FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313365202> ?p ?o ?g. }

• W4313365202 abstract "Abstract Background Breast cancer stem cells (BCSCs) have a crucial role in breast carcinogenesis, development, and progression. The aim of the current study is to characterize the BCSCs through the genetic profiling of different BCSCs phenotypic subsets to determine their related genetic pathways. Methods Fresh tumor tissue samples were obtained from 31 breast cancer (BC) patients for (1) Mammosphere culture. (2) Magnetic separation of the BCSCs subsets using CD24, CD44, and CD326 Microbeads. (3) Flow cytometry (FCM) assay using CD44, CD24, and EpCAM. (4) RT-PCR profiler Arrays using stem cell (SC) panel of 84 genes for four group of cells (1) CD44 + /CD24 − /EpCAM − BCSCs, (2) CD44 + /CD24 − /EpCAM + BCSCs, (3) mammospheres, and (4) normal breast tissues. Results The BCSCs (CD44 + /CD24 − /EpCAM − ) showed significant downregulation in 13 genes and upregulation in 15, where the CD44 , GJB1 and GDF3 showed the maximal expression (P = 0.001, P = 0.003 and P = 0.007); respectively). The CD44 + /CD24 − /EpCAM + BCSCs showed significant upregulation in 28 genes, where the CD44, GDF3, and GJB1 showed maximal expression (P < 0.001, P = 0.001 and P = 0.003; respectively). The mammospheres showed significant downregulation in 9 genes and a significant upregulation in 35 genes. The maximal overexpression was observed in GJB1 and FGF2 (P = 0.001, P = 0.001; respectively). The genes which achieved significant overexpression in all SC subsets were CD44, COL9A1, FGF1, FGF2, GDF3, GJA1, GJB1, GJB2, HSPA9, and KRT15. While significant downregulation in BMP2, BMP3, EP300, and KAT8. The genes which were differentially expressed by the mammospheres compared to the other BCSC subsets were CCND2, FGF3, CD4 , WNT1 , KAT2A, NUMB , ACAN, COL2A1 , TUBB3 , ASCL2, FOXA2, ISL1 , DTX1, and DVL1. Conclusion BCSCs have specific molecular profiles that differ according to their phenotypes which could affect patients’ prognosis and outcome." @default.
• W4313365202 created "2023-01-06" @default.
• W4313365202 creator A5016320447 @default.
• W4313365202 creator A5023765521 @default.
• W4313365202 creator A5033406657 @default.
• W4313365202 creator A5038538552 @default.
• W4313365202 creator A5054854912 @default.
• W4313365202 creator A5071583066 @default.
• W4313365202 date "2022-12-31" @default.
• W4313365202 modified "2023-09-26" @default.
• W4313365202 title "Genetic profiling of different phenotypic subsets of breast cancer stem cells (BCSCs) in breast cancer patients" @default.
• W4313365202 cites W1833050134 @default.
• W4313365202 cites W1940858135 @default.
• W4313365202 cites W1983201135 @default.
• W4313365202 cites W2001627351 @default.
• W4313365202 cites W2008749520 @default.
• W4313365202 cites W2023427658 @default.
• W4313365202 cites W2035023838 @default.
• W4313365202 cites W2037632318 @default.
• W4313365202 cites W2045066549 @default.
• W4313365202 cites W2046558067 @default.
• W4313365202 cites W2050300062 @default.
• W4313365202 cites W2081944219 @default.
• W4313365202 cites W2089361444 @default.
• W4313365202 cites W2127617517 @default.
• W4313365202 cites W2131994307 @default.
• W4313365202 cites W2137052967 @default.
• W4313365202 cites W2143336748 @default.
• W4313365202 cites W2151138778 @default.
• W4313365202 cites W2153646261 @default.
• W4313365202 cites W2169985187 @default.
• W4313365202 cites W2170086508 @default.
• W4313365202 cites W2171313040 @default.
