Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313365612> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4313365612 endingPage "197.14" @default.
- W4313365612 startingPage "197.14" @default.
- W4313365612 abstract "Abstract There is no cure for HIV, largely because HIV establishes a small but sustained pool of latently infected cells that are not cleared by antiretroviral therapy (ART). Current strategies include firstly reactivating the latent HIV reservoir and then using T cell immunotherapy to clear reactivated cells. However, pre-ART CD8 T cell escape variants have been reported in the HIV reservoir, which may limit CD8 T cell recognition and clearance of HIV-infected cells. The extent of virus escape from T cells in the latent reservoir is unclear. HIV-specific T cell responses were comprehensively mapped across the Clade B HIV proteome by IFN-g ELISpot in 25 ART-suppressed participants. In parallel, replication competent viruses derived from supernatants of autologous resting CD4 T cells following mitogenic reactivation were sequenced. Peptides spanning virus variants within reactive T cell epitopes were synthesized and examined by ELISpot for evidence of escape, defined as ≥50% difference in T cell magnitude between peptide variants. No correlations were observed between the size of the latent HIV reservoir and either HIV-specific T cell breadth (1–19 epitopes) or magnitude (156–2855 SFU/M PBMCs). T cell escape was assessed in 17 participants. 39% of reactive T cell epitopes (48/124) harbored ≥1 amino acid variants in the sequenced latent reservoir. Of those 48, 20 afforded T cell escape, providing an overall escape frequency in the reservoir of 16% (20/124). These data show that the majority of replication competent latent HIV viruses do not harbor CD8 T cell escape mutants, suggesting that immunotherapy approaches that boost CD8 T cell responses can successfully target the latent reservoir in HIV curative and or remission strategies." @default.
- W4313365612 created "2023-01-06" @default.
- W4313365612 creator A5000425078 @default.
- W4313365612 creator A5007433649 @default.
- W4313365612 creator A5007488660 @default.
- W4313365612 creator A5008716404 @default.
- W4313365612 creator A5009684011 @default.
- W4313365612 creator A5016464841 @default.
- W4313365612 creator A5033471393 @default.
- W4313365612 creator A5038417176 @default.
- W4313365612 creator A5055421474 @default.
- W4313365612 creator A5057326864 @default.
- W4313365612 creator A5067715206 @default.
- W4313365612 creator A5073659364 @default.
- W4313365612 creator A5081889727 @default.
- W4313365612 creator A5082315352 @default.
- W4313365612 date "2019-05-01" @default.
- W4313365612 modified "2023-09-26" @default.
- W4313365612 title "Quantifying Virus Escape from T Cells in the Latent HIV Reservoir" @default.
- W4313365612 doi "https://doi.org/10.4049/jimmunol.202.supp.197.14" @default.
- W4313365612 hasPublicationYear "2019" @default.
- W4313365612 type Work @default.
- W4313365612 citedByCount "0" @default.
- W4313365612 crossrefType "journal-article" @default.
- W4313365612 hasAuthorship W4313365612A5000425078 @default.
- W4313365612 hasAuthorship W4313365612A5007433649 @default.
- W4313365612 hasAuthorship W4313365612A5007488660 @default.
- W4313365612 hasAuthorship W4313365612A5008716404 @default.
- W4313365612 hasAuthorship W4313365612A5009684011 @default.
- W4313365612 hasAuthorship W4313365612A5016464841 @default.
- W4313365612 hasAuthorship W4313365612A5033471393 @default.
- W4313365612 hasAuthorship W4313365612A5038417176 @default.
- W4313365612 hasAuthorship W4313365612A5055421474 @default.
- W4313365612 hasAuthorship W4313365612A5057326864 @default.
- W4313365612 hasAuthorship W4313365612A5067715206 @default.
- W4313365612 hasAuthorship W4313365612A5073659364 @default.
- W4313365612 hasAuthorship W4313365612A5081889727 @default.
- W4313365612 hasAuthorship W4313365612A5082315352 @default.
- W4313365612 hasConcept C140704245 @default.
- W4313365612 hasConcept C1491633281 @default.
- W4313365612 hasConcept C154317977 @default.
- W4313365612 hasConcept C159047783 @default.
- W4313365612 hasConcept C159654299 @default.
- W4313365612 hasConcept C167672396 @default.
- W4313365612 hasConcept C195616568 @default.
- W4313365612 hasConcept C202751555 @default.
- W4313365612 hasConcept C203014093 @default.
- W4313365612 hasConcept C2522874641 @default.
- W4313365612 hasConcept C2776090121 @default.
- W4313365612 hasConcept C2778190748 @default.
- W4313365612 hasConcept C2778852064 @default.
- W4313365612 hasConcept C2779053233 @default.
- W4313365612 hasConcept C2780195530 @default.
- W4313365612 hasConcept C2780727368 @default.
- W4313365612 hasConcept C2910359755 @default.
- W4313365612 hasConcept C3013748606 @default.
- W4313365612 hasConcept C54355233 @default.
- W4313365612 hasConcept C86803240 @default.
- W4313365612 hasConcept C8891405 @default.
- W4313365612 hasConceptScore W4313365612C140704245 @default.
- W4313365612 hasConceptScore W4313365612C1491633281 @default.
- W4313365612 hasConceptScore W4313365612C154317977 @default.
- W4313365612 hasConceptScore W4313365612C159047783 @default.
- W4313365612 hasConceptScore W4313365612C159654299 @default.
- W4313365612 hasConceptScore W4313365612C167672396 @default.
- W4313365612 hasConceptScore W4313365612C195616568 @default.
- W4313365612 hasConceptScore W4313365612C202751555 @default.
- W4313365612 hasConceptScore W4313365612C203014093 @default.
- W4313365612 hasConceptScore W4313365612C2522874641 @default.
- W4313365612 hasConceptScore W4313365612C2776090121 @default.
- W4313365612 hasConceptScore W4313365612C2778190748 @default.
- W4313365612 hasConceptScore W4313365612C2778852064 @default.
- W4313365612 hasConceptScore W4313365612C2779053233 @default.
- W4313365612 hasConceptScore W4313365612C2780195530 @default.
- W4313365612 hasConceptScore W4313365612C2780727368 @default.
- W4313365612 hasConceptScore W4313365612C2910359755 @default.
- W4313365612 hasConceptScore W4313365612C3013748606 @default.
- W4313365612 hasConceptScore W4313365612C54355233 @default.
- W4313365612 hasConceptScore W4313365612C86803240 @default.
- W4313365612 hasConceptScore W4313365612C8891405 @default.
- W4313365612 hasIssue "1_Supplement" @default.
- W4313365612 hasLocation W43133656121 @default.
- W4313365612 hasOpenAccess W4313365612 @default.
- W4313365612 hasPrimaryLocation W43133656121 @default.
- W4313365612 hasRelatedWork W1969781263 @default.
- W4313365612 hasRelatedWork W1986429144 @default.
- W4313365612 hasRelatedWork W2001342405 @default.
- W4313365612 hasRelatedWork W2052483994 @default.
- W4313365612 hasRelatedWork W2083087192 @default.
- W4313365612 hasRelatedWork W2155999541 @default.
- W4313365612 hasRelatedWork W3213677581 @default.
- W4313365612 hasRelatedWork W4220901781 @default.
- W4313365612 hasRelatedWork W4313359973 @default.
- W4313365612 hasRelatedWork W4313365612 @default.
- W4313365612 hasVolume "202" @default.
- W4313365612 isParatext "false" @default.
- W4313365612 isRetracted "false" @default.
- W4313365612 workType "article" @default.