Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313365651> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W4313365651 endingPage "186.10" @default.
- W4313365651 startingPage "186.10" @default.
- W4313365651 abstract "Abstract CD40 ligand (CD40L) is a well-known regulator of the adaptive immune response that induces and modulates the activation and differentiation of monocytes, dendritic cells, and lymphocytes. Less appreciated is its critical role in promoting the inflammatory response in CD40-expressing cells such as vascular endothelium. Expression of CD40L on TCR activated human CD4+ T cells is biphasic and upregulated by monocyte cell contact early and IL-2R signaling late. Here we demonstrate the existence of additional, distinct pathways that differentially regulate the expression of CD40L. We describe a novel link between vascular endothelial cell adhesion molecule 1 (VCAM-1), extracellular matrix (ECM) proteins, and CD40L expression on human CD4+T cells that constitutes an innate form of T cell costimulation modulated by the type and quantity of ECM protein present, with thrombospondin-1 inhibiting fibronectin-mediated costimulation of CD40L expression. Identification of this previously unrecognized β1 integrin pathway, which promotes CD40L expression on CD4+ T cells independently of monocytes and IL-2, provides new insights into our understanding of the potential role of CD40L in the establishment and progression of inflammatory disease." @default.
- W4313365651 created "2023-01-06" @default.
- W4313365651 creator A5000317216 @default.
- W4313365651 creator A5001821111 @default.
- W4313365651 creator A5006240342 @default.
- W4313365651 creator A5023900750 @default.
- W4313365651 creator A5041973530 @default.
- W4313365651 creator A5052866855 @default.
- W4313365651 creator A5056389032 @default.
- W4313365651 creator A5059169685 @default.
- W4313365651 creator A5067047470 @default.
- W4313365651 creator A5074035033 @default.
- W4313365651 creator A5086237607 @default.
- W4313365651 date "2019-05-01" @default.
- W4313365651 modified "2023-10-09" @default.
- W4313365651 title "Fibronectin Costimulation of CD40L Expression Integrates Innate and Adaptive Inflammatory Signals" @default.
- W4313365651 doi "https://doi.org/10.4049/jimmunol.202.supp.186.10" @default.
- W4313365651 hasPublicationYear "2019" @default.
- W4313365651 type Work @default.
- W4313365651 citedByCount "0" @default.
- W4313365651 crossrefType "journal-article" @default.
- W4313365651 hasAuthorship W4313365651A5000317216 @default.
- W4313365651 hasAuthorship W4313365651A5001821111 @default.
- W4313365651 hasAuthorship W4313365651A5006240342 @default.
- W4313365651 hasAuthorship W4313365651A5023900750 @default.
- W4313365651 hasAuthorship W4313365651A5041973530 @default.
- W4313365651 hasAuthorship W4313365651A5052866855 @default.
- W4313365651 hasAuthorship W4313365651A5056389032 @default.
- W4313365651 hasAuthorship W4313365651A5059169685 @default.
- W4313365651 hasAuthorship W4313365651A5067047470 @default.
- W4313365651 hasAuthorship W4313365651A5074035033 @default.
- W4313365651 hasAuthorship W4313365651A5086237607 @default.
- W4313365651 hasConcept C136449434 @default.
- W4313365651 hasConcept C1491633281 @default.
- W4313365651 hasConcept C154317977 @default.
- W4313365651 hasConcept C189165786 @default.
- W4313365651 hasConcept C193419808 @default.
- W4313365651 hasConcept C195687474 @default.
- W4313365651 hasConcept C202751555 @default.
- W4313365651 hasConcept C203014093 @default.
- W4313365651 hasConcept C2776090121 @default.
- W4313365651 hasConcept C2781184567 @default.
- W4313365651 hasConcept C39347974 @default.
- W4313365651 hasConcept C54355233 @default.
- W4313365651 hasConcept C55493867 @default.
- W4313365651 hasConcept C86492073 @default.
- W4313365651 hasConcept C86803240 @default.
- W4313365651 hasConcept C8891405 @default.
- W4313365651 hasConcept C95444343 @default.
- W4313365651 hasConceptScore W4313365651C136449434 @default.
- W4313365651 hasConceptScore W4313365651C1491633281 @default.
- W4313365651 hasConceptScore W4313365651C154317977 @default.
- W4313365651 hasConceptScore W4313365651C189165786 @default.
- W4313365651 hasConceptScore W4313365651C193419808 @default.
- W4313365651 hasConceptScore W4313365651C195687474 @default.
- W4313365651 hasConceptScore W4313365651C202751555 @default.
- W4313365651 hasConceptScore W4313365651C203014093 @default.
- W4313365651 hasConceptScore W4313365651C2776090121 @default.
- W4313365651 hasConceptScore W4313365651C2781184567 @default.
- W4313365651 hasConceptScore W4313365651C39347974 @default.
- W4313365651 hasConceptScore W4313365651C54355233 @default.
- W4313365651 hasConceptScore W4313365651C55493867 @default.
- W4313365651 hasConceptScore W4313365651C86492073 @default.
- W4313365651 hasConceptScore W4313365651C86803240 @default.
- W4313365651 hasConceptScore W4313365651C8891405 @default.
- W4313365651 hasConceptScore W4313365651C95444343 @default.
- W4313365651 hasIssue "1_Supplement" @default.
- W4313365651 hasLocation W43133656511 @default.
- W4313365651 hasOpenAccess W4313365651 @default.
- W4313365651 hasPrimaryLocation W43133656511 @default.
- W4313365651 hasRelatedWork W1839291999 @default.
- W4313365651 hasRelatedWork W1966498333 @default.
- W4313365651 hasRelatedWork W1995698795 @default.
- W4313365651 hasRelatedWork W2046507356 @default.
- W4313365651 hasRelatedWork W2103515427 @default.
- W4313365651 hasRelatedWork W2115780596 @default.
- W4313365651 hasRelatedWork W2330163142 @default.
- W4313365651 hasRelatedWork W2395488169 @default.
- W4313365651 hasRelatedWork W2414312069 @default.
- W4313365651 hasRelatedWork W3048316964 @default.
- W4313365651 hasVolume "202" @default.
- W4313365651 isParatext "false" @default.
- W4313365651 isRetracted "false" @default.
- W4313365651 workType "article" @default.