Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313362914> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W4313362914 endingPage "231" @default.
- W4313362914 startingPage "225" @default.
- W4313362914 abstract "Objective: CD5+CD19+ cells have a low proliferation capacity and elevated expression of anti-apoptotic protein BCL-2, mostly in the G0/ G1 cell phase and accumulate in the pathogenesis of chronic lymphocytic leukemia (CLL). Natural killer (NK) cells have the ability to kill the intracellular pathogen-infected or cancer cells and secrete cytotoxic enzymes. This study evaluated the frequency, expression of cytotoxic enzymes, and intracellular cytokine levels of NK cells in CLL patients. Materials and Methods: In this study, peripheral blood mononuclear cells were isolated from peripheral blood samples of CLL patients (n=29) and healthy controls (n=16) by density gradient centrifugation method. The frequency of the total NK cells and the intracellular levels of perforin, granzyme, interferon (IFN)-γ, interleukin (IL)-21, IL-4 and IL-17 in NK cells were investigated. Results: Elevated total NK cell frequency were found in the CLL patients compared to the healthy controls, and negatively correlated with CD5+CD19+ malign B cell frequency. Increased perforin expression was observed in patients’ total NK cells. Additionally, increased levels of IL-17 and IL-21 in total NK cell of CLL patients were obtained compared to healthy subjects. Conclusion: The findings suggest that in the early stage of CLL, increased total NK cell frequency, and elevated perforin and IL-21 levels in NK cells might have a protective impact against the progression of the disease for CLL patients." @default.
- W4313362914 created "2023-01-06" @default.
- W4313362914 creator A5007221637 @default.
- W4313362914 creator A5019981900 @default.
- W4313362914 creator A5024471593 @default.
- W4313362914 creator A5024764830 @default.
- W4313362914 creator A5066209076 @default.
- W4313362914 creator A5080106234 @default.
- W4313362914 creator A5089492553 @default.
- W4313362914 date "2022-12-30" @default.
- W4313362914 modified "2023-10-18" @default.
- W4313362914 title "Increased Perforin- and IL-21-Expressing NK Cells in Patients with Early-Stage Chronic Lymphocytic Leukemia" @default.
- W4313362914 doi "https://doi.org/10.26650/experimed.1191622" @default.
- W4313362914 hasPublicationYear "2022" @default.
- W4313362914 type Work @default.
- W4313362914 citedByCount "0" @default.
- W4313362914 crossrefType "journal-article" @default.
- W4313362914 hasAuthorship W4313362914A5007221637 @default.
- W4313362914 hasAuthorship W4313362914A5019981900 @default.
- W4313362914 hasAuthorship W4313362914A5024471593 @default.
- W4313362914 hasAuthorship W4313362914A5024764830 @default.
- W4313362914 hasAuthorship W4313362914A5066209076 @default.
- W4313362914 hasAuthorship W4313362914A5080106234 @default.
- W4313362914 hasAuthorship W4313362914A5089492553 @default.
- W4313362914 hasConcept C129374314 @default.
- W4313362914 hasConcept C137061746 @default.
- W4313362914 hasConcept C149532602 @default.
- W4313362914 hasConcept C154317977 @default.
- W4313362914 hasConcept C167672396 @default.
- W4313362914 hasConcept C183193105 @default.
- W4313362914 hasConcept C202751555 @default.
- W4313362914 hasConcept C203014093 @default.
- W4313362914 hasConcept C2776062744 @default.
- W4313362914 hasConcept C2776090121 @default.
- W4313362914 hasConcept C2777938653 @default.
- W4313362914 hasConcept C2778461978 @default.
- W4313362914 hasConcept C2778957590 @default.
- W4313362914 hasConcept C2779968557 @default.
- W4313362914 hasConcept C2780380082 @default.
- W4313362914 hasConcept C55493867 @default.
- W4313362914 hasConcept C86803240 @default.
- W4313362914 hasConcept C8891405 @default.
- W4313362914 hasConceptScore W4313362914C129374314 @default.
- W4313362914 hasConceptScore W4313362914C137061746 @default.
- W4313362914 hasConceptScore W4313362914C149532602 @default.
- W4313362914 hasConceptScore W4313362914C154317977 @default.
- W4313362914 hasConceptScore W4313362914C167672396 @default.
- W4313362914 hasConceptScore W4313362914C183193105 @default.
- W4313362914 hasConceptScore W4313362914C202751555 @default.
- W4313362914 hasConceptScore W4313362914C203014093 @default.
- W4313362914 hasConceptScore W4313362914C2776062744 @default.
- W4313362914 hasConceptScore W4313362914C2776090121 @default.
- W4313362914 hasConceptScore W4313362914C2777938653 @default.
- W4313362914 hasConceptScore W4313362914C2778461978 @default.
- W4313362914 hasConceptScore W4313362914C2778957590 @default.
- W4313362914 hasConceptScore W4313362914C2779968557 @default.
- W4313362914 hasConceptScore W4313362914C2780380082 @default.
- W4313362914 hasConceptScore W4313362914C55493867 @default.
- W4313362914 hasConceptScore W4313362914C86803240 @default.
- W4313362914 hasConceptScore W4313362914C8891405 @default.
- W4313362914 hasIssue "3" @default.
- W4313362914 hasLocation W43133629141 @default.
- W4313362914 hasOpenAccess W4313362914 @default.
- W4313362914 hasPrimaryLocation W43133629141 @default.
- W4313362914 hasRelatedWork W1797677206 @default.
- W4313362914 hasRelatedWork W1969504080 @default.
- W4313362914 hasRelatedWork W2017949628 @default.
- W4313362914 hasRelatedWork W2042623890 @default.
- W4313362914 hasRelatedWork W2048773810 @default.
- W4313362914 hasRelatedWork W2130431539 @default.
- W4313362914 hasRelatedWork W2991630458 @default.
- W4313362914 hasRelatedWork W3032016103 @default.
- W4313362914 hasRelatedWork W3122126102 @default.
- W4313362914 hasRelatedWork W3159185942 @default.
- W4313362914 hasVolume "12" @default.
- W4313362914 isParatext "false" @default.
- W4313362914 isRetracted "false" @default.
- W4313362914 workType "article" @default.