FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313362921> ?p ?o ?g. }

• W4313362921 endingPage "433" @default.
• W4313362921 startingPage "420" @default.
• W4313362921 abstract "Phenosanic acid prevents convulsions, reduces the frequency of epileptic seizures, and improves cognitive, intellectual and mnestic functions in patients with epilepsy. Therefore, phenosanic acid-based medicinal products are promising candidates for inclusion in combination antiepileptic therapy. In order to combine medicinal products rationally and ensure that the therapy is safe, it is useful to study the pharmacokinetic interaction of medicinal products planned for clinical co-administration. The aim of the study was to examine single-dose pharmacokinetic interactions between Dibufelon ® 200 mg capsules (PIQ-PHARMA LLC, Russia) and two medicinal products planned for clinical co-application with it, namely, valproic acid and carbamazepine, in sexually mature dogs. Materials and methods: the study included medicinal products of phenosanic acid (Dibufelon ® 200 mg capsules by PIQ-PHARMA LLC, Russia), valproic acid (300 mg prolonged-release film-coated tablets), and carbamazepine (200 mg tablets). The medicinal products were administered to beagle dogs (2 groups of 9 males each) as a single oral dose separately and in the following combinations: phenosanic acid with valproic acid and phenosanic acid with carbamazepine. Dose selection involved adjusting maximum human therapeutic doses using interspecies conversion factors. Phenosanic acid was administered at a dose of 24 mg/kg; valproic acid and carbamazepine were administered at a dose of 60 mg/kg. Blood sampling took place at baseline and in 0.5, 0.75, 1, 2, 4, 6, 8, 10, and 24 h after dosing. Plasma concentrations of active substances were determined by HPLC-UV. Pharmacokinetic interactions were evaluated by changes in the main pharmacokinetic parameters ( С max , Т max , AUC 0-24 , MRT, Т 1/2 ). Results: the study demonstrated rapid gastrointestinal absorption and prolonged systemic circulation of phenosanic acid administered separately ( T max 2–4 h, T 1/2 13–28 h) and combined with valproic acid ( T max 2 h, T 1/2 22 h). When administered with carbamazepine, phenosanic acid was eliminated from the systemic blood flow faster ( T 1/2 7.4 h). Conclusions: co-administration of phenosanic acid and valproic acid medicinal products had no significant effect on their respective pharmacokinetics. Whereas, the combination of phenosanic acid and carbamazepine demonstrated a significant decrease in the T max values of phenosanic acid and the MRT values of carbamazepine. The pharmacokinetic changes suggestive of a possible interaction between phenosanic acid and carbamazepine need further clinical investigation." @default.
• W4313362921 created "2023-01-06" @default.
• W4313362921 creator A5006820791 @default.
• W4313362921 creator A5007957172 @default.
• W4313362921 creator A5024076283 @default.
• W4313362921 creator A5051319556 @default.
• W4313362921 creator A5056788938 @default.
• W4313362921 creator A5064843780 @default.
• W4313362921 creator A5067929631 @default.
• W4313362921 date "2022-12-29" @default.
• W4313362921 modified "2023-09-27" @default.
• W4313362921 title "Pharmacokinetic Interactions of Phenosanic Acid with Valproic Acid and Carbamazepine in Dogs" @default.
• W4313362921 cites W1986975701 @default.
• W4313362921 cites W2010847506 @default.
• W4313362921 cites W2046918650 @default.
• W4313362921 cites W2049395613 @default.
• W4313362921 cites W2063909696 @default.
• W4313362921 cites W2094089029 @default.
• W4313362921 cites W2784180820 @default.
• W4313362921 cites W2889439737 @default.
• W4313362921 cites W2904954183 @default.
• W4313362921 cites W2922482371 @default.
• W4313362921 cites W2944872299 @default.
• W4313362921 cites W3036624573 @default.
• W4313362921 cites W3132367509 @default.
• W4313362921 cites W3194602146 @default.
• W4313362921 cites W4206038564 @default.
• W4313362921 cites W4308572248 @default.
• W4313362921 doi "https://doi.org/10.30895/2312-7821-2022-10-4-420-433" @default.
• W4313362921 hasPublicationYear "2022" @default.
• W4313362921 type Work @default.
• W4313362921 citedByCount "0" @default.
• W4313362921 crossrefType "journal-article" @default.
• W4313362921 hasAuthorship W4313362921A5006820791 @default.
• W4313362921 hasAuthorship W4313362921A5007957172 @default.
• W4313362921 hasAuthorship W4313362921A5024076283 @default.
• W4313362921 hasAuthorship W4313362921A5051319556 @default.
• W4313362921 hasAuthorship W4313362921A5056788938 @default.
• W4313362921 hasAuthorship W4313362921A5064843780 @default.
• W4313362921 hasAuthorship W4313362921A5067929631 @default.
• W4313362921 hasBestOaLocation W43133629211 @default.
• W4313362921 hasConcept C112705442 @default.
• W4313362921 hasConcept C118552586 @default.
• W4313362921 hasConcept C126322002 @default.
• W4313362921 hasConcept C185592680 @default.
• W4313362921 hasConcept C2775858608 @default.
• W4313362921 hasConcept C2776820430 @default.
• W4313362921 hasConcept C2777172819 @default.
• W4313362921 hasConcept C2777288759 @default.
• W4313362921 hasConcept C2778186239 @default.
• W4313362921 hasConcept C2779253243 @default.
• W4313362921 hasConcept C71924100 @default.
• W4313362921 hasConcept C98274493 @default.
• W4313362921 hasConceptScore W4313362921C112705442 @default.
• W4313362921 hasConceptScore W4313362921C118552586 @default.
• W4313362921 hasConceptScore W4313362921C126322002 @default.
• W4313362921 hasConceptScore W4313362921C185592680 @default.
• W4313362921 hasConceptScore W4313362921C2775858608 @default.
• W4313362921 hasConceptScore W4313362921C2776820430 @default.
• W4313362921 hasConceptScore W4313362921C2777172819 @default.
• W4313362921 hasConceptScore W4313362921C2777288759 @default.
• W4313362921 hasConceptScore W4313362921C2778186239 @default.
• W4313362921 hasConceptScore W4313362921C2779253243 @default.
• W4313362921 hasConceptScore W4313362921C71924100 @default.
• W4313362921 hasConceptScore W4313362921C98274493 @default.
• W4313362921 hasIssue "4" @default.
• W4313362921 hasLocation W43133629211 @default.
• W4313362921 hasOpenAccess W4313362921 @default.
• W4313362921 hasPrimaryLocation W43133629211 @default.
• W4313362921 hasRelatedWork W1964650076 @default.
• W4313362921 hasRelatedWork W1964759623 @default.
• W4313362921 hasRelatedWork W2074714060 @default.
• W4313362921 hasRelatedWork W2169089411 @default.
• W4313362921 hasRelatedWork W2285900047 @default.
• W4313362921 hasRelatedWork W2351073178 @default.
• W4313362921 hasRelatedWork W2419082802 @default.
• W4313362921 hasRelatedWork W2923907295 @default.
• W4313362921 hasRelatedWork W4313362921 @default.
• W4313362921 hasRelatedWork W50701402 @default.
• W4313362921 hasVolume "10" @default.
• W4313362921 isParatext "false" @default.
• W4313362921 isRetracted "false" @default.
• W4313362921 workType "article" @default.