FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313362872> ?p ?o ?g. }

• W4313362872 endingPage "232" @default.
• W4313362872 startingPage "226" @default.
• W4313362872 abstract "Monogenic obesity is a rare, early-onset, and severe form of obesity that has a Mendelian inheritance pattern, high penetrance, and large genetic effect. In contrast, common polygenic obesity is more prevalent and has pattern of heritability derived from many variants in several genes with low penetrance. This influences phenotype interaction with environmental factors. However, the influence of genetics on obesity is a continuous spectrum rather than the distinct classification. Genetic studies have found that leptin-melanocortin pathway is a key circuit in regulating appetite, satiety, and body weight, and most cases of monogenic obesity result from defects in this pathway. Genetic variations associated with common polygenic obesity have been found by population- based association studies, such as genome-wide association studies (GWAS). GWAS have discovered many obesity-associated loci, the majority of which harbor genes identified in monogenic obesity involving the leptin-melanocortin pathway. Genetic insights have enabled in not only understanding the molecular mechanisms and biology of obesity, but also in the development of novel therapeutic drugs for several types of monogenic obesity in the context of precision medicine. Moreover, therapeutic approaches could work in common polygenic obesity given that the genetic variations identified in the leptin-melanocortin circuit also plays a role in common polygenic obesity." @default.
• W4313362872 created "2023-01-06" @default.
• W4313362872 creator A5090657001 @default.
• W4313362872 date "2022-12-31" @default.
• W4313362872 modified "2023-09-30" @default.
• W4313362872 title "The genetics of obesity: A narrative review" @default.
• W4313362872 cites W1490475088 @default.
• W4313362872 cites W1539401343 @default.
• W4313362872 cites W1965574341 @default.
• W4313362872 cites W1989111033 @default.
• W4313362872 cites W1994545264 @default.
• W4313362872 cites W2054706730 @default.
• W4313362872 cites W2110678911 @default.
• W4313362872 cites W2115594567 @default.
• W4313362872 cites W2129150286 @default.
• W4313362872 cites W2137189444 @default.
• W4313362872 cites W2145707775 @default.
• W4313362872 cites W2150220906 @default.
• W4313362872 cites W2155580582 @default.
• W4313362872 cites W2160679927 @default.
• W4313362872 cites W2162896556 @default.
• W4313362872 cites W2319361543 @default.
• W4313362872 cites W2437007381 @default.
• W4313362872 cites W2503348180 @default.
• W4313362872 cites W2560427353 @default.
• W4313362872 cites W2607431550 @default.
• W4313362872 cites W2759404744 @default.
• W4313362872 cites W2901303766 @default.
• W4313362872 cites W2914006242 @default.
• W4313362872 cites W2982338055 @default.
• W4313362872 cites W3027864372 @default.
• W4313362872 cites W3038569469 @default.
• W4313362872 cites W3049159448 @default.
• W4313362872 cites W3095455148 @default.
• W4313362872 cites W3132203767 @default.
• W4313362872 cites W3134781470 @default.
• W4313362872 cites W3157614340 @default.
• W4313362872 cites W3199205086 @default.
• W4313362872 cites W4206462178 @default.
• W4313362872 cites W4288084869 @default.
• W4313362872 cites W4297982754 @default.
• W4313362872 doi "https://doi.org/10.23838/pfm.2022.00156" @default.
• W4313362872 hasPublicationYear "2022" @default.
• W4313362872 type Work @default.
• W4313362872 citedByCount "0" @default.
• W4313362872 crossrefType "journal-article" @default.
• W4313362872 hasAuthorship W4313362872A5090657001 @default.
• W4313362872 hasBestOaLocation W43133628721 @default.
• W4313362872 hasConcept C104317684 @default.
• W4313362872 hasConcept C106208931 @default.
• W4313362872 hasConcept C127716648 @default.
• W4313362872 hasConcept C134018914 @default.
• W4313362872 hasConcept C135763542 @default.
• W4313362872 hasConcept C144621757 @default.
• W4313362872 hasConcept C151730666 @default.
• W4313362872 hasConcept C153209595 @default.
• W4313362872 hasConcept C161890455 @default.
• W4313362872 hasConcept C175783326 @default.
• W4313362872 hasConcept C186413461 @default.
• W4313362872 hasConcept C200544954 @default.
• W4313362872 hasConcept C2779343474 @default.
• W4313362872 hasConcept C2908647359 @default.
• W4313362872 hasConcept C2910691881 @default.
• W4313362872 hasConcept C511355011 @default.
• W4313362872 hasConcept C54355233 @default.
• W4313362872 hasConcept C60644358 @default.
• W4313362872 hasConcept C69991583 @default.
• W4313362872 hasConcept C71924100 @default.
• W4313362872 hasConcept C86803240 @default.
• W4313362872 hasConcept C99454951 @default.
• W4313362872 hasConceptScore W4313362872C104317684 @default.
• W4313362872 hasConceptScore W4313362872C106208931 @default.
• W4313362872 hasConceptScore W4313362872C127716648 @default.
• W4313362872 hasConceptScore W4313362872C134018914 @default.
• W4313362872 hasConceptScore W4313362872C135763542 @default.
• W4313362872 hasConceptScore W4313362872C144621757 @default.
• W4313362872 hasConceptScore W4313362872C151730666 @default.
• W4313362872 hasConceptScore W4313362872C153209595 @default.
• W4313362872 hasConceptScore W4313362872C161890455 @default.
• W4313362872 hasConceptScore W4313362872C175783326 @default.
• W4313362872 hasConceptScore W4313362872C186413461 @default.
• W4313362872 hasConceptScore W4313362872C200544954 @default.
• W4313362872 hasConceptScore W4313362872C2779343474 @default.
• W4313362872 hasConceptScore W4313362872C2908647359 @default.
• W4313362872 hasConceptScore W4313362872C2910691881 @default.
• W4313362872 hasConceptScore W4313362872C511355011 @default.
• W4313362872 hasConceptScore W4313362872C54355233 @default.
• W4313362872 hasConceptScore W4313362872C60644358 @default.
• W4313362872 hasConceptScore W4313362872C69991583 @default.
• W4313362872 hasConceptScore W4313362872C71924100 @default.
• W4313362872 hasConceptScore W4313362872C86803240 @default.
• W4313362872 hasConceptScore W4313362872C99454951 @default.
• W4313362872 hasIssue "4" @default.
• W4313362872 hasLocation W43133628721 @default.
• W4313362872 hasOpenAccess W4313362872 @default.
• W4313362872 hasPrimaryLocation W43133628721 @default.
• W4313362872 hasRelatedWork W159064268 @default.
• W4313362872 hasRelatedWork W178865484 @default.

• next