocation W43133623564 @default.
- W4313362356 hasOpenAccess W4313362356 @default.
- W4313362356 hasPrimaryLocation W43133623561 @default.
- W4313362356 hasRelatedWork W1972774396 @default.
- W4313362356 hasRelatedWork W2035024531 @default.
- W4313362356 hasRelatedWork W2129705938 @default.
- W4313362356 hasRelatedWork W2143232160 @default.