Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313365561> ?p ?o ?g. }
- W4313365561 abstract "Abstract Exercise training prevents age-related decline in muscle function. Targeting epigenetic aging is a promising actionable mechanism and late-life exercise mitigates epigenetic aging in rodent muscle. Whether exercise training can decelerate, or reverse epigenetic aging in humans is unknown. Here, we performed a powerful meta-analysis of the methylome and transcriptome of an unprecedented number of human skeletal muscle samples (n = 3,176). We show that: 1) individuals with higher baseline aerobic fitness have younger epigenetic and transcriptomic profiles, 2) exercise training leads to significant shifts of epigenetic and transcriptomic patterns towards a younger profile, and 3) muscle disuse “ages” the transcriptome. Higher fitness levels were associated with attenuated differential methylation and transcription during aging. Furthermore, both epigenetic and transcriptomic profiles shifted towards a younger state after exercise training interventions, while the transcriptome shifted towards an older state after forced muscle disuse. We demonstrate that exercise training targets many of the age-related transcripts and DNA methylation loci to maintain younger methylome and transcriptome profiles, specifically in genes related to muscle structure, metabolism and mitochondrial function. Our comprehensive analysis will inform future studies aiming to identify the best combination of therapeutics and exercise regimes to optimize longevity." @default.
- W4313365561 created "2023-01-06" @default.
- W4313365561 creator A5000866302 @default.
- W4313365561 creator A5004379567 @default.
- W4313365561 creator A5015015165 @default.
- W4313365561 creator A5015479543 @default.
- W4313365561 creator A5015763322 @default.
- W4313365561 creator A5015890840 @default.
- W4313365561 creator A5022888605 @default.
- W4313365561 creator A5029291174 @default.
- W4313365561 creator A5032497724 @default.
- W4313365561 creator A5033111679 @default.
- W4313365561 creator A5033291694 @default.
- W4313365561 creator A5033583336 @default.
- W4313365561 creator A5034180171 @default.
- W4313365561 creator A5036782575 @default.
- W4313365561 creator A5038538003 @default.
- W4313365561 creator A5040054190 @default.
- W4313365561 creator A5043098809 @default.
- W4313365561 creator A5047549223 @default.
- W4313365561 creator A5048338059 @default.
- W4313365561 creator A5049598090 @default.
- W4313365561 creator A5056307599 @default.
- W4313365561 creator A5062713815 @default.
- W4313365561 creator A5064119336 @default.
- W4313365561 creator A5072710799 @default.
- W4313365561 creator A5077822614 @default.
- W4313365561 creator A5081452566 @default.
- W4313365561 date "2022-12-29" @default.
- W4313365561 modified "2023-09-26" @default.
- W4313365561 title "Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle" @default.
- W4313365561 cites W1974047233 @default.
- W4313365561 cites W1981369237 @default.
- W4313365561 cites W1981831271 @default.
- W4313365561 cites W1992009195 @default.
- W4313365561 cites W2002973721 @default.
- W4313365561 cites W2080922260 @default.
- W4313365561 cites W2101870168 @default.
- W4313365561 cites W2105216281 @default.
- W4313365561 cites W2109481604 @default.
- W4313365561 cites W2114538920 @default.
- W4313365561 cites W2118409616 @default.
- W4313365561 cites W2119031910 @default.
- W4313365561 cites W2123106337 @default.
- W4313365561 cites W2126104386 @default.
- W4313365561 cites W2131380175 @default.
- W4313365561 cites W2138045549 @default.
- W4313365561 cites W2147694299 @default.
- W4313365561 cites W2156665896 @default.
- W4313365561 cites W2168498537 @default.
- W4313365561 cites W2169353806 @default.
- W4313365561 cites W2179510683 @default.
- W4313365561 cites W2261451134 @default.
- W4313365561 cites W2429359053 @default.
- W4313365561 cites W2537310520 @default.
- W4313365561 cites W2580897959 @default.
- W4313365561 cites W2600954565 @default.
- W4313365561 cites W2736848882 @default.
- W4313365561 cites W2767706598 @default.
- W4313365561 cites W2791038745 @default.
- W4313365561 cites W2793294336 @default.
- W4313365561 cites W2889713233 @default.
- W4313365561 cites W2891513200 @default.
- W4313365561 cites W2917601557 @default.
- W4313365561 cites W2920732619 @default.
- W4313365561 cites W2922562273 @default.
- W4313365561 cites W2942937020 @default.
- W4313365561 cites W2954879979 @default.
- W4313365561 cites W2969410982 @default.
- W4313365561 cites W2990428470 @default.
- W4313365561 cites W2999612022 @default.
- W4313365561 cites W3002380642 @default.
- W4313365561 cites W3007728540 @default.
- W4313365561 cites W3022131036 @default.
- W4313365561 cites W3037738062 @default.
- W4313365561 cites W3163231593 @default.
- W4313365561 cites W3168414855 @default.
- W4313365561 cites W3172639291 @default.
- W4313365561 cites W3174001059 @default.
- W4313365561 cites W3175752499 @default.
- W4313365561 cites W3195544197 @default.
- W4313365561 cites W3207121990 @default.
- W4313365561 cites W3217223379 @default.
- W4313365561 cites W4200519882 @default.
- W4313365561 cites W4200558012 @default.
- W4313365561 cites W4205380741 @default.
- W4313365561 cites W4211144975 @default.
- W4313365561 cites W4214901837 @default.
- W4313365561 cites W4221136004 @default.
- W4313365561 cites W4283780976 @default.
- W4313365561 cites W4297521033 @default.
- W4313365561 cites W4303649157 @default.
- W4313365561 cites W4313531093 @default.
- W4313365561 doi "https://doi.org/10.1101/2022.12.27.522062" @default.
- W4313365561 hasPublicationYear "2022" @default.
- W4313365561 type Work @default.
- W4313365561 citedByCount "0" @default.
- W4313365561 crossrefType "posted-content" @default.
- W4313365561 hasAuthorship W4313365561A5000866302 @default.
- W4313365561 hasAuthorship W4313365561A5004379567 @default.