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- W4313362756 abstract "Temoporfin (mTHPC) is approved in Europe for the photodynamic treatment of head and neck squamous cell carcinoma (HNSCC). Although it has a promising profile, its lipophilic character hampers the full exploitation of its potential due to high tendency of aggregation and a reduced ROS generation that compromise photodynamic therapy (PDT) efficacy. Moreover, for its clinical administration, mTHPC requires the presence of ethanol and propylene glycol as solvents, often causing adverse effects in the site of injection. In this paper we explored the efficiency of a new mTHPC formulation that uses human serum albumin (HSA) to disperse the photosensitizer in solution (mTHPC@HSA), investigating its anticancer potential in two HNSCC cell lines. Through a comprehensive characterization, we demonstrated that mTHPC@HSA is stable in physiological environment, does not aggregate, and is extremely efficient in PDT performance, due to its high singlet oxygen generation and the high dispersion as monomolecular form in HSA. This is supported by the computational identification of the specific binding pocket of mTHPC in HSA. Moreover, mTHPC@HSA-PDT induces cytotoxicity in both HNSCC cell lines, increasing intracellular ROS generation and the number of γ-H2AX foci, a cellular event involved in the global response to cellular stress. Taken together these results highlight the promising phototoxic profile of the complex, prompting further studies to assess its clinical potential." @default.
- W4313362756 created "2023-01-06" @default.
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- W4313362756 date "2022-12-29" @default.
- W4313362756 modified "2023-10-16" @default.
- W4313362756 title "Carrying Temoporfin with Human Serum Albumin: A New Perspective for Photodynamic Application in Head and Neck Cancer" @default.
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- W4313362756 cites W1877053426 @default.
- W4313362756 cites W1964268409 @default.
- W4313362756 cites W1968128233 @default.
- W4313362756 cites W1968984443 @default.
- W4313362756 cites W1980780168 @default.
- W4313362756 cites W1995443816 @default.
- W4313362756 cites W2004479258 @default.
- W4313362756 cites W2006680805 @default.
- W4313362756 cites W2009677760 @default.
- W4313362756 cites W2029667189 @default.
- W4313362756 cites W2029778533 @default.
- W4313362756 cites W2031146082 @default.
- W4313362756 cites W2032668826 @default.
- W4313362756 cites W2033895480 @default.
- W4313362756 cites W2041806227 @default.
- W4313362756 cites W2043984207 @default.
- W4313362756 cites W2065530139 @default.
- W4313362756 cites W2073517256 @default.
- W4313362756 cites W2088895925 @default.
- W4313362756 cites W2090287369 @default.
- W4313362756 cites W2090288682 @default.
- W4313362756 cites W2110389830 @default.
- W4313362756 cites W2115914766 @default.
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- W4313362756 cites W2151460035 @default.
- W4313362756 cites W2152604288 @default.
- W4313362756 cites W2162680672 @default.
- W4313362756 cites W2312739601 @default.
- W4313362756 cites W2326813838 @default.
- W4313362756 cites W2344955738 @default.
- W4313362756 cites W2394601969 @default.
- W4313362756 cites W2396533937 @default.
- W4313362756 cites W2404280981 @default.
- W4313362756 cites W2544053838 @default.
- W4313362756 cites W2578899916 @default.
- W4313362756 cites W2609812443 @default.
- W4313362756 cites W2753218109 @default.
- W4313362756 cites W2790788081 @default.
- W4313362756 cites W2801545416 @default.
- W4313362756 cites W2883860383 @default.
- W4313362756 cites W2905117119 @default.
- W4313362756 cites W2905266961 @default.
- W4313362756 cites W2945303331 @default.
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- W4313362756 cites W2966666184 @default.
- W4313362756 cites W2972475127 @default.
- W4313362756 cites W2980065497 @default.
- W4313362756 cites W2982394705 @default.
- W4313362756 cites W2995497665 @default.
- W4313362756 cites W3011862897 @default.
- W4313362756 cites W3016631005 @default.
- W4313362756 cites W3038140440 @default.
- W4313362756 cites W3041246143 @default.
- W4313362756 cites W3082087158 @default.
- W4313362756 cites W3107533236 @default.
- W4313362756 cites W3135519087 @default.
- W4313362756 cites W3165807342 @default.
- W4313362756 cites W3178845403 @default.
- W4313362756 cites W3213115332 @default.
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- W4313362756 doi "https://doi.org/10.3390/biom13010068" @default.
- W4313362756 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36671454" @default.
- W4313362756 hasPublicationYear "2022" @default.
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