Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313362582> ?p ?o ?g. }
- W4313362582 endingPage "150" @default.
- W4313362582 startingPage "150" @default.
- W4313362582 abstract "The apelinergic system comprises two peptide ligands, apelin and ELABELA, and their cognate G-protein-coupled receptor, the apelin receptor APJ. Apelin is a peptide that was isolated from bovine stomach extracts; the distribution of the four main active forms, apelin-36, -17, -13, and pyr-apelin-13 differs between tissues. The mature form of ELABELA-32 can be transformed into forms called ELABELA-11 or -21. The biological function of the apelinergic system is multifaceted, and includes the regulation of angiogenesis, body fluid homeostasis, energy metabolism, and functioning of the cardiovascular, nervous, respiratory, digestive, and reproductive systems. This review summarises the mechanism of the apelinergic system in cell apoptosis. Depending on the cell/tissue, the apelinergic system modulates cell apoptosis by activating various signalling pathways, including phosphoinositide 3-kinase (PI3K), extracellular signal-regulated protein kinase (ERK1/2), protein kinase B (AKT), 5'AMP-activated protein kinase(AMPK), and protein kinase A (PKA). Apoptosis is critically important during various developmental processes, and any dysfunction leads to pathological conditions such as cancer, autoimmune diseases, and developmental defects. The purpose of this review is to present data that suggest a significant role of the apelinergic system as a potential agent in various therapies." @default.
- W4313362582 created "2023-01-06" @default.
- W4313362582 creator A5002860484 @default.
- W4313362582 creator A5052509593 @default.
- W4313362582 creator A5057732854 @default.
- W4313362582 creator A5071206009 @default.
- W4313362582 creator A5084306838 @default.
- W4313362582 creator A5090668417 @default.
- W4313362582 date "2022-12-30" @default.
- W4313362582 modified "2023-10-05" @default.
- W4313362582 title "The Apelinergic System: Apelin, ELABELA, and APJ Action on Cell Apoptosis: Anti-Apoptotic or Pro-Apoptotic Effect?" @default.
- W4313362582 cites W142053782 @default.
- W4313362582 cites W1511152517 @default.
- W4313362582 cites W1608258137 @default.
- W4313362582 cites W1893068748 @default.
- W4313362582 cites W1914811682 @default.
- W4313362582 cites W1955514206 @default.
- W4313362582 cites W1966741491 @default.
- W4313362582 cites W1969729916 @default.
- W4313362582 cites W1973342839 @default.
- W4313362582 cites W1974953974 @default.
- W4313362582 cites W1976699663 @default.
- W4313362582 cites W1979074215 @default.
- W4313362582 cites W1989037172 @default.
- W4313362582 cites W1989706089 @default.
- W4313362582 cites W1991546524 @default.
- W4313362582 cites W1997813854 @default.
- W4313362582 cites W1997902188 @default.
- W4313362582 cites W2011110796 @default.
- W4313362582 cites W2013824152 @default.
- W4313362582 cites W2040758907 @default.
- W4313362582 cites W2046962004 @default.
- W4313362582 cites W2057556321 @default.
- W4313362582 cites W2060660919 @default.
- W4313362582 cites W2061575153 @default.
- W4313362582 cites W2066150277 @default.
- W4313362582 cites W2073536490 @default.
- W4313362582 cites W2077652055 @default.
- W4313362582 cites W2078239070 @default.
- W4313362582 cites W2082263940 @default.
- W4313362582 cites W2087458930 @default.
- W4313362582 cites W2087867260 @default.
- W4313362582 cites W2098223295 @default.
- W4313362582 cites W2098382903 @default.
- W4313362582 cites W2103202991 @default.
- W4313362582 cites W2104067489 @default.
- W4313362582 cites W2104487713 @default.
- W4313362582 cites W2105642488 @default.
- W4313362582 cites W2106530664 @default.
- W4313362582 cites W2116332483 @default.
- W4313362582 cites W2119230474 @default.
- W4313362582 cites W2129224037 @default.
- W4313362582 cites W2131918497 @default.
- W4313362582 cites W2132493114 @default.
- W4313362582 cites W2135128960 @default.
- W4313362582 cites W2136012004 @default.
- W4313362582 cites W2138041547 @default.
- W4313362582 cites W2138561646 @default.
- W4313362582 cites W2142392754 @default.
- W4313362582 cites W2152292763 @default.
- W4313362582 cites W2152479803 @default.
- W4313362582 cites W2152509794 @default.
- W4313362582 cites W2161153797 @default.
- W4313362582 cites W2162185858 @default.
- W4313362582 cites W2163674972 @default.
- W4313362582 cites W2163865644 @default.
- W4313362582 cites W2165312739 @default.
- W4313362582 cites W2173571785 @default.
- W4313362582 cites W2174927336 @default.
- W4313362582 cites W2180268264 @default.
- W4313362582 cites W2293099900 @default.
- W4313362582 cites W2296782701 @default.
- W4313362582 cites W2307812674 @default.
- W4313362582 cites W2404169872 @default.
- W4313362582 cites W2465905300 @default.
- W4313362582 cites W2467062313 @default.
- W4313362582 cites W2501143949 @default.
- W4313362582 cites W2525935504 @default.
- W4313362582 cites W2526516762 @default.
- W4313362582 cites W2580543927 @default.
- W4313362582 cites W2583089302 @default.
- W4313362582 cites W2600855685 @default.
- W4313362582 cites W2604287073 @default.
- W4313362582 cites W2728308062 @default.
- W4313362582 cites W2784283336 @default.
- W4313362582 cites W2806292632 @default.
- W4313362582 cites W2892446993 @default.
- W4313362582 cites W2895085252 @default.
- W4313362582 cites W2905354282 @default.
- W4313362582 cites W2921138431 @default.
- W4313362582 cites W2932590582 @default.
- W4313362582 cites W2934080558 @default.
- W4313362582 cites W2951911900 @default.
- W4313362582 cites W2954042878 @default.
- W4313362582 cites W2963442200 @default.
- W4313362582 cites W2965060798 @default.
- W4313362582 cites W2978314883 @default.
- W4313362582 cites W2994276827 @default.