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- W4313365611 abstract "Abstract Antibodies show excellent stability in blood; therefore, they can be utilized for screening of convenient blood-based markers of Alzheimer’s disease dementia (AD). This study used unbiased microarrays comprising 29,240 random peptides to screen for AD-specific antibodies. The results showed that 1) antibodies are specifically regulated in AD and certain combinations show high area under the receiver operating characteristic curve values (0.862–0.961); 2) AD-specific IgG antibodies arise from established IgM antibody-secreting cells; and 3) analysis of proteins targeted by differentially regulated antibodies identified AD-related signaling pathways. Thus, plasma antibodies targeting specific epitopes are regulated in AD; these epitopes may facilitate biomarker development." @default.
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- W4313365611 date "2019-05-01" @default.
- W4313365611 modified "2023-10-01" @default.
- W4313365611 title "Epitope profiling of plasma antibody in Alzheimer’s disease dementia patients" @default.
- W4313365611 doi "https://doi.org/10.4049/jimmunol.202.supp.182.85" @default.
- W4313365611 hasPublicationYear "2019" @default.
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