• W4313365202 cites W2600998739 @default.
• W4313365202 cites W2772747905 @default.
• W4313365202 cites W2900766910 @default.
• W4313365202 cites W2945739244 @default.
• W4313365202 cites W2962063966 @default.
• W4313365202 cites W2981076470 @default.
• W4313365202 cites W3008440714 @default.
• W4313365202 cites W3010944313 @default.
• W4313365202 cites W3010978545 @default.
• W4313365202 cites W3021305401 @default.
• W4313365202 cites W3024023360 @default.
• W4313365202 cites W3025609340 @default.
• W4313365202 cites W3037338295 @default.
• W4313365202 cites W3040840747 @default.
• W4313365202 cites W3107507089 @default.
• W4313365202 cites W3119969014 @default.
• W4313365202 cites W3128149784 @default.
• W4313365202 cites W3128646645 @default.
• W4313365202 cites W3155531365 @default.
• W4313365202 doi "https://doi.org/10.1186/s12935-022-02841-2" @default.
• W4313365202 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36585652" @default.
• W4313365202 hasPublicationYear "2022" @default.
• W4313365202 type Work @default.
• W4313365202 citedByCount "1" @default.
• W4313365202 countsByYear W43133652022023 @default.
• W4313365202 crossrefType "journal-article" @default.
• W4313365202 hasAuthorship W4313365202A5016320447 @default.
• W4313365202 hasAuthorship W4313365202A5023765521 @default.
• W4313365202 hasAuthorship W4313365202A5033406657 @default.
• W4313365202 hasAuthorship W4313365202A5038538552 @default.
• W4313365202 hasAuthorship W4313365202A5054854912 @default.
• W4313365202 hasAuthorship W4313365202A5071583066 @default.
• W4313365202 hasBestOaLocation W43133652021 @default.
• W4313365202 hasConcept C104317684 @default.
• W4313365202 hasConcept C121608353 @default.
• W4313365202 hasConcept C127561419 @default.
• W4313365202 hasConcept C1491633281 @default.
• W4313365202 hasConcept C2779492189 @default.
• W4313365202 hasConcept C2780932548 @default.
• W4313365202 hasConcept C28328180 @default.
• W4313365202 hasConcept C502942594 @default.
• W4313365202 hasConcept C530470458 @default.
• W4313365202 hasConcept C54355233 @default.
• W4313365202 hasConcept C55427017 @default.
• W4313365202 hasConcept C555283112 @default.
• W4313365202 hasConcept C71924100 @default.
• W4313365202 hasConcept C86803240 @default.
• W4313365202 hasConceptScore W4313365202C104317684 @default.
• W4313365202 hasConceptScore W4313365202C121608353 @default.
• W4313365202 hasConceptScore W4313365202C127561419 @default.
• W4313365202 hasConceptScore W4313365202C1491633281 @default.
• W4313365202 hasConceptScore W4313365202C2779492189 @default.
• W4313365202 hasConceptScore W4313365202C2780932548 @default.
• W4313365202 hasConceptScore W4313365202C28328180 @default.
• W4313365202 hasConceptScore W4313365202C502942594 @default.
• W4313365202 hasConceptScore W4313365202C530470458 @default.
• W4313365202 hasConceptScore W4313365202C54355233 @default.
• W4313365202 hasConceptScore W4313365202C55427017 @default.
• W4313365202 hasConceptScore W4313365202C555283112 @default.
• W4313365202 hasConceptScore W4313365202C71924100 @default.
• W4313365202 hasConceptScore W4313365202C86803240 @default.
• W4313365202 hasIssue "1" @default.
• W4313365202 hasLocation W43133652021 @default.
• W4313365202 hasLocation W43133652022 @default.
• W4313365202 hasLocation W43133652023 @default.
• W4313365202 hasOpenAccess W4313365202 @default.
• W4313365202 hasPrimaryLocation W43133652021 @default.

• next