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- W4313365571 abstract "SUMMARY A wealth of specialized cell populations within the skin facilitates its hair producing, protective, sensory and thermoregulatory functions, but how the vast cell-type diversity and tissue architecture develops is largely unexplored. Here, with single-cell transcriptomics, spatial cell-type assignment and cell-lineage tracing we deconstruct early embryonic mouse skin during the key transitions from seemingly uniform developmental precursor states to a multilayered, multilineage epithelium and complex dermal identity. We reveal the spatiotemporal emergence of hair-follicle-inducing, muscle-supportive, and fascia-forming fibroblasts. We also uncover the formation of the panniculus carnosus muscle, sprouting blood vessels without pericyte coverage, and the earliest residence of mast and dendritic immune cells in skin. Finally, we reveal an unexpected epithelial heterogeneity within the early single-layered epidermis and a signaling-rich periderm layer. Overall, this cellular blueprint of early skin development establishes histological landmarks – essential for placing cells in their spatial tissue context – and highlights unprecedented dynamical interactions among skin cells." @default.
- W4313365571 created "2023-01-06" @default.
- W4313365571 creator A5000071140 @default.
- W4313365571 creator A5002897632 @default.
- W4313365571 creator A5004024009 @default.
- W4313365571 creator A5016570232 @default.
- W4313365571 creator A5041203841 @default.
- W4313365571 creator A5044489751 @default.
- W4313365571 creator A5046648782 @default.
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- W4313365571 creator A5066006634 @default.
- W4313365571 creator A5070372040 @default.
- W4313365571 creator A5070888271 @default.
- W4313365571 creator A5088756285 @default.
- W4313365571 date "2022-12-29" @default.
- W4313365571 modified "2023-10-07" @default.
- W4313365571 title "Molecular and spatial design of early skin development" @default.
